July 2021 The Science Spotlight newsletter features publications from Brigham researchers in high-impact journals. Recognizing that journal impact factor is not an absolute way to feature all scientific publications of significant merit, we welcome investigators to submit noteworthy articles to be featured in the newsletter through this survey. *The gold colored buttons denote COVID-19 related publications.

In June there were: 1,201 total papers listed in PubMed with Brigham authors 48 tweets about new research and 65.2K tweet impressions 3 press releases 8 research briefs 8 papers highlighted in "What's New in Research" 64 awards with $34,875,720 in new grants

A Reminder from the Office of Strategic Communication: If you have research news to share, please contact us. Ideally, we work with researchers as soon as a paper is accepted at a journal to develop an appropriate communication strategy in advance of publication. For media relations and social media support, email mediarelations@bwh.harvard.edu or contact Haley Bridger directly at hbridger@bwh.harvard.edu Listen to the recording of the June RC LIVE Meeting, "What Makes the News for Researchers," with Haley Bridger. Listen to the recording here.

Dermatomyositis. O'Connell KA, LaChance AH. N Engl J Med. 2021 Jun 24;384(25):2437. doi: 10.1056/NEJMicm2033425. PMID: 34161709 No abstract available.

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Acquired Resistance to KRASG12C Inhibition in Cancer. Awad MM, Liu S, Rybkin II, Arbour KC, Dilly J, [et al.] Aguirre AJ. N Engl J Med. 2021 Jun 24;384(25):2382-2393. doi: 10.1056/NEJMoa2105281. PMID: 34161704

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Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity. Mwakingwe-Omari A, Healy SA, Lane J, Cook DM, Kalhori S, [et al.] Duffy PE. Nature. 2021 Jul;595(7866):289-294. doi: 10.1038/s41586-021-03684-z. Epub 2021 Jun 30. PMID: 34194041

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PD-L1 as a biomarker of response to immune-checkpoint inhibitors. Doroshow DB, Bhalla S, Beasley MB, Sholl LM, Kerr KM, [et al.] Hirsch FR. Nat Rev Clin Oncol. 2021 Jun;18(6):345-362. doi: 10.1038/s41571-021-00473-5. Epub 2021 Feb 12. PMID: 33580222 Review.

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Interleukins in cancer: from biology to therapy. Briukhovetska D, Dörr J, Endres S, Libby P, Dinarello CA, Kobold S. Nat Rev Cancer. 2021 Jun 3:1-19. doi: 10.1038/s41568-021-00363-z. Online ahead of print. PMID: 34083781 Free PMC article. Review.

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TIM-3 restrains anti-tumour immunity by regulating inflammasome activation. Dixon KO, Tabaka M, Schramm MA, Xiao S, Tang R, [et al.] Kuchroo VK. Nature. 2021 Jul;595(7865):101-106. doi: 10.1038/s41586-021-03626-9. Epub 2021 Jun 9. PMID: 34108686

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Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): health status analysis of a randomised, double-blind, placebo-controlled, phase 3 trial. Spertus JA, Fine JT, Elliott P, Ho CY, Olivotto I, [et al.] Jacoby D. Lancet. 2021 Jun 26;397(10293):2467-2475. doi: 10.1016/S0140-6736(21)00763-7. Epub 2021 May 15. PMID: 34004177

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Hypertensive Heartbreak. Lau ES, Scirica B, Schaefer IM, Miller AL, Loscalzo J. N Engl J Med. 2021 Jun 3;384(22):2145-2152. doi: 10.1056/NEJMcps2018493. PMID: 34077647 No abstract available.

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B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV. Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, [et al.] Xavier RJ. Cell. 2021 Jun 10;184(12):3205-3221.e24. doi: 10.1016/j.cell.2021.04.032. Epub 2021 Apr 24. PMID: 34015271 Free PMC article.

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AI-based pathology predicts origins for cancers of unknown primary. Lu MY, Chen TY, Williamson DFK, Zhao M, Shady M, Lipkova J, Mahmood F. Nature. 2021 Jun;594(7861):106-110. doi: 10.1038/s41586-021-03512-4. Epub 2021 May 5. PMID: 33953404

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Women's Health - Traversing Medicine and Public Policy. Stuenkel CA, Manson JE. N Engl J Med. 2021 Jun 3;384(22):2073-2076. doi: 10.1056/NEJMp2105292. Epub 2021 May 29. PMID: 34080809 No abstract available.

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Dietary omega 3 fatty acids for migraine. Burch R. BMJ. 2021 Jun 30;374:n1535. doi: 10.1136/bmj.n1535. PMID: 34193458 No abstract available.

