Dear Jeannette ,

Check out our latest WCMC Newsletter!

- WCMC Outreach Core

Using a new capsule invented by Dari Shalon at Envivo Bio, we have teamed up with Stanford University and explored the metabolome, proteome, and metagenome of four areas of the small intestine in 15 subjects over 48h duration. Check out our papers, including the effect of antibiotics that two subjects took up to 6 months before the sampling.

To read more click here

Shalon, D., et al. Profiling the human intestinal environment under physiological conditions. Nature (2023).

Folz, J., et al. Human metabolome variation along the upper intestinal tract. Nat Metab (2023).

From the Fiehn Lab

Dr. Min Liu - Postdoctoral Scholar

Dr. Huaxu Yu - Postdoctoral Scholar

From the UC Davis WCMC Core Lab

Jose Aguilar:

Lab Assistant 2

Zackery Hall:

SRA1, LC-MS Staff

Robert Williams:

SRA3, Targeted LC-MS Team Leader

Date: August 21 - September 1, 2023

Virtual Instructor-Led Course (Online)

This 2-week course will feature hands-on training with real-world untargeted metabolomics data covering all parts of the metabolomics workflow including:



• Study design, including pitfalls and hidden biases.
• Sample preparation and quality control
• Untargeted data processing and exercises on MS-DIAL.
• Exercises in the identification of unknowns by cheminformatics software workflows
• Data normalization and transformation with and without internal standards and quality controls
• Multivariate and univariate statistics 
• Pathway mapping and enrichment analysis

Bits & Bites #04: Using MS-DIAL to generate accurate comprehensive LC-MS/MS metabolomics datasets

May 25, 2023 @ 9 am - 1 pm PT

Instructor: Dr. Jacob Folz, ETH Zurich

About this course: Back by popular demand, this short course will focus on how to perform fine-tuned curation of processed LC-MS/MS data generated through MS-DIAL including compound identification, data quality analysis, and unknown feature reduction. Data from rat blood plasma analyzed using LC-MS/MS with MS/MS data collected in a data-dependent manner will be used to generate an example dataset, but the methods and techniques are applicable to many different sample types.

Bits & Bites #05: Identification of unknown compounds in untargeted metabolomics using freely available software is coming up on September 7, 2023

September 8, 2023

9 am to 2 pm PT

Register for free here

Hosted by UC Davis West Coast Metabolomics Center | Online

Come join us for the 5^th Annual MANA Fall Symposium, "Expanding the Exposome: The Power of Mass Spectrometry," which will feature an impressive lineup of speakers who will share their latest research and insights on how mass spectrometry can be used to explore the exposome, which includes all the environmental exposures that individual experiences throughout their life. The symposium will provide an excellent opportunity to learn about the latest advancements in the field and network with researchers and professionals working in the area of environmental health.

71^st ASMS Conference | Houston, Texas | June 4-8, 2023

• #315411, Oral presentation | June 7, 2023
• "Integrating quantification of low abundant targets into nontargeted LC-MS/MS screening using Simultaneous Quantitation and Discovery (SQUAD)" - Elys Rodriguez et al.
• #315595, Oral presentation | June 8, 2023
• "QA/QC for Untargeted Metabolomics in a Large Core Lab: Current Best Practices and Innovative Strategies" - Dr. Uri Keshet et al.
• #316015, Oral presentation | June 8, 2023
• "LibGen 2.0: fully automated pipeline for cleaning spectral libraries" - Fanzhou Kong et al.
• Speaker, Workshop | June 5, 2023
• "Exploring the World of Mass Spectral Libraries, Library Search Software and Their Applications"- Dr. Arpana Vaniya
• Organizer, Analytical Lab Managers Interest Group Workshop | June 5, 2023
• "Data quality in the core lab: Preventing, catching, reporting and sometimes even fixing! suboptimal 'bad data' in a omics core facility aka the 'Bad data Workshop'" - Presiding: Dr. Uri Keshet, Dr. Brett Phinney, Dr. Dave Quilici
• #490, Poster presentation | June 6, 2023
• "Comparing Targeted LC-MS/MS and Untargeted GC-MS for the analysis of Kynurenine Pathway in Plasma Samples" - Luis Valdiviez et al.
• #571, Poster presentation | June 7, 2023
• "Combined GC-TOF-MS and LC-TOF-MS/MS Untargeted Metabolomics Yields Insight into Pathophysiology of Parkinson’s Disease" - Jeremiah Wells et al.

HPLC 2023 | Duesseldorf, Germany | June 18-22, 2023

• Short Course | June 18, 2023
• "Metabolomics – from study designs to data interpretation" - Dr. Oliver Fiehn

19^th Annual Conference of the Metabolomics Society | Niagara Falls, Canada | June 18-22, 2023

• #463, Oral presentation | June 20, 2023
• "The Periodic Table of Food Initiative Enables Standardized Metabolomics for Global Food Analysis"- Dr. Arpana Vaniya et al.

• Shalon, D., et al. Profiling the human intestinal environment under physiological conditions. Nature (2023).
• Folz, J., et al. Human metabolome variation along the upper intestinal tract. Nat Metab (2023).
• Hricko, J., et al. "Short-Term Stability of Serum and Liver Extracts for Untargeted Metabolomics and Lipidomics." Antioxidants 12.5 (2023): 986.
• Miao, G., et al. "Longitudinal lipidomic signatures of all-cause and CVD mortality in American Indians: findings from the Strong Heart Study." GeroScience (2023): 1-19.
• Dhillon, J., et al. "Almond Consumption for 8 Weeks Altered Host and Microbial Metabolism in Comparison to a Control Snack in Young Adults." Journal of the American Nutrition Association 42.3 (2023): 242-254.

UC Davis West Coast Metabolomics Center

451 Health Sciences Dr. Rm 1313

Davis, CA 95616

Phone: (530) 752-8129

If you have any questions contact us: wcmetabolomics@gmail.com