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Silke Nuber, Ph.D.
Associate Professor of Neurology, Harvard Medical School
Scientist, Ann Romney Center for Neurology Diseases, Brigham and Women’s Hospital
Silke Nuber, Ph.D. is a Scientist in the Ann Romney Center for Neurologic Diseases at Brigham & Women's Hospital (BWH) and an Associate Professor of Neurology at Harvard Medical School in Boston, MA USA. Her research focuses on understanding a-synuclein biology in the context of Parkinson’s disease (PD)-causing mutations, the contribution of endocrine, lipidic and environmental factors and development of therapeutics to prevent and treat synucleinopathies. Dr. Nuber earned a bachelor's and master (‘diploma) degree in biology and education from the University of Rostock and pursued her doctorate creating novel inducible mouse and rat models for PD from the University Hospital Tuebingen, Germany, that she further analyzed with her group with focus on a-synuclein protein interaction (calpain1, and synphilin). Moving to the USA in 2011, Dr. Nuber examined PD-related changes in post-mortem brains of dementia with Lewy bodies and in familial and sporadic PD, in comparison to neurotoxin-triggered and mutant mouse and rat models in the Masliah Laboratory at UC San Diego. Joining the Selkoe Laboratory at BWH, she generated entirely novel biochemically and phenotypically advanced mouse models that are based on a-synuclein tetramer abrogation and develop a striking PD-type tremor and limb deficits. Starting her lab at the ARCND 4 years ago, her lab was one of the first to investigate the impact of brain-selective estrogen and estrogen receptors in a-synuclein biology in vivo and in lipid saturation for the prevention and treatment of PD-phenotype progression in mice. Her current research involves: 1. Creating advanced preclinical models based on a-synuclein pathobiology found in Parkinson’s disease and in DLB brain; 2. The role of lipid saturation in distinct PD-causing mutations, including mutant GBA1-based Gaucher’s and PD; and 3. The effects of brain-selective sex hormones and estrogen receptor distribution on a-synuclein biology and synaptic function. Her lab is funded by NIH, the Michael J Fox Foundation for Parkinson’s disease Research, the Women’s Brain Initiative, the Silverstein Foundation and the Orchard Foundation. Dr. Nuber serves as an advisor to the Michael J Fox Foundation, in addition she serves as a consultant for companies.
Join in person in the Marshall Wolf Conference Center, Hale BTM, 3rd floor or via Zoom https://partners.zoom.us/j/5823462701
*Lunch will be served for in-person attendees
Steps to claim CME credits for BWH Neurology Grand Rounds:
Send code JUVBAM to 1-857-214-2277.
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