The RNA Transcript, May 1st 2023 | | |
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miRNA-based logic circuits and small molecule control encoded on self-amplifying RNA for highly specific cancer immunotherapy
Ron Weiss, Ph.D.
Professor of Biological Engineering & Director of the Synthetic Biology Center
Massachusetts Institute of Technology
Tuesday, May 2, 2023 at 3:00 PM EST
CLS 421 or to Join Virtually Register Here
Please reach out to Grace Lee at glee8@bidmc.harvard.edu for any questions
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Science Café: The Future of mRNA Vaccines
Rachel Niederer, Ph.D.
Assistant Professor Biological Chemistry
Medical School
Nils Walter, Ph.D.
Professor of Chemistry & Biophysics
College of LSA
Wednesday, May 3, 2023
5:30 - 7:30 PM
Conor O'Neill's Traditional Irish Pub
318 South Main Street, Ann Arbor MI
Complimentary hors d’oeuvres at 5:30 p.m.
The program begins at 6:00 p.m.
Seating is limited—come early.
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U-M RNA Innovation Seminar | | |
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Talk Title TBA
Lydia Contreras, Ph.D.
Professor
Paul D & Betty Robertson Meek Centennial Professorship in Chemical Engineering
Biotechnology
Environmental Engineering
Modeling & Simulation
Monday, May 8, 2023
2:00 - 3:00 PM
Palmer Commons, Great Lakes North, Zoom
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RNA Collaborative Seminar | | |
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Quantitative Techniques to Study Cancer Metabolism In-Vivo
Anjali Mittal, Advisors: D. Nagrath
Tuesday, May 2, 2023.
10:00 AM - 11:00 AM
NCRC10 G065
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Investigating Spatial Organization & Physicochemical Interactions in Biomembranes: Tools & Insights
Thomas Shaw, Advisors: S. Veatch
Wednesday, May 3, 2023.
9:00 AM - 10:00 AM
Rackham East Conference Room
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Lexogen RNA Expertise Blog Series | | |
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We are happy to introduce you to the LEXOGEN RNA EXPERTISE blog series, in which we will talk about various topics from the world of RNA and RNA-Seq, focusing on best practices, exciting applications, and more.
Inspired by the RNA journal's April 2023 special edition, we dedicate our newest blog post to RNA therapeutics.
RNA Therapeutics: The Future is Bright
RNA therapeutics are a rapidly expanding category of drugs based on RNA molecules aimed at treating or preventing diseases. Recent clinical success and primarily the breakthrough of a series of fast-tracked and effective messenger RNA (mRNA)-based vaccines helping to conquer the COVID-19 pandemic did not only make “RNA” a household name but also reignited and propelled research interest in RNA therapeutics.
This blog article will discuss the advantages of RNA therapeutics, concepts, and modes of action of different classes of RNA-based therapeutics. We will also give a glimpse into the RNA therapeutics currently being evaluated in clinical trials or having received approval.
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28th Annual Meeting of the RNA Society: May 30th thru June 4th | |
Post-doctoral Scholars - Weiss Laboratory | | |
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Postdoctoral scholars:
The Weiss lab at MIT is looking for talented researchers in the field of synthetic biology and has openings for postdoctoral researchers in the following areas:
Researchers will design and build genetic circuits that sense cell state, including mRNA, miRNA, metabolites, viral entry, etc., and implement feedback control, analog, digital, and “neural” logic functions that result in precise spatiotemporal responses, such as transcription factors for differentiation, antiviral therapy, vascularization, cell-cell communication, 3D tissue formation, synthetic immune systems, and more. Follow the links below to apply for the current openings.
20458, Postdoctoral Associate, Immunology, Weiss Lab
https://careers.peopleclick.com/careerscp/client_mit/external/jobDetails/jobDetail.html?jobPostId=22359&localeCode=en-us
Send a cover letter and CV to Professor Weiss at rweiss@mit.edu
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Michigan Pioneer Fellows Program | | |
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Pioneer Fellows Program:
The Michigan Pioneer Fellows program at the University of Michigan provides exceptional postdoctoral scholars with a unique, multidisciplinary community focused on nurturing & launching truly innovative scientists into groundbreaking careers.
