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New Research Scholar Martina Molgora Pursues Novel Target in Gastric Cancer

Shortly after she arrived at Washington University School of Medicine in St. Louis five years ago for her post-doctoral work, Martina Molgora, Ph.D., and her colleagues made a surprising discovery: An immune receptor known to play a role in Alzheimer’s disease is also prevalent in several types of cancer, including gastric cancer. Now she has an opportunity to learn more about the role of that receptor, called TREM2, in gastric cancer, thanks to a $300,000 research grant she has won from the Gastric Cancer Foundation and American Gastroenterology Association.

Molgora is the fourth recipient of The AGA–Gastric Cancer Foundation Ben Feinstein Memorial Research Scholar Award in Gastric Cancer, which provides $100,000 per year for three years to young scientists in the field of gastric and esophageal cancer research.

Molgora, who is from Milan, received her Ph.D. in immunology and immunopathology from Humanitas Research Hospital in Italy. She focused primarily on the role of natural killer (NK) cells in cancer. During her post-doc work at Washington University, she became interested in tumor-associated macrophages, which are immune cells that are prevalent in tumors.


TREM2 has been studied extensively in neurodegenerative diseases, but it wasn’t thought to be significant in cancer until next-generation cell-sequencing technologies revealed a possible role for the receptor in tumor growth a few years ago. Molgora led studies that demonstrated that blocking or deleting TREM2 could slow tumor growth.

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I’m truly honored to receive this grant and pursue the opportunity it offers... It’s important to find new therapies for gastric cancer, and I believe TREM2 might be a promising therapeutic target.


- Martina Molgora, Ph.D.



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Recent and Upcoming Events Benefitting Gastric Cancer Foundation

June 3, 2023

Swings for a Cause

Chicago, IL

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August 23-27, 2023

It Takes Guts Charity Pickleball Classic

Foley, AL

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October 21, 2023

Swim for Sara

San Francisco, CA

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If you are organizing an event for the Gastric Cancer Foundation, please let us know so we can publicize your efforts too!

Thank You to Our Newest National Sustaining Sponsor: Jazz Pharmaceuticals

We are excited to receive the support of our newest National Sustaining Sponsor, Jazz Pharmaceuticals. National sponsors are important partners in our work to raise awareness, support patients and expand research to find better treatments – and ultimately - a cure.

Research Roundup

There have been several exciting developments in gastric cancer research in the past few months, including these:


An experimental drug combining antibody fragments with engineered nanoparticle eliminated gastric cancer in mice, reported researchers from AstraZeneca, Memorial Sloan Kettering and Cornell. Startup Elucida Oncology is continuing the research.


Italian researchers reported in a study that gastric cancer patients with mutated BRCA2 or homologous repair deficiency may benefit from treatment with PARP inhibitors. They recommended that patients with a family history of gastric cancer be tested for BRCA2 mutations.


Researchers at Saint Louis University unveiled a link between gastric cancer risk and inflammation that’s typically associated with allergies and asthma. The researchers were awarded a four-year $2.2 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases to investigate further.

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