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The RNA Transcript | October 9, 2023

Breaking News

2024 RNA Symposium Speaker Awarded Nobel Prize

On October 2, the Nobel Prize Committee awarded the 2023 Nobel Prize in Physiology or Medicine jointly to Katalin Karikó and Drew Weissman.


Drew Weissman, M.D., Ph.D., will be featured as a keynote speaker at the Center for RNA Biomedicine's 8th annual RNA Symposium in March, 2024 at the University of Michigan. He currently serves as Director of the Penn Institute for RNA Innovation, and is a leading physician and researcher at Penn Medicine. Read more.

This Week: Guizhi (Julian) Zhu, Ph.D.

Guizhi (Julian) Zhu, Ph.D., will present on a topic involving RNA vaccines that has close ties with that of recent The Nobel Prize winner Drew Weissman.


“Engineer and deliver nucleic acid immunotherapeutics and vaccines – a focus on small circular mRNA (circRNA) vaccines”


Guizhi (Julian) Zhu, Ph.D.

Ara G. Paul Associate Professor of Pharmaceutical Science

University of Michigan


Today - Monday, October 9, 2023

4:00 PM - 5:00 PM

BSRB ABC Seminar Rooms, Hybrid Link

Affiliated Seminars

“In vivo regeneration of neurons via reprogramming glial cells”


Presented by: Thanh Hoang, Ph.D.

Assistant Professor

Department of Cell & Developmental Biology University of Michigan

 

Today - Monday, October 9

12:00 PM – 1:00 PM EST | 5915 Buhl

 

Hosted by: Sally Camper, Ph.D. Faculty Member Center for RNA Biomedicine,

"The Role of Noncoding RNAs and RNA Binding Proteins in Cancer: Shedding Light on the Transcriptomic Dark Matter"


Speaker: Shannon Lauberth, Ph.D.

Associate Professor, Biochemistry and Molecular Genetics

Northwestern University


Tuesday October 10, 202312:00 pm

Medical Science Unit I - Room 5330

Helmholtz Institute for RNA-based Infection Research (HIRI)


Speaker Anuja Kibe, PhD, “The translational landscape of HIV-1 infected cells reveals novel gene regulatory principles”


Speaker Patrick Bohn, "Native long read RNA structure probing to reveal RNA interaction sites"


Speaker Sahil Sharma, PhD, “Endogenous RNA targeting by RNA-guided nuclease Cas9 in its native host”


Moderator: Neva Caliskan, PhD

Zoom Registration link: 


October 11, 2023, 10 AM ET Zoom Registration

Seminar: miRNAs and RNAi - From mechanisms to biology


October 12 | 2:00 PM TO 3:00 PM

Forum Hall, Palmer Commons

This is a public event.


Speaker: Eric Lai, Ph.D.

Member, Memorial Sloan Kettering Cancer Center


Host: Cheng-Yu Lee

“Systems Biology Tools for Drug Discovery and Metabolic Modeling”


Presented by:

Sriram Chandrasekaran, Ph.D.

Associate Professor

Biomedical Engineering

University of Michigan

 

Monday, October 16

11:00 AM – 12:00 PM EST

BSRB - 1020 Kahn Auditorium

 

Hosted by:

Sundeep Kalantry, Ph.D.

Professor Human Genetics

University of Michigan


Oral Defenses

U-M Oral Dissertations

Integrative Analyses of Genetic and Genomic Sequence Data to Improve Gwas Interpretation


Sarah Hanks, Biostatistics

Advisors: Michael Lee Boehnke and Laura Scott


Thursday, October 12, 2023

2:00 PM

PMSPH2 M4034 Zoom

On the Evolution of Sperm Morphology and Sperm-Related Genes in a Howler Monkey Hybrid System


Molly Hirst, Ecology & Evolutionary Biology

Advisors: Liliana Cortes-Ortiz and Trisha Wittkopp


Wednesday, 18 October 9AM

BIOLOGICAL SCIENCES BUILDING ROOM 1010

Kinesin Regulation via Kinesin Binding Protein (KIFBP) And Autoinhibition


Zhenyu Tan, Biophysics

Advisor: Michael Cianfrocco, Ph.D.


Wednesday, October 18

10:00 AM

RACKHAM GRADUATE SCHOOL, EARL LEWIS ROOM

For more information and to view the full schedule of upcoming U-M Oral Defenses, please visit the Rackham Graduate School Oral Defenses website.

RNA SOCIETY

News

The RNA Society has once again entered into an agreement with Lexogen for continued support of the RNA Salon program including the option to receive 2 years of RNA Salon funding.

 

With this agreement in place, we have now opened the application system and invite RNA Salon applications for 2023/24. High-quality applications will once again be chosen for two years of funding.

 

You will find details regarding the application guidelines and the link to the application system on the RNA Society website: https://www.rnasociety.org/salons

 

Applications will be accepted until October 20, 2023. If you cannot meet this timeline due to exceptional circumstances, or for more information, please contact Ute Kothe, RNA Salon Program Coordinator, at Ute.Kothe@umanitoba.ca

Lexogen RNA Expertise Blog Series

Our August 29, 2023 blog post: Paper talk with Michael Schon, Phd – Bridging gaps in transcript assembly

LEXOGEN RNA EXPERTISE blog series covers various topics from the world of RNA and RNA-Seq, focusing on best practices, exciting applications, and more. 

