The RNA Transcript, June 13, 2022 |
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On Thursday, June 9 thirty-five students and postdocs representing nine departments and programs across Central campus and the Medical School met for the inaugural RNA Function: a networking event for trainees, by trainees. The goal of The RNA Function was to connect students and postdocs from across the university in an informal and low-risk environment to hear what other groups are doing around campus. The event included a poster session, catered lunch, and a facilitated "scientific speed-dating" networking event. Feedback from participants include:
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“My favorite part of the day was meeting new people and catching up with the people I know but don't see often because we work in different buildings”
“It was really nice to actually talk with almost all the people who attended today!”
“It was good that we were "forced" to interact with new people instead of sticking with people in our existing comfort zone.”
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The RNA Function was sponsored by The RNA Society. The U-M RNA Student and Postdoc Council wishes to give a big thanks to all of the attendees for coming out and contributing to this successful event! Stay tuned for further events in the next academic year!
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Yaping Liu is a postdoc in the Sarah Keane Lab. Her research interests lie in understanding the molecular basis of noncoding RNA function by solving high-resolution structures at different stages using NMR, Cryo-EM, and other imaging approaches. She hopes her work on the structure of RNA can provide the atomic basis for understanding RNA function and designing inhibitors specifically targeting RNA that are involved in human disease. Read more about Yaping in this week's RNA Featured Researcher.
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The U-M Office of Faculty Affairs oversees the election of several committees.
Congratulations to RNA Center co-director, Mats Ljungman, who was recently elected to serve in the important role of Advisory Committee on Appointments, Promotions, and Tenure (ACAPT) – Clinical Departments.
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Consequences of Uridine mRNA Modifications on Translation
Monday, June 13, 2022
10:00 - 11:00 AM
East Conference Room, Rackham
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Mechanisms of Nutrient Sensing and Gene Regulation by the E. Coli Leucine-Responsive Regulatory Protein, a Global Feast-Famine Transcriptional Regulator Christine Ziegler, advisor: Peter Freddolino
Tuesday, June 14, 2022
2:00 - 3:00 PM
North Lecture Hall, Med Sci II
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4D Nucleome-Guided Cellular Reprogramming Gabrielle Dotson, advisor: Indika Rajapakse
Wednesday, June 15, 2022
10:00 - 11:00 AM
West Lecture Hall, Med Sci II
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RNA Collaborative Seminar Series |
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----Wednesday, June 15, 2022
----10:00 - 11:00 AM
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Catalyzing tRNA, mRNA or others? The multifaceted role of tRNA modifying enzymes
Structural insights into substrate targeting and inhibition of CRISPR-Cas systems
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U-M BioInnovations in Brain Cancer (BIBC) Research Seminar |
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Trainee Presentations and Happy Hour
Thursday, June 16, 2022
4:00 - 5:00 PM
Research Auditorium, NCRC 10
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U-M Molecular, Cellular, and Developmental Biology |
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Control of the Anti-viral Response Through Spatial Re-localization of an RNA Phosphatase
Friday, June 17, 2022
12:00 - 1:00 PM
1060 BSB
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Statistical Methods and Computational Tools for High-throughput Genomics Data
Tuesday, June 21, 2022
9:00 - 10:00 AM
M1122, SPH II
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RNA Therapeutics Institute (RTI) |
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4th Annual RNATx Symposium
Virtual event with talks, posters and more..
June 22-24, 2022
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Toronto RNA Enthusiasts' Day (TREnD)
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TREnD will be held online via Zoom/Fourwaves. Poster session & trainee talks on both days.
July 27 – 28, 2022
Toronto, Canada
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Pfizer is seeking proposals for the advancement of therapeutics in renal disorders
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>> DUE TODAY June 13th, 2022 << |
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Catalyzing translational research efforts by supporting preclinical and commercial clinical development |
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Innovation Partnerships at the University of Michigan manages Great Lakes Discovery, a ten-year collaboration with Deerfield Management Company, L.P to fund U-M drug discovery from early-stage research to clinical development.
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Deerfield has committed up to $130 million over the next decade to invest in biomedical research at U-M with the aim of developing potentially life-saving drugs and disease treatments.
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Projects selected by Great Lakes Discovery will be provided funding and operational support through a development plan aimed at achieving Investigational New Drug (IND) readiness.
GET STARTED WITH A CONSULTATION There is no open Request for Proposal (RFP) - the first step for an interested researcher is to schedule a consultation with the program’s Scientific Collaboration Manager Dr. Seohee You (shyou@umich.edu).
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Our members' publications are available through Altmetrics. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation. Below are recent highlights.
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Highlights
- Long noncoding RNAs (lncRNAs) are tissue- and context-specific modulators of immune cell development, differentiation, activation, and function.
- lncRNA molecular mechanisms are diverse and challenging to predict.
- lncRNAs impact on the outcomes of protective and pathogenic immune responses in a variety of diseases.
- lncRNA genes outnumber protein-coding genes, but comparatively few lncRNAs have been functionally or mechanistically characterized.
- Further unlocking the role of lncRNAs in immunity may lead to improved outcomes for diseases that are influenced by protective and pathogenic immune responses.
Despite an ever-increasing appreciation of how protein-coding genes shape immune responses, the molecular underpinnings of immune regulation remain incompletely understood. This incomplete picture impedes the development of more precise therapeutics and diagnostics for immune-mediated diseases. Long noncoding RNAs (lncRNAs) are versatile cell- and context-specific regulators of gene expression and cellular function. The number of lncRNA genes rivals that of protein-coding genes; however, comparatively little is known about their function. Even though the functions of most lncRNA genes are unknown, multiple lncRNAs have recently emerged as important immune regulators. Therefore, further unlocking the role of lncRNAs in the mammalian immune system coupled with their tissue-specific expression might lead to more precise therapeutics and diagnostics for immune disorders in general.
Keywords: long noncoding RNA, immunity, autoimmunity, inflammatory immune disorders, alloimmunity, antitumor immunity
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Tsoi, L.C., Xing, X., Kahlenberg, J. M., Scott, V. E., & Gudjonsson, J. (2022). Noninvasive Tape-Stripping with High-Resolution RNA Profiling Effectively Captures a Preinflammatory State in Nonlesional Psoriatic Skin. Journal of Investigative Dermatology, 142(6), 1587–1596. https://doi.org/10.1016/j.jid.2021.09.038
Tape stripping is a minimally invasive, nonscarring method that can be utilized to assess gene expression in the skin but is infrequently used given technical constraints. By comparing different tape stripping technologies and full-thickness skin biopsy results of lesional and nonlesional psoriatic skin from the same patients, we demonstrate that tape stripping with optimized high-resolution transcriptomic profiling can be used to effectively assess and characterize inflammatory responses in the skin. Upon comparison with single-cell RNA-sequencing data from psoriatic full-thickness skin biopsies, we illustrate that tape-stripping efficiently captures the transcriptome of the upper layers of the epidermis with sufficient resolution to assess the molecular components of the feed-forward immune amplification pathway in psoriasis. Notably, nonlesional psoriatic skin sampled by tape stripping demonstrates activated, proinflammatory changes when compared to healthy control skin, suggesting a prepsoriatic state, which is not captured on full-thickness skin biopsy transcriptome profiling. This work illustrates an approach to assess inflammatory response in the epidermis by combining noninvasive sampling with high throughput RNA-sequencing, providing a foundation for biomarker discoveries and mechanism of action studies for inflammatory skin conditions.
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