Committed to Excellence in Cancer Research, Education and Patient Care
Inroads
May 2023
Prostate Cancer Biorepository:
Connecting Patients, Clinicians & Researchers in the Fight Against Cancer
Elisa Ledet, PhD, has helped direct the growth of Tulane Cancer Center's Prostate Cancer Biorepository since its launch in 2014.
"From bedside to lab bench and back, this biorepository represents the culmination of translational research, directly connecting patients, clinicians, and basic research scientists in the fight against cancer," said Elisa Ledet, PhD, research instructor and director of Tulane Cancer Center's Prostate Cancer Biorepository.

Primarily composed of approximately 9,000 blood and tissue samples from 854 prostate cancer patients seen at Tulane Medical Center, this biorepository was launched in 2014 by Dr. Oliver Sartor – previous head of Tulane Cancer Center's Prostate Cancer Research Program – in collaboration with fellow clinicians and basic science researchers across many disciplines at Tulane.

Dr. Sartor continues to collaborate with Dr. Ledet on the growth and development of the biorepository. And since its launch, the facility has evolved, becoming a unique and robust research resource for a number of prostate cancer clinicians and investigators not only at Tulane but at other institutions around the world. "These efforts have provided a breadth of experience and expertise which have resulted in a thriving translational prostate cancer research program here," said Ledet.

In addition to prostate cancer samples – which span the full spectrum of prostate cancer diagnoses, from early and indolent disease to advanced metastatic castration resistant prostate cancer – the facility also houses the clinical data associated with each sample collected, including patient demographics, family history, initial diagnosis and staging, histopathology, diagnostic imaging results, lab values, genetic testing results, and treatment history.

Recently, the facility expanded to include tissue samples and associated clinical data for other genitourinary malignancies as well, including renal and bladder cancer. And efforts are underway to incorporate gynecologic, neurologic and hematologic malignancies and lung cancer.

"The biorepository is actively engaged with a number of Tulane Cancer Center clinicians and basic research scientists to specifically address their research interests and provide the tissue specimens and associated clinical data needed for their investigations," said Ledet. "This active engagement fosters collaborative relationships, which makes truly translational research flourish and grow at Tulane Cancer Center."

In addition to biological samples, the biorepository has developed and maintained a robust clinical data repository for over 2,500 prostate cancer patients treated at Tulane Medical Center. Derived from clinicians in both the Department of Urology and the Tulane Cancer Center, detailed patient data has been collected and utilized for a myriad of clinical studies. Most importantly, as a component of clinical care, detailed cancer family history data has been recorded, in conjunction with an expansion of genetic testing in prostate cancer patients. This family history data is an invaluable resource for ongoing studies of hereditary prostate cancer.

While Southeastern Louisiana is dubiously known as “cancer alley” and Tulane’s catchment area encompasses racially diverse, medically underserved, and rural populations, there have been significant barriers to conducting translational research in these groups. The goal of Tulane Cancer Center's Biorepository is to overcome these barriers and forge partnerships between patients, clinicians and basic scientists by identifying opportunities for collaboration and serving as a foundational resource for unique and truly impactful translational research at Tulane.

Clinicians or basic research scientists interested in utilizing the translational research resources of Tulane Cancer Center's Prostate Cancer Biorepository can contact Dr. Ledet at eledet@tulane.edu.
Zhen Lin & William Wimley Awarded
Ladies Leukemia League Grants
Two Tulane Cancer Center researchers – Zhen Lin, MD, PhD, (bottom row far right) and William C. Wimley, PhD (bottom row far left) – were each recently awarded $35,000 Ladies Leukemia League (LLL) grants to help support their leukemia and lymphoma research projects.
 
Founded in 1969, LLL is a volunteer organization of 225 women dedicated to raising funds for leukemia and lymphoma research in Louisiana, Mississippi and Texas. Since their founding, they have raised over $4.5 million, which they have distributed as "seed" money to research scientists working in leukemia and lymphoma research or related fields.
 
The LLL issues a call for grant applications each fall and then utilizes a panel of medical advisors to evaluate proposals and make recommendations for funding. They cap awards at $35,000 per investigator in order to provide support for as many worthy projects as possible.
 
Tulane's current grant recipients were recognized and awarded with the first half of their grants at the organization's annual grant recipient luncheon, which took place in April. The balance of their awards will be distributed at the halfway point in the grant period, during the organization's annual Fête de Noël Luncheon.
 
This luncheon / fashion show is LLL’s major annual fundraiser and a premiere benefit of the Holiday Season in New Orleans. It is scheduled to take place on Tuesday, November 28, 2023 at the Hilton Riverside Hotel. For more information, please click here.

Learn more about the Tulane research projects selected to receive LLL funding this year below.