In the News

John Prensner charts a new path toward global standardization for ribosome profiling (Ribo-Seq)

Rooted firmly in his lab suite tucked deep within the core of the Pentagon-esque Medical Sciences Research Building (MSRB) complex on the University of Michigan campus, John Prensner, M.D., Ph.D., is focused on bringing to light an area of genomic investigation involving a hive of “worker bees” called noncanonical ORFs (open reading frames), that play a vital role in the regulation of RNA translation in the human genome.


Prensner’s work relies on a next-generation, deep-sequencing-based tool known as ribosome profiling (Ribo-Seq) which allows Prensner and his team to identify ORFs, which are the select portions of RNA molecules that give rise to proteins...

Read the full story

Meetings

New! UM Tissue Barriers iPSC Meeting at Kellogg Eye Center

Center for RNA Biomedicine Faculty Member Rajesh C. Rao, M.D. will be presenting a talk at the UM Tissue Barriers iPSC Meeting Tuesday, October 17.


"Stem Cell Therapy: Can We Repair the Barrier?"


October 17, 2023

Session 3 | 1:20-2:10

Kellogg Eye Center


Stem Cells: iPSC Modeling Meeting flyer.

10XGenomics Spatial World Tour: Ann Arbor | October 11

Join us for this exclusive showcase of our revolutionary spatial in situ product, Xenium designed to transform the way you characterize up to millions of cells with high-plex RNA profiling in native tissue environments. Experts from our R&D team, members of 10x senior leadership, and Xenium users will unveil the incredible potential and applications of this technology to power your research in ways you never imagined.


October 11, 2023

9:00 AM - 3:00 PM ET


University of Michigan North Campus Research Complex (NCRC), Dining Room

2800 Plymouth Rd, Building 18


Register at 10xgenomics.com

ICBS 2023 Annual Conference | Ann Arbor, October 8-11

The International Chemical Biology Society (ICBS) 2023 annual conference will be Ann Arbor, October 8-11, 2023.

 

This is a great opportunity for University of Michigan students and postdocs to attend an international meeting without the travel costs. There is also going to be a pre-meeting trainee session on Oct 8.


For more information, email 2023ICBS@gmail.com


Learn more about joining ICBS.

RNA Biology & Disease Symposium

Boston Children’s Hospital Stem Cell Program | October 17, 2023

Join us on Tuesday, October 17th for the RNA Biology & Disease Symposium sponsored by the Stem Cell Program at Boston’s Children’s Hospital and supported by the Harvard Initiative for RNA Medicine. Throughout the day, you’ll hear from experts within the field as you learn more about the latest research developments linking RNA pathways to disease and emerging therapeutics.

 

The full day event will be held in the Folkman Auditorium in the Enders building at the Boston Children’s Hospital.

 

See more details about the program and register here: RNA Biology & Disease Symposium

 

Please note, registration closes on October 6

 

Inquiries reach out to Julie Nolan-Young at Julie.Nolan-Young@childrens.harvard.edu

Nature Conferences

Cracking The Code: The Dawn of Nucleic Acids - October 17-19, 2023

Register Here

In-person Nature Conference at Worcester Polytechnic Institute, Worcester, MA.


The conference will discuss the development of nucleic acid medicines — both the recent clinical successes, and current and upcoming challenges. By bringing together academics in basic and translational research and their peers in thriving biotechnology companies and promising start-ups, the conference aims to foster dialog and to spearhead collaborations. 

Midwest Symposium for Oligonucleotide Therapeutics - November 12-13

Free Registration (virtual, in-person)

Eli Lilly is sponsoring a Midwest Symposium for Oligonucleotide Therapeutics (Nov 12-13) at the Hilton Indianapolis Hotel and Suites. Registration is free and it is a great opportunity for students (and PIs) to network, learn about RNA therapeutics from leading experts in the field, and share their work on RNA biology, oligonucleotide chemistry, RNA/DNA editing, and/or oligonucleotide delivery.

 

We have an exciting line up of keynote and invited speakers committed to present at the symposium. These include Stanley Crooke (Ionis, n-Lorem Foundation), Ron Weiss (MIT), Sudhir Agrawal (University of Massachusetts, ARNAY Sciences), Thomas Gaj (University of Illinois), and Craig Duvall (Vanderbilt University). Register at the link above.

16th Annual BIDMC Cancer Center Symposium - November 17, 2023

Targeted and Immune – Based Cancer Therapy

Register Here

On behalf of the Cancer Center at BIDMC, we invite you to join us for the 16th Annual BIDMC Cancer Center Symposium which will be held in-person at the Joseph B. Martin Conference Center.

 

The symposium will provide updates and presentations from some of the most renowned physicians in the field of cancer research and targeted immune based therapies.