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Acute Treatment for Migraine: Contemporary Treatments and Future Directions. Burch R, Rayhill M. JAMA. 2021 Jun 15;325(23):2346-2347. doi: 10.1001/jama.2021.7275. PMID: 34129013 No abstract available.

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Chemoproteomic methods for covalent drug discovery. Chan WC, Sharifzadeh S, Buhrlage SJ, Marto JA. Chem Soc Rev. 2021 Jun 18. doi: 10.1039/d1cs00231g. Online ahead of print. PMID: 34143170

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The origin of human mutation in light of genomic data. Seplyarskiy VB, Sunyaev S. Nat Rev Genet. 2021 Jun 23. doi: 10.1038/s41576-021-00376-2. Online ahead of print. PMID: 34163020 Review.

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Metabolic modeling of single Th17 cells reveals regulators of autoimmunity. Wagner A, Wang C, Fessler J, DeTomaso D, Avila-Pacheco J, [et al.] Yosef N. Cell. 2021 Jun 29:S0092-8674(21)00700-5. doi: 10.1016/j.cell.2021.05.045. Online ahead of print. PMID: 34216539

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Computationally guided high-throughput design of self-assembling drug nanoparticles. Reker D, Rybakova Y, Kirtane AR, Cao R, Yang JW, [et al.] Traverso G. Nat Nanotechnol. 2021 Jun;16(6):725-733. doi: 10.1038/s41565-021-00870-y. Epub 2021 Mar 25. PMID: 33767382

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Risk of Breast Cancer Among Carriers of Pathogenic Variants in Breast Cancer Predisposition Genes Varies by Polygenic Risk Score. Gao C, Polley EC, Hart SN, Huang H, Hu C, [et al.] Kraft P. J Clin Oncol. 2021 Jun 8:JCO2001992. doi: 10.1200/JCO.20.01992. Online ahead of print. PMID: 34101481

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Kirigami-inspired stents for sustained local delivery of therapeutics. Babaee S, Shi Y, Abbasalizadeh S, Tamang S, Hess K, [et al.] Traverso G. Nat Mater. 2021 Jun 14. doi: 10.1038/s41563-021-01031-1. Online ahead of print. PMID: 34127823

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Review of Hip and Knee Osteoarthritis-Reply. Katz JN, Arant K, Loeser RF. JAMA. 2021 Jun 22;325(24):2505. doi: 10.1001/jama.2021.6024. PMID: 34156413 No abstract available.

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Payer-Negotiated Prices in the Diagnosis and Management of Thyroid Cancer in 2021. Xiao R, Rathi VK, Gross CP, Ross JS, Sethi RKV. JAMA. 2021 Jun 4;326(2):184-5. doi: 10.1001/jama.2021.8535. Online ahead of print. PMID: 34086052

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Estimating epidemiologic dynamics from cross-sectional viral load distributions. Hay JA, Kennedy-Shaffer L, Kanjilal S, Lennon NJ, Gabriel SB, Lipsitch M, Mina MJ. Science. 2021 Jun 3:eabh0635. doi: 10.1126/science.abh0635. Online ahead of print. PMID: 34083451

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Elective Pelvic Lymph Node Radiation in Prostate Cancer Revisited. Yang DD, Nguyen PL, D'Amico AV. J Clin Oncol. 2021 Jun 4:JCO2100621. doi: 10.1200/JCO.21.00621. Online ahead of print. PMID: 34086490 No abstract available.

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Does Sleep Flush Wastes From the Brain? Komaroff AL. JAMA. 2021 Jun 1;325(21):2153-2155. doi: 10.1001/jama.2021.5631. PMID: 33999096 No abstract available.

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Anticoagulation in COVID-19: reaction to the ACTION trial. Berger JS, Connors JM. Lancet. 2021 Jun 12;397(10291):2226-2228. doi: 10.1016/S0140-6736(21)01291-5. PMID: 34119049 Free PMC article. No abstract available.

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Association of California's Prescription Drug Coupon Ban With Generic Drug Use. Rome BN, Gagne JJ, Kesselheim AS. JAMA. 2021 Jun 15;325(23):2399-2402. doi: 10.1001/jama.2021.6568. PMID: 34129007

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Interventions for Patients With Secondary Mitral Regurgitation. Hirji S, Cifu AS, Kaneko T. JAMA. 2021 Jun 8;325(22):2309-2310. doi: 10.1001/jama.2021.2741. PMID: 34100880 No abstract available.

