Background: Youth with schizophrenia have a high risk of suicide and suicidal behaviors. Risk factors for suicide attempts and dying by suicide in individuals with schizophrenia include history of suicidal ideation, prior self-harm behaviors, previous depression episodes, substance use, poor medication adherence, and previous hospitalizations. Previous studies have found that early psychosis intervention programs have successfully reduced suicidal attempts but have less evidence for reducing death by suicide. The Early Assessment Service for Young People with Psychosis (EASY) program is a 2-year intervention program for individuals aged 15 -25 in Hong Kong. This study was a 12-year large-scale retrospective cohort study in Hong Kong whose aim was to explore the association between early psychosis intervention programs and suicide rates.
Methods: A total of 617 youth diagnosed with a schizophrenia-spectrum disorder enrolled in the EASY program from 2001 to 2003 were included in the study. The same number of sex, diagnosis, and age-matched controls receiving standard psychiatric services from 1998 to 2001 served as the control group. All deaths in the cohort during the 12-year follow-up period were recorded using a centralized clinical database of the Hong Kong hospital system. Deaths resulting from intentional self-harm or undetermined intent were coded as a suicide. Suicide survival was defined as the elapsed time between entry into the program and the date of suicide death.
Findings: A total of 1,234 persons were included in the analysis, with 617 people in each group. Overall, 73 youth (5.9%) died by suicide during the 12-year follow-up, including 27 (4.4%) in the EASY program and 46 (7.5%) in the standard care group (p = 0.02). Youth who participated in the EASY program had significantly fewer suicides and longer life expectancy, particularly during the first three years compared to those who received general services.
Limitations: The reliability of the suicide data used in this study depends on the quality of the clinical records, which are likely to differ between the two groups, limiting interpretations of the findings. Given the retrospective study design, causality cannot be determined between program participation and suicide reductions. Findings also have limited generalizability for persons with different diagnoses, duration of treatment, and ages than those included in the study.
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