In this highly competitive "super-postdoc" program, fellows receive funding to pursue independent research, as well as strong mentorship, skill-building & Additional resources.
This partnership between the U-M Life Science Institute, Medical School, College of Pharmacy, & College of LSA, is designed to enhance the research program of the entire life sciences enterprise across the university & to help train & develop the next generation of scientific leaders.
The 2023 Timeline:
April 17th: Open for submission
August 4th: Deadline for application
Appointment start date is flexible
For more information about the program & how to apply, visit: Pioneerfellows.umich.edu
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Post-doctoral Fellows - Markovitz Laboratory | | |
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The Markovitz laboratory is looking to add post-doctoral fellows to its ongoing efforts to explore basic disease mechanisms and devise new therapeutic strategies. We are looking for independent and motivated individuals who would like to work at the convergence of virology, cancer immunotherapy, and glycobiology. The glycobiology projects could involve studies of RNA if it suits the fellow’s interests. Housed in Internal Medicine, the Markovitz laboratory is also affiliated with programs in Molecular and Cellular Biology, Cancer Biology, and Immunology. Diversity in all respects is welcomed.
Interested candidates should forward a résumé and the names of three potential references to David Markovitz at dmarkov@umich.edu
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Abstract: “RNA therapeutics” refers to a disease treatment or drug that utilizes RNA as a component. In this context, RNA may be the direct target of a small-molecule drug or RNA itself may be the drug, designed to bind to a protein, or to mimic or target another RNA. RNA has gained attention in the drug-development world, as recent clinical successes and breakthrough technologies have revolutionized the drug-like qualities of the molecule or its usefulness as a drug target. In this special issue of RNA, we gathered expert perspectives on the past, present, and future of the field, to serve as a primer and also a challenge to the broad scientific community to incorporate RNA into their experimental design and problem-solving process, and to imagine and realize the potential of RNA as a therapeutic drug or target.
Michelle L. Hastings1 and Adrian R. Krainer2
Corresponding author: krainer@cshl.edu
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RNA Function Trainee Networking Event: May 17 2023 | | |
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The Center for RNA Biomedicine's Student and Postdoc Council is hosting the second annual RNA Function event on Wednesday, May 17 from 11 AM to 2 PM in the BSRB ABC Seminar Rooms.
This is a low-stress environment where we invite trainees of all levels who are interested in RNA biology to come together to make connections with other trainees from across the university. The event will include a casual poster session as well as facilitated networking, with lunch provided for registered participants.
Please register here by May 10. We are looking forward to seeing you there!
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Congratulation Jingxuan Tang - PPG Summer Research Fellowship Award | | |
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Jingxuan Tang has been selected as the department winner for the PPG Summer Research Fellowship Award.
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Biophysical Society - Postdoctoral Reviewer Program | | |
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Biophysical Journal is accepting applications from postdocs who are members of The Biophysical Society to be Postdoctoral Reviewers. Successful Applicants will be paired with an Editor of the journal working in your research area to receive guidance and mentorship in learning how to review articles submitted for consideration by the journal. This program will give postdocs the opportunity to engage with the editorial board of the Biophysical Society’s flagship journal and to learn how to provide a complete and useful review of a paper, an essential task that contributes to the biophysics community.
Applications are due by July 1, 2023 for selected individuals to begin reviewing in September 2023.
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Cold Spring Harbor (CSH) Asia Meeting June 19 - 23 | | |
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The Cold Spring Harbor (CSH) Asia meeting on The Now and Future of RNA Therapeutics: will be held June 19th-23rd, 2023 at the Awaji Yumebutai Conference Center in Awaji, Japan.
