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CCMBM Spring Update
The Core Center for Musculoskeletal Biology & Medicine (CCMBM) defines itself by emphasizing musculoskeletal-specific education and services that are critical to its members but not available elsewhere in the university system
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In individuals with type 2 diabetes (T2D), fracture risk is increased, in part due to intrinsic skeletal disease. Among the multifactorial etiologies of skeletal fragility in T2D, bone marrow adipose tissue (BMAT) is a metabolic fat depot that may also play a negative role in skeletal disease and specifically in T2D. Whether enhanced glycemic control affects skeletal outcomes through pathways such as BMAT is unknown.
Our group is currently investigating the effects of improved glycemic control on BMAT and skeletal outcomes in a longitudinal, prospective study of older Veterans with type 2 diabetes at the San Francisco VA. To date, 48 participants have enrolled and are actively working with their clinicians to improve the medical management of their diabetes.
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Figure 1: Greater bone marrow adipose tissue (BMAT) levels are seen in osteoporosis and other skeletal disorders. Mechanisms for the negative effects of BMAT on bone include: enhanced adipogenesis at the expense of osteoblastogenesis, a direct negative effect of adipocytes on osteoblasts, and adipocyte promotion of osteoclastogenesis. |
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May 10, 12:30-2:00pm PT / 3:30-5:00pm ET; Virtual Event
This seminar series focuses on musculoskeletal research from our Early Stage and Junior Investigators as an opportunity to share their research across UCSF and Harvard institutions through the CCMBM and CSR.
The May 2024 featured speakers are:
Muriel Babey, MD, Assistant Professor of Medicine, Division of Endocrinology and Metabolism, UC San Francisco
“Brain-Derived CCN3 is An Osteoanabolic Hormone that Sustains Bone in Lactating Females”
Nora Renthal, MD, PhD, Instructor of Pediatrics at Harvard Medical School and Medical Director of the Bone Health Program at Boston Children's Hospital
"Novel Targets of Growth Plate Maturation from Genome-wide Functional CRISPR Screens"
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Hosted by the CCMBM and CSR
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May 22; Location and Time TBA
CCMBM Seminar Series
Join us in-person for May's seminar featuring visiting speaker Tom Nickolas, MD! Dr. Nickolas is Professor of Medicine in the Division of Nephrology at Columbia University Irving Medical Center. The location and time of Dr. Nickolas' seminar will be announced shortly.
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Resident
Department of Radiology & Biomedical Imaging
Award: JIC Travel Award
March 2024 – European Congress of Radiology
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Clinical Research Coordinator
Department of Radiology & Biomedical Imaging
Award: JIC Travel Award
April 2024 – OARSI World Congress on Osteoarthritis
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Postdoctoral Scholar
Department of Orthopaedic Surgery
Award: JIC Travel Award
May 2024 – PURPOSE Annual Meeting
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Rupsa Bhattacharjee, PhD
Associate Specialist
Radiology and Biomedical Imaging
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Laura Chen
Clinical Research Coordinator
Radiology and Biomedical Imaging
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Gabrielle Hoyer, MS
PhD Researcher
Radiology & Biomedical Imaging
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Sujit Kashyap, PhD
Postdoctoral Fellow
Pediatric Rheumatology
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Gurcharan Kaur, PhD
Postdoctoral Fellow
Orthopaedic Surgery
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Yurui Qian, PhD
Postdoctoral Scholar
Radiology & Biomedical Imaging
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Rafeek Thahakoya, PhD
Postdoctoral Fellow
Radiology & Biomedical Imaging
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Elizabeth "Betsy" Young, MD
Instructor
Pediatrics
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Jiamin Zhou, MS
Staff Research Associate III
Orthopaedic Surgery
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In case you missed it, the CCMBM Junior Investigator Committee hosted a hybrid workshop on March 27th. In collaboration faculty across multiple departments, the workshop featured presentations on translating research to clinical practice and commercial ventures. The workshop materials and recording are now available online. |
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In an effort to better collect an accurate list of CCMBM member publications, we are asking our members to please alert us to any submitted, accepted, or published manuscripts that either utilized CCMBM funding/core services or resulted from a collaboration with our membership.