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Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants. Cai Y, Zhang J, Xiao T, Lavine CL, Rawson S, [et al.] Chen B. Science. 2021 Jun 24:eabi9745. doi: 10.1126/science.abi9745. Online ahead of print. PMID: 34168070

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Adjuvant Versus Early Salvage Radiation Therapy for Men at High Risk for Recurrence Following Radical Prostatectomy for Prostate Cancer and the Risk of Death Tilki D, Chen MH, Wu J, Huland H, Graefen M, [et al.] D'Amico AV. J Clin Oncol. 2021 Jul 10;39(20):2284-2293. doi: 10.1200/JCO.20.03714. Epub 2021 Jun 4. PMID: 34086480

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Predictors for single-agent resistance in FIGO score 5 or 6 gestational trophoblastic neoplasia: a multicentre, retrospective, cohort study. Braga A, Paiva G, Ghorani E, Freitas F, Velarde LGC, [et al.] Seckl MJ. Lancet Oncol. 2021 Jun 25:S1470-2045(21)00262-X. doi: 10.1016/S1470-2045(21)00262-X. Online ahead of print. PMID: 34181884

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Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease. Scott BM, Gutiérrez-Vázquez C, Sanmarco LM, da Silva Pereira JA, Li Z, [et al.] Quintana FJ. Nat Med. 2021 Jul;27(7):1212-1222. doi: 10.1038/s41591-021-01390-x. Epub 2021 Jun 28. PMID: 34183837

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Polyamine metabolism is a central determinant of helper T cell lineage fidelity. Puleston DJ, Baixauli F, Sanin DE, Edwards-Hicks J, Villa M, [et al.] Pearce EL. Cell. 2021 Jun 25:S0092-8674(21)00708-X. doi: 10.1016/j.cell.2021.06.007. Online ahead of print. PMID: 34216540

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Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection. Zekavat SM, Lin SH, Bick AG, Liu A, Paruchuri K, [et al.] Natarajan P. Nat Med. 2021 Jun;27(6):1012-1024. doi: 10.1038/s41591-021-01371-0. Epub 2021 Jun 7. PMID: 34099924

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Other Featured Publications

Diabetic cataract in the Nile grass rat: A longitudinal phenotypic study of pathology formation Ranaei Pirmardan E, Barakat A, Zhang Y, Naseri M, Hafezi-Moghadam A. FASEB J. 2021 Jun;35(6):e21593. doi: 10.1096/fj.202100353R. PMID: 33991133.

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Sex chromosome transformation and the origin of a male-specific X chromosome in the creeping vole. Couger MB, Roy SW, Anderson N, Gozashti L, Pirro S, [et al.] Campbell P. Science. 2021 May 7;372(6542):592-600. doi: 10.1126/science.abg7019. PMID: 33958470.

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Diabetes Risk Reduction Diet and Survival After Breast Cancer Diagnosis. Wang T, Farvid MS, Kang JH, Holmes MD, Rosner BA, [et al.] Eliassen AH. Cancer Res. 2021 Jun 9:canres.0256.2021. doi: 10.1158/0008-5472.CAN-21-0256. Epub ahead of print. PMID: 34108141.

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Adaptive adversarial neural networks for the analysis of lossy and domain-shifted datasets of medical images. Kanakasabapathy MK, Thirumalaraju P, Kandula H, Doshi F, Sivakumar AD, [et al.] Shafiee H. Nat Biomed Eng. 2021 Jun;5(6):571-585. doi: 10.1038/s41551-021-00733-w. Epub 2021 Jun 10. PMID: 34112997.

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A Dual-Route Perspective of SARS-CoV-2 Infection: Lung- vs. Gut-specific Effects of ACE-2 Deficiency. Sajdel-Sulkowska EM. Front Pharmacol. 2021 Jun 11;12:684610. doi: 10.3389/fphar.2021.684610. PMID: 34177593; PMCID: PMC8226136.

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Restored TDCA and valine levels imitate the effects of bariatric surgery.

Quante M, Iske J, Heinbokel T, Desai BN, Cetina Biefer HR, [et al.] Tullius SG. Elife. 2021 Jun 22;10:e62928. doi: 10.7554/eLife.62928. PMID: 34155969; PMCID: PMC8257250.

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Submit Your Publication to Science Spotlight We recognize there are many other Brigham publications in Journals that may not be included on this list, so we would like to extend the opportunity to our research community. If you and/or your Brigham colleagues are the first and/or last author on a recent publication, we want to include you in our Science Spotlight newsletter! Please fill out this brief REDCap form with the details of your publication.

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