The RNA Transcript, May 23, 2022 |
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We are thrilled to announce that Rachel as agreed to join us as a faculty member in Biological Chemistry and the Center for RNA Biomedicine.
Rachel will bring exciting new directions in RNA biology to our community, with a research program focused on defining determinants of mRNA translational output. We are thrilled that she has chosen Michigan. Rachel, her husband Andrew, and their son Connor will be moving from New Haven to Ann Arbor this fall for an anticipated November 1 start.
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About Dr. Niederer:
Dr. Niederer completed her undergraduate degree at the University of Maryland, College Park in Biochemistry and Cell Biology/Molecular Genetics where she worked with Dr. Jon Dinman to study the effect of RNA modifications on translational fidelity. She went on to obtain her Ph.D. from John Hopkins under the mentorship of Dr. David Zappula, where she defined shared structural and functional features in telomerase RNA and explored the transcriptional response to telomere loss and senescence. Dr. Niederer carried out postdoctoral studies first with Dr. Melissa Moore at the University of Massachusetts and then (when Dr. Moore moved to Moderna) with Dr. Wendy Gilbert at Yale studying mechanisms of translational control. Rachel developed a novel method to rapidly and quantitatively measure ribosome recruitment to thousands of 5’-UTR sequences to define features controlling translation initiation. This approach, termed Direct Analysis of Ribosome Targeting (DART), published this spring in Cell Systems, has uncovered hundreds of new, functional RNA elements in yeast that differ in their ability to recruit ribosomes and to act as sequence-specific translational repressors.
Future Scientific Plans:
Dr. Niederer’s laboratory will explore mechanisms of translational control. She will bring a new set of cutting-edge approaches for studying translation initiation to the Department of Biological Chemistry, the Center for RNA Biomedicine, and the broader UM community.
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Regents approve faculty promotions |
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Monica Dus, associate professor of molecular, cellular, and developmental biology, with tenure
Sue Hammoud, associate professor of human genetics, with tenure, associate professor of urology, without tenure, and associate professor of obstetrics and gynecology, without tenure
Jeffrey Kidd, professor of human genetics, with tenure, and professor of computational medicine and bioinformatics, without tenure
Jacob Kitzman, associate professor of human genetics, with tenure, and associate professor of computational medicine and bioinformatics, without tenure
Adam Lauring, professor of internal medicine, with tenure, professor of microbiology and immunology, without tenure, Medical School; and professor of ecology and evolