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Peripherin is a type III intermediate filament protein predominantly expressed in the peripheral nervous system (PNS) and, to a lesser extent, in particular central nervous system (CNS) neurons with projections toward peripheral structures. It is vital in neurite elongation during development and axonal regeneration following injury. Peripherin's involvement in neuronal differentiation, growth, and regeneration makes it an essential target for neuroscience research.
Interestingly, altered peripherin expression has been linked to various neurological disorders, such as amyotrophic lateral sclerosis (ALS), Parkinson's disease, and diabetic neuropathy. Furthermore, peripherin is emerging as a distinctive biomarker for axonal damage. Elevated serum peripherin levels have been observed in peripheral nervous system diseases like Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Investigating peripherin's role in these conditions could provide valuable insights into disease mechanisms and potential biomarkers or therapeutic targets.
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