Please see the attached flyer and visit the website for full details, including travel information, venue, and accommodations: https://www.csh-asia.org/?content/1309
Abstracts are due: May 5th
Submit your abstract here: https://cshl.csh-asia.org/abstractsubchina/abstractsub.aspx
Keynote Speakers:
Lynne Maquat, University of Rochester Medical Center
Chuan He, University of Chicago
Don Cleveland, University of California San Diego
Tsutomu Suzuki, The University of Tokyo
Invited Speakers:
Isabel Aznarez, Stoke Therapeutics
Vinod Balachandran, Memorial Sloan Kettering Cancer Center
Zicai Liang, Suzhou Ribo Life Science
Jinzhong Lin, Fudan University
Hiroshi Nishimasu, The University of Tokyo
Daniel Siegwart, UT Southwestern Medical Center
Osamu Takeuchi, Kyoto University
Willeke van Ron-Mom, Leden University Medical Centre
Takeshi Wada, The University of Tokyo
Yanli Wang, Institute of Biophysics, CAS
Ligang Wu, Shanghai Institute of Biochemistry and Cell Biology, CAS
Yuanchao Xue, Institute of Biophysics, CAS
Chengqi Yi, Peking University
Chen-Yu Zhang, Nanjing University
Qiangfeng Cliff Zhang, Tsinghua University
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Interacademy Conference Wurzburg Germany September 20 - 22 | | |
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"Microbiology: from single cell to microbiome and host” on September 20-22, 2023 in Würzburg, Germany.
This conference on molecular microbiology will be organized by the German National Academy of Sciences Leopoldina, the Académie des sciences, the Royal Society, and the Royal Swedish Academy of Sciences.
Hosted by the University of Würzburg and supported by the Helmholtz Institute Würzburg and the Krupp Foundation, the 2-day conference is the sequel to several successful and exceptionally well-attended Interacademy meetings on the topic that were held in Paris (2014) and London (2016).
For further information, including the line-up of our 22 outstanding speakers, as well as the registration and abstract submission process, please visit the conference website www.microbiology2023.de
Register by: July 31st, 2023 (without abstract: end of August 2023).
We can accommodate up to 250 participants, so please try to register early. If you have any questions, please do not hesitate to contact us at stefanie.ziegler@helmholtz-hiri.de.
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2023 RiboClub Annual Meeting: September 24 - 28 | | |
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The RiboClub Annual Meeting aims at encouraging the exchange of ideas and stimulates collaborations between RNA biologists around the world. The meeting covers different topics related to the chemistry, structure and biology of RNA with emphasis on upcoming and debatable biological questions. In addition, every year the RiboClub puts the focus on a local or regional RNA group to highlight their efforts and introduce them to the international community.
The meeting format provides principal investigators the opportunity to present their point of views on the current state of knowledge and ignite the curiosity of young scientists. The meeting size and its format give ample opportunity for discussions and interactions, so bring your thinking hat to uncover the next big idea.
Registration fees are subsidized to encourage the participation of students and upcoming researchers. All laboratory members are invited to attend, listen to the presentations of leading scientists and participate in poster competition.
Annual Meeting September 24-28, 2023
Chéribourg Hotel, Orford, Quebec, Canada
Register by: June 30th, 2023
More Inforamtion :www.riboclub.org
Questions: riboclub@riboclub.org
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Our members' publications are available through Altmetrics. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation.
Below are recent highlights.
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Mustoe AM, Weidmann CA, Weeks KM. Single-Molecule Correlated Chemical Probing: A Revolution in RNA Structure Analysis. Acc Chem Res. 2023 Apr 4;56(7):763-775. doi: 10.1021/acs.accounts.2c00782. Epub 2023 Mar 14. PMID: 36917683; PMCID: PMC10078950. https://pubs.acs.org/doi/10.1021/acs.accounts.2c00782 | |
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Mandal, S., Khanna, K., Johnson-Buck, A., & Walter, N. G. (2022). A guide to accelerated direct digital counting of single nucleic acid molecules by FRET-based intramolecular kinetic fingerprinting. Methods (San Diego, Calif.), 197, 63–73. Highlighted in NCI's Epidemiology & Genomics Research Program (EGRP) https://doi.org/10.1016/j.ymeth.2021.06.014
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Wang, E. T., Freudenreich, C. H., Gromak, N., Jain, A., Todd, P. K., & Nagai, Y. (2023). What repeat expansion disorders can teach us about the Central Dogma. Molecular cell, 83(3), 324–329. https://doi.org/10.1016/j.molcel.2022.12.017 | | | | |
