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From AI to gene regulation:
Nobel-winning discoveries show RNA’s far-reaching influence
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This year's Nobel Prizes in Physics, Chemistry, and Physiology or Medicine illustrate RNA’s profound impact across diverse scientific fields. The artificial neural networks pioneered by John Hopfield and Geoffrey Hinton intersect with David Baker's computational protein design and DeepMind's structural predictions by Demis Hassabis and John Jumper. These advancements align with Victor Ambros and Gary Ruvkun’s discovery of microRNA in gene regulation.
At the University of Michigan Center for RNA Biomedicine, our collaborative research environment reflects this global intersection of disciplines, driving biomedical innovations.
Read more about this synergy of events in an in-depth article by Paul Avedisian on our website.
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2024
Nobel Prize in Physiology
or Medicine
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The Nobel Prize in Physiology or Medicine 2024 was awarded jointly to Victor Ambros and Gary Ruvkun "for the discovery of microRNA and its role in post-transcriptional gene regulation".
Learn more about this year's winner of the Nobel Prize in Physiology or Medicine in this official Nobel Foundation press release.
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2024
Nobel Prize in Chemistry
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The Nobel Prize in Chemistry 2024 was divided, one half awarded to David Baker "for computational protein design", the other half jointly to Demis Hassabis and John M. Jumper "for protein structure prediction."
Learn more about this year's winner of the Nobel Prize in Chemistry in this official Nobel Foundation press release.
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2024
Nobel Prize in Physics
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The Nobel Prize in Physics 2024 was awarded jointly to John J. Hopfield and Geoffrey E. Hinton "for foundational discoveries and inventions that enable machine learning with artificial neural networks."
Learn more about this year's winner of the Nobel Prize in Physics in this official Nobel Foundation press release.
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Faculty perspective on the 2024 Nobel Prize in Chemistry: | | | |
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“Cancer research has largely focused on transcription factors as key tumor suppressors or oncogenes. I hope this recognition will reinvigorate the field, shifting attention to these vital genetic regulators and driving greater support for miRNA-based therapies.”
Analisa DiFeo, Ph.D.
Professor, Pathology, Obstetrics & Gynecology
Associate Director, Cancer Biology Graduate Program
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2025 Symposium registration is now open! | |
Congratulations, Dr. Kalantry! | |
Sundeep Kalantry, Ph.D., wins NIH Director’s Transformative Research Award | Dr. Kalantry is one of three U-M investigators recognized by the National Institute of Health's High-Risk, High-Reward Research program. Read the full Michigan Medicine article by Kelly Malcom. | “This award will help us define novel factors and mechanisms that equalize gene expression between the sexes. Understanding how the two sexes reach X chromosome gene expression equality not only reveals how female and male cells manage differences in their sex chromosomes but more generally informs how cells equalize gene expression despite differences in chromosome number, for example in disorders with aneuploidies.” —Dr. Kalantry. | |
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Our members' publications are available through Altmetric.
Queries currently available:
CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation. Below are recent highlights.
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Shaw EA, Thomas NK, Jones JD, Abu-Shumays RL, Vaaler AL, Akeson M, Koutmou KS, Jain M, Garcia DM. Combining Nanopore direct RNA sequencing with genetics and mass spectrometry for analysis of T-loop base modifications across 42 yeast tRNA isoacceptors. Nucleic Acids Res. 2024 Sep 28:gkae796. doi: 10.1093/nar/gkae796. Epub ahead of print. PMID: 39340295.
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Wang J, Palomar VM, Min JH, Wierzbicki AT. PAP1 and PAP7 are required for association of plastid-encoded RNA polymerase with DNA. Plant Mol Biol. 2024 Sep 20;114(5):100. doi: 10.1007/s11103-024-01498-x. PMID: 39302509.
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Monroe J, Eyler DE, Mitchell L, Deb I, Bojanowski A, Srinivas P, Dunham CM, Roy B, Frank AT, Koutmou KS. N1-Methylpseudouridine and pseudouridine modifications modulate mRNA decoding during translation. Nat Commun. 2024 Sep 16;15(1):8119. doi: 10.1038/s41467-024-51301-0. PMID: 39284850; PMCID: PMC11405884.
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Havens MA, Hinrich AJ, Rigo F, Hastings ML. Increasing MicroRNA Abundance by Targeting Biogenesis from the Primary Transcript with Steric-Blocking Antisense Oligonucleotides. RNA. 2024 Sep 10:rna.080021.124. doi: 10.1261/rna.080021.124. Epub ahead of print. PMID: 39255995.
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"Combating Treatment Resistance in H3K27M-mutant Diffuse Midline Glioma"
Erik Peterson, Cancer Biology
TODAY, Monday, October 14 | 2 p.m.
Kahn Auditorium | BSRB
Advisor: Maria Castro, Ph.D.
| RNA Collaborative Lightning Talk Workshop: Engaging Others In Your Research | |
Are you excited about your research and eager to improve your presentation skills? Learn to create inclusive and engaging presentations for diverse audiences. Whether you’re experienced or new, discover best practices and sharpen your skills. This workshop series is held via Zoom and open to all program levels.
Visit the RNA Collaborative website for info on October 16, 23 & 30 workshops.
The registration site for these workshops is now closed. Please reach out directly to Stacey O’Neil with any questions.
Thank you for your interest!
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Meetings:
For all details regarding each upcoming meeting, please click the banners below.
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UMass Chan Early Independence Fellows Program
seeks talented junior researchers
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An upcoming informational webinar will be held to answer questions or watch the previously recorded session from October 2. | |
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The Training Program in Tumor Microenvironment seeks pre- and postdoctoral trainees | |
U-M Medical School seeks applicants for Research Operations, Management & Strategy Fellowship | |
TPTM is pleased to request applications for pre-doctoral and postdoctoral trainee appointments. The appointment is expected to begin September 1, 2024 and will be backdated. More details, including eligibility requirements, details of support, and the application information can be found in the Competition Space application. | |
All application materials should be submitted through the application in Competition Space and are due by Monday, October 21.
If you have any questions, please contact Maria Castro, Ph.D. (mariacas@umich.edu) or Analisa DiFeo, Ph.D. (adifeo@med.umich.edu)
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The Research Operations, Management & Strategy (ROMS) Fellowship is a two-year, paid, full-time position at the University of Michigan Medical School in Ann Arbor, MI. The fellowship provides a unique and valuable experience for biomedical Ph.D. graduates and postdoctoral trainees looking to transition from the research bench to rewarding careers in research operations and administration.
In-person information session:
Wednesday, October 30, 2024 | 3:30 p.m.
Taubman Health Sciences Library (THSL) 5320
Snacks and refreshments will be provided.
Here is the link to RVSP. Please complete the form to RSVP by October 28, 2024.
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