(Seated bottom middle in the photo above is M.D. Anderson researcher Rasoul Pourebrahimabad, MD, PhD)
Zhen Lin, MD, PhD
Associate Professor of Pathology
Technical Director of Molecular Pathology Laboratory

Development of a Novel Targeted Therapeutic Strategy for Epstein-Barr Virus (EBV)-Associated Lymphoma

Epstein-Barr virus is a human oncogenic virus related to a group of hematologic cancers known as EBV-associated lymphoma (EBVaL). Patients with EBVaL usually have co-morbidities and cannot well tolerate conventional intensive chemotherapy, leading to worse prognoses. There is an urgent need, therefore, to improve the current therapeutic regimen.

Sphingolipids are bioactive signaling molecules that regulate multiple cellular processes. Ceramide serves as a central hub in sphingolipid metabolism and plays key roles in the regulation of cellular reproduction. The Lin team hypothesizes, based on the literature and their preliminary findings, that EBVaL can be managed by precisely targeting the sphingolipid pathway.

The immediate objective of this application is to evaluate and validate the therapeutic benefits of using ceramide analogs to eliminate EBVaL in both cell and animal models. If successful, these studies will provide significant pre-clinical insight regarding this novel strategy in treating EVBaL.
William Wimley, PhD
George A. Adrouny Professor of Biochemistry and Molecular Biology

Delivery of Peptide and Protein Cargoes to Leukemia Cells

Cancer is a disease of abnormal signaling within intracellular protein interaction networks. Such networks are most readily inhibited by peptide and protein therapeutics, not by conventional drugs. However, peptide and protein therapeutics do not spontaneously enter the cell cytosol – the liquid found inside of the cells.

The Wimley lab has been evolving nanoparticle-forming peptides that can deliver peptide and protein cargoes into cells via endocytosis – the process through which a living cell takes in or absorbs matter.

In this project, Wimley's team will optimize this unique system for delivery of cancer killing pro-apoptotic peptides and proteins to cancer cells. This work will enable the inhibition and characterization of protein interaction networks in leukemia cell lines, can help guide clinical treatment decisions in patients and may offer a pathway to a novel class of therapeutics.
ACS & NFL Team Up to Develop
Online Cancer Risk Assessment Tool
The Defender is the American Cancer Society's free online cancer risk assessment tool that provides personalized tips to reduce your risk of cancer.
The American Cancer Society (ACS) is bringing awareness to the many types of cancer and the impact cancer has on lives, the economy and worldwide care. One goal is to boost cancer prevention by identifying modifiable risk factors such as smoking, alcohol use, poor diet and lack of exercise.

A tool created to help identify those risk factor is The Defender, a free, online cancer risk assessment tool developed by the ACS in partnership with the NFL. Participants answer a few questions, and in minutes, an action plan is provided with personalized MVP Tips — the ‘Most Valuable Prevention’ Tips.

Give The Defender a few minutes of your time and it will show you how to reduce your cancer risk. Start here.
The Answer to Cancer is Research....
AND the Cancer Crusaders
Accepting the Cancer Crusaders donation check are LSU's Augusto Ochoa, MD, (third from left) and Erik Flemington, PhD, Zimmerman Endowed Professor of Cancer Research at Tulane Cancer Center (second from right). Also pictured are 2023 co-presidents Kim Hasney (far left) and Jackie Hughes (far right) and 2022 president Kathy Pastorek (second from left).
At the May Board Meeting of the Cancer Crusaders, Kathy Pastorek, immediate past president, and Kim Hasney and Jackie Hughes, 2023 co-presidents, presented LSU's Augusto Ochoa, MD, and Erik Flemington, PhD, Zimmerman Endowed Professor of Cancer Research at Tulane Cancer Center, with a check for an incredible $214,871.72 – funds raised by the organization through their various fundraising events in 2022.

Cancer Crusaders – a non-profit, all volunteer organization with no administrative overhead – was founded in 1976 to raise funds for cancer research in the New Orleans area. The group has raised approximately $4.3 million since its incorporation in 1978, and these funds have been split equally between the cancer research programs at Tulane and LSU.

"The Cancer Crusaders' fierce advocacy, tireless commitment and financial support are deeply appreciated and nothing short of vital to our mission," said Prescott Deininger, PhD, director of Tulane Cancer Center. "Each dollar they raise and donate is pivotal to our cancer research progress as we continue to pursue a better understanding of the biology of cancer and how to make improvements in care. It is through research that our knowledge of how to detect and treat cancers will become better defined. Thanks to the support of Cancer Crusaders, our investigations will continue to evolve and advance as we travel the road – together – to new treatment options and cures."

For more information on Cancer Crusaders events – including their Celebration of Life Luncheon scheduled for September 15 – visit https://cancercrusadersla.com/.
You Had Me at Chocolate!
Unique Fundraiser Benefits Breast Cancer Research
Guests at Death by Chocolate...NOT Breast Cancer will enjoy 12 tasty bites both sweet and savory created by students in and alumni of Delgado Community College's Culinary and Pastry Arts Program and then vote for their favorite, all while raising important funds for breast cancer research.
Be a part of the fight against breast cancer while enjoying a feast for the senses. Join Krewe de Pink for their Fourth Annual Death by Chocolate…NOT Breast Cancer fundraiser, benefiting Tulane Cancer Center's Breast Cancer Research Fund.