Joint Keystone Symposia on RNA Modifications / Regulatory RNAs

Keystone Symposia Meetings:

RNA Modifications in Health and Disease and Regulatory RNAs: Emerging Mechanisms 


December 12-16, 2023 in Banff, AB, Canada


The deadline to submit your abstract for the joint has passed. Registration open. Register by October 12 to receive the discounted rate ($200 savings!). 


For more information and to register for meetings, visit: Keystone Symposia

Our members' publications are available through Altmetric. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation.


Below are recent highlights.

Roggenbuck J, Eubank BHF, Wright J, Harms MB, Kolb SJ; ALS Genetic Testing and Counseling Guidelines Expert Panel. Evidence-based consensus guidelines for ALS genetic testing and counseling. Ann Clin Transl Neurol. 2023 Sep 10. doi: 10.1002/acn3.51895. Epub ahead of print. PMID: 37691292. https://doi.org/10.1002/acn3.51895

Perelman RT, Schmidt A, Khan U, Walter NG. Spontaneous Confinement of mRNA Molecules at Biomolecular Condensate Boundaries. Cells. 2023 Sep 11;12(18):2250. doi: 10.3390/cells12182250. PMID: 37759470; PMCID: PMC10526803. https://doi.org/10.3390/cells12182250

Harrison KR, Snead D, Kilts A, Ammerman ML, Wigginton KR. The Protective Effect of Virus Capsids on RNA and DNA Virus Genomes in Wastewater. Environ Sci Technol. 2023 Sep 1. doi: 10.1021/acs.est.3c03814. Epub ahead of print. PMID: 37656816. DOI: https://doi.org/10.1021/acs.est.3c03814

Burdick JT, Comai A, Bruzel A, Sun G, Dedon PC, Cheung VG. Nanopore-based direct sequencing of RNA transcripts with ten different modified nucleotides reveals gaps in existing technology. G3 (Bethesda). 2023 Sep 1:jkad200. doi: 10.1093/g3journal/jkad200. Epub ahead of print. PMID: 37655917. https://doi.org/10.1093/g3journal/jkad200

Job Postings

Postdoctoral Fellow UMich Department of Pathology


The laboratory of Dr. Sethu Pitchiaya, Assistant Professor, Department of Urology, Department of Pathology at the University of Michigan seeks to hire an enthusiastic Postdoctoral fellow to work on exciting projects related to mammalian stress response mechanisms. Learn more.

University of Michigan BIBC Tenure Track Faculty Search


The University of Michigan has launched a Tenure Track Faculty Search for the BioInnovations in Brain Cancer Initiative (BIBC), led by Center for RNA Biomedicine Faculty Member Dr. Maria G. Castro and Dr. Steven Schwendeman. Learn more.

The University of Michigan Single Cell Spatial Analysis Program is hiring for Faculty Positions


Intellectual foundation and research resources to enhance single-cell and spatial analyses. Learn more.

RNA Biology Laboratory at the National Cancer Institute - Biologists



Part of NIH in Frederick, MD, is currently seeking to recruit outstanding RNA biologists. Learn more.

The University of California Irvine (UCI), Department of Ophthalmology

Full-Time Position


Inviting applicants focused on the development of genetic engineering and genome editing technologies. Learn more.

Postdoctoral Research Fellow and Graduate Research Assistants

Dr. Guizhi (Julian) Zhu Lab | University of Michigan


Multiple full-time openings for Postdoctoral Research Fellow and Graduate Research Assistants. Learn more.

Research Technician and Post-Doctoral Research Fellow | Fred Hutchinson Cancer Center | The Lapointe Lab


Seeking to fill two positions: Research Technician and Post-Doctoral Research Fellow. Learn more.

Research Technician - Yadavalli Lab



Seeking full-time technician or research scientist to perform cutting-edge research in RNA biology using high-throughput sequencing methods. Learn more.

Postdoctoral Position - Maquat Lab


A postdoctoral position is open. Applicants should hold a PhD or MD/PhD degree(s) and have expertise in molecular, cellular, or structural biology. Learn more.

Postdoctoral Position - Cooperman Laboratory


Seeking postdoctoral student with a strong interest in understanding the mechanism and regulation of cytoplasmic eukaryotic protein synthesis. Learn more.

Volunteer - RNA Society


Seeking to fill the position of RNA Salon Program Coordinator and invites current Full members interested in leading this program to come forward. Learn more.

For complete details on current openings and how to apply for these positions, visit the Recruitment Opportunities page on our website.

Recruitment Opportunities

2024 RNA Symposium

"Unmasking the Power of RNA: From Structure to Medicine."


The 8th annual symposium will take place on Friday, March 8, 8:30 a.m. - 4:00 p.m. in the A. Alfred Taubman Biomedical Science Research Bldg., Kahn Auditorium at 109 Zina Pitcher Place in Ann Arbor, Michigan.


Speakers: Drew Weissman, M.D., Ph.D., University of Pennsylvania; Victoria D'Souza, Ph.D., Harvard University; Brenton R. Graveley, Ph.D., University of Connecticut; Leemor Joshua-Tor, Ph.D., Cold Spring Harbor Laboratory; and Peter Todd, M.D., Ph.D., University of Michigan


Save the date!

To share your news and comments, please contact

rna-communications@umich.edu

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