Volume 12 - March 2025

Exciting News: the ISDE 2025 Program at a Glance is Now Available!

We are thrilled to announce that the ISDE 2025 Program at a Glance is now live! Plan your attendance at the upcoming Congress - visit our website at 2025 Program at a glance - ISDE World Congress.

Register here to secure your spot at discounted rates - early bird registration ends on June 12, 2025!

Be part of this world-class event, filled with cutting-edge sessions and engaging discussions and book your accommodation in advance by visiting the ISDE 2025 Accommodation Options webpage.

Ahead of travelling to Brisbane, Australia, we recommend that you check the ISDE 2025 Visa Requirements webpage to learn more information and apply for the Australian Visa 2-3 months in advance.

We’re also excited to announce our partnership with Qantas! Enjoy exclusive discounts on selected flights to Brisbane. For more information, please visit the Congress website.

Discover more about Brisbane here!

See you in September!

Diseases of the Esophagus Special Collection on Eosinophilic Esophagitis

The Diseases of the Esophagus (DOTE) Journal is delighted to present this Special Collection on Eosinophilic Esophagitis with Evan Dellon serving as the Guest Editor. 

Over the past few decades, we have seen a rapid rise in understanding of this disease. This special collection showcases knowledge gained from the spectrum of EoE with studies on epidemiology, biomarkers, clinical presentations, treatments, and gaps to be addressed. By highlighting the latest discoveries and clinical perspectives, it aims to serve as a crucial resource for clinicians, researchers, and patients, enhancing the comprehension of this intricate and progressing condition. 

Read the EoE Collection 

DOTE - Volume 38, Issue 2, March 2025

The latest issue of Diseases of the Esophagus Journal is now available online.

Table of Contents:

Systematic Review and Meta-Analysis

• Treatment of intrathoracic anastomotic leakage following esophagectomy for gastroesophageal cancer: a systematic review

Original Articles

• Causes of death in locally advanced esophageal cancer undergoing neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy: a retrospective cohort study 

• Associations between body mass index and gastroesophageal cancer incidence and mortality: novel insights from a nationwide registry-based cohort study Open Access

• Robotic- assisted minimally invasive Ivor-Lewis handsewn anastomosis technique and outcomes from a large-volume European centre Open Access

Letter to the Editor

• Reliability of symptoms for diagnosis and sling fiber preservation for prevention of GERD after POEM: is there a problem?

• Letter to the editor: surgical treatment of esophago-tracheobronchial fistulas after esophagectomy

Editorial

• Tribute to Ikuo

Subscribe to Email Alerts

Members and Subscribers Article

Effect of benralizumab on histopathology and inflammatory signatures in a clinical cohort of eosinophilic esophagitis

The preliminary findings of this recent phase 3 trial of benralizumab, a monoclonal antibody that binds to interleukin-5 receptor alpha (IL5Rα), in patients with eosinophilic esophagitis (EoE) showed that while benralizumab significantly reduced tissue eosinophilia and improved endoscopic and histologic disease scores, it only provided partial symptom improvement. Despite successful eosinophil eradication, histologic analysis revealed persistent epithelial features of disease including basal cell hyperplasia and dilated intercellular spaces. Gene expression profiling confirmed that benralizumab-treated patients maintained transcriptional signatures similar to active EoE, with upregulation of inflammatory markers and downregulation of epithelial barrier genes. The researchers concluded that interleukin-5 receptor alpha blockade alone is insufficient to control EoE, as it fails to resolve the underlying epithelial dysfunction and inflammation despite eliminating eosinophils.

Fig. 1 Benralizumab significantly improves eosinophilic and endoscopic response in patients with baseline active eosinophilic esophagitis (EoE). Paired before benralizumab (pre-Benra) and following benralizumab treatment (post-Benra) patient samples. (A) Peak esophageal eosinophil counts displayed in eosinophils per high power field (eos/HPF) (n=10). (B) peripheral blood eosinophil counts (k/μL) (n=10). (C) endoscopic reference scoring (EREFS) shown as a sum of each clinical endoscopy findings score (n=11). Wilcoxon matched-pairs signed rank test, mean + SEM; *** p<0.001, ** p<0.01, *p<0.05.

See full article here

ISDE Welcomes Professor Jie He to the Board of Directors 

The International Society for Diseases of the Esophagus (ISDE) is pleased to welcome Professor Jie He to the Board of Directors.

A leading expert in thoracic oncology, Professor He is President of the Cancer Hospital at the Chinese Academy of Medical Sciences and Director of the National Cancer Center of China.

Learn more here

Apply for the Fanny Selena Prize 2025

The Fanny-Selena Prize, awarded by the French Association for Esophageal Atresia (AFAO), supports research on esophageal diseases. Named in memory of Fanny and Selena, two young girls who lost their lives to Esophageal Atresia, the prize funds innovative studies to improve patient care and treatment options.

Applications for the 2025 prize are now open. To learn more and apply, visit afao.asso.fr

Application Deadline: May 21, 2025

Literature Updates

A High-Resolution Microendoscope Improves Esophageal Cancer Screening and Surveillance: Implications for Underserved Global Settings Based on an International Randomized Controlled Trial

Minimally invasive versus open esophagectomy: Comparing the combined effects of smoking burden and operative approach on outcomes in esophagectomy

Esophagectomy Trends and Postoperative Outcomes at Private Equity–Acquired Health Centers

Anterior Gastropexy for Paraesophageal Hernia Repair A Randomized Clinical Trial

Outcomes of Salvage Surgery for Esophageal Carcinoma: A Nationwide Cohort Study from the Dutch Upper GI Cancer Audit

Real-World Effectiveness and Use of Dupilumab in Eosinophilic Esophagitis

Inpatient Gastroenterology Consults Have Little Utility Before Transesophageal Echocardiograms in a Prospective Cohort Study

Glucagon-Like Peptide Receptor Agonists Use Before Endoscopy Is Associated With Low Retained Gastric Contents: A Multicenter Cross-Sectional Analysis

Nonendoscopic Screening for Barrett's Esophagus and Esophageal Adenocarcinoma in At-Risk Veterans

The gut–brain axis and pain signalling mechanisms in the gastrointestinal tract

Differing Epithelial and Immunologic Activation Patterns Following Food Reintroduction Reveal Different Transcriptional Profiles in Active Eosinophilic Esophagitis

Definition and Predictors of Early Recurrence in Neoadjuvantly Treated Esophageal and Gastroesophageal Adenocarcinoma: a Dual-Center Retrospective Cohort Study

American Society for Gastrointestinal Endoscopy guideline on the diagnosis and management of GERD: summary and recommendations

Quality Indicators for Upper GI Endoscopy

Visit the ISDE Literature Updates Online for more.

INoEA 2025 - April 30 - May 3, 2024 in Instanbul

ESDE 2025 Congress - May 11 - May 13, 2025, in Amsterdam

21st ISDE World Congress - September 18-20 in Brisbane, Australia

Additional events of interest to the ISDE members and community can be found on the ISDE Events Calendar.