The event takes place on

Saturday, June 17, 2023

Schoen Mansion
3827 Canal St., New Orleans

VIP Admission - 5:30 PM
General Admission - 6:30 PM

Krewe de Pink, in partnership with Delgado Community College’s Culinary and Pastry Arts Program and Jacob Schoen & Son, has created a chocolate and champagne tasting event like no other. Twelve tasty chocolate bites both sweet and savory will be created by the Delgado culinary and pastry arts students and alumni with chocolate donated by Callebaut Chocolate, home of the finest Belgian chocolate.

At this 21 and older event, guests will enjoy the scrumptious chocolate creations* with bubbly which has been graciously provided by Josh Wine Cellars. (Non-alcoholic beverages, including still and sparkling water and coffee, are also available.) Live music will be performed by the Delgado Jazz Combo, and there will be raffles for a champagne basket or a stunning diamond necklace donated by Diamonds Direct. A fabulous pink photo station will also be available for guests to capture every special moment. And as a thank you, attendees will receive a chocolate treat as a takeaway, compliments of Delgado Community College and Callebaut.

The event is a live competition. Each student will be judged by guests and local chefs on their chocolate-inspired dishes, with 1st- and 2nd-place honors awarded in both the Peoples' Choice and Judges Choice categories. Winners will receive scholarships and cash prizes.

Krewe de Pink will also honor eleven local breast cancer survivors whose battles will inform and inspire. This year's "Sweet Survivors" include:

Gina Pausina Cherry
Jonell Deshotel
Mary Franco
Camey Grau
Kristyn Kemp
Amelia Finley Leonardi
Holly McCollum
Ashley O’Bryan
Nancy Pesses
Amy Storms
Jo Ann Toomy

To learn more about their stories, please click here.

VIP ticket holders will enjoy exclusive early access to the event at 5:30 PM, allowing them time to mingle with the local celebrity chefs and the 2023 Sweet Survivors. VIP guests will also receive exclusive takeaways. General admission begins at 6:30 PM.

The event will be held at Schoen Mansion on world-famous Canal Street. This exquisite city landmark, which features unique architecture, fine furnishings, spectacular chandeliers, stunning mantels, and beautiful gardens, provides an elegant setting for this fun, exciting and deliciously decadent event.

The dress code is festive cocktail. Feel free to wear wigs, boas or whatever helps you feel festive! Wearing pink is a plus!

VIP tickets are $100 and are advanced sale only. General admission is $60 in advance and $75 at the door (provided the event is not sold out). To purchase yours, please click here.

Those who attend are in for a unique and memorable experience full of wonderful sights, scents, sounds and tastes, all while supporting breast cancer research at Tulane Cancer Center.

* For those with food allergies, each dish is designated with common allergens. A list of ingredients is available upon request.
Pink Bra Run Participants Brave the Weather to Raise Funds for Breast Cancer Research
Winners of the annual "Best Decorated Bra Contest" receive their prizes.
Rain didn't dampen the spirits of those who came decked out in their finest bedazzled bras for Krewe de Pink's (KDP) recent Pink Bra Run & Bike Ride, benefiting Tulane Cancer Center's Breast Cancer Research Program.

Walkers, runners, partiers, and – for the first time this year – bike riders gathered to complete their routes atop the Mississippi River levee, with the unmistakable New Orleans city skyline as a backdrop.

Storms may have cut the after-race party a little short, but not before participants got to enjoy tasty food, cold beverages, lively music, and the highly anticipated and entertaining "Best Decorated Bra" contest. Winner David Libiez – who also won the race – is pictured above (center).

"We came to New Orleans for a family birthday crawfish boil, and since I'm a runner, I looked for a race to participate in while we were here. I found the Pink Bra 5K online, and after seeing the Krewe de Pink website, I knew I had to go all in, bra and all," said Libiez. "Decorating the bra became a family project. I'm not sure which was more satisfying, winning the race or winning the bra contest! I'm just glad I was able to support Krewe de Pink's fundraising efforts and appreciate what they do."

Members of Krewe de Pink work tirelessly to plan unique, New Orleans-style fundraisers that are not only incredibly fun but incredibly important as well. "Funds raised through the Pink Bra Run and other KDP events are put to work in the laboratories of our breast cancer researchers, providing them with the flexibility of highly valued unrestricted resources for rapid pursuit of theories not necessarily supported by other funding," said Tulane Cancer Center Director Prescott Deininger, PhD. "This level of flexibility is vital to our research progress and only possible through the support of our friends in KDP. We can't thank them enough."

To learn more about Krewe de Pink's annual events, visit their website at www.KrewedePink.org.