Simply complete the our submission form and we will spotlight your publication in a future newsletter and on social media. We are excited to learn about your research!
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Application Deadline: May 1, 2024 by 5:00pm PST
The MSK T32 program is seeking applications for its next class of fellows who are eager to push the boundaries of MSK science, and in doing so, advance the field in fundamental ways. One-year training slots are available on a competitive basis to trainees proposing research in any area of musculoskeletal science, for projects across all UCSF campuses.
Applications may be submitted by email to Aaron Fields no later than 5:00 p.m. PST, on May 1, 2024. Early submission is encouraged. Awardees will be notified in late May 2024, and must start their fellowship before July 1, 2024.
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Eligibility and application requirements can be found in the RFA here. |
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Funded by the NIH as part of the HEAL Initiative/BACPAC Consortium, the Control Study is ancillary to our comeBACK observational study and will be used for Case-Control analyses to investigate predictors of cLBP, cLPB subtypes, and risk factors.
Eligible participants may receive up to $150 in total gift card for their time and effort by the end of the study.
Enrolled participants will participate in the following:
- 1 clinic visit at UCSF Mission Bay
- Physical exam, blood/stool/saliva collection, and MRIs of your low back
- Questions about your health, quality of life (QOL), & medications
- Wear motion sensors for 7 days
You may be eligible if you are:
- At least 18 years old
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Have NOT had treatment for low back pain or scoliosis, in the last 12 months (e.g., treatment = if you saw a physiotherapist, chiropractor, osteopath or medical doctor for the condition)
- Have NOT had ANY previous spine surgery, ever
- Have NOT had ANY hip or knee surgery, within the last 24 months
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Required Letter of Intent Deadline: May 16, 2024 at 12:00pm PDT
Letter of Intent Decision Date: June 6, 2024 (expected)
Full Proposal Deadline: August 8, 2024 at 12:00pm PDT
The MRPI opportunity is open to UC faculty and researchers in any field of research and scholarship. Proposals require collaboration among at least three UC campuses to pursue pioneering research in thematic, multidisciplinary, or inter-disciplinary areas that enhance the UC research enterprise, strengthen UC’s position as a leading public research university, and benefit California and its people. We anticipate approximately $16 million in total funding available across all awards.
For questions on program scope and priorities, please send an email to UCRI@ucop.edu.
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UCSF postdoctoral scholars are invited to apply for funds from a grant program made possible by support from the Program for Breakthrough Biomedical Research (PBBR). The program is designed to encourage creative and independent research driven by postdoctoral scholars in both basic and translational research. The grant will support UCSF postdocs who wish to explore biomedical research directions that are not directly linked to the research interests postdoctoral mentor and require the engagement of an additional collaborator or co-mentor.
Up to 14 grants will be awarded to provide the following funding for one year (August 2024 to August 2025): $15,000 research allowance for research supplies, meetings, courses, and other research expenses.
To learn more, view the proposal instructions here.
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To learn more, view the NOFO here.
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Recognizing the need for collaboration of MSK scientists with experts outside of the MSK field, we are providing support to MSK Center members to host a meal for a creative and enjoyable in-person networking meeting to stimulate these interactions and to further develop new research ideas and plans to fund them. Faculty, staff, and trainees who are MSKC/CCMBM members are encouraged to apply to host an event.
If you are not a member, you may concurrently apply for membership while your Open MIKE application is being reviewed.
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UCSF Talks is a new resource for anyone interested in learning about the latest seminars happening at UCSF. It lists all seminars open to the entire UCSF community including regular seminar series, special seminars, supergroups, and thesis talks. If you would like to receive weekly event listing emails, you can sign up for the USCF Talks Google Group. To add an event to the website, please contact Jon Zhang. |
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Core Center for Musculoskeletal Biology and Medicine (CCMBM), 513 Parnassus Avenue, S-1161, San Francisco, CA 94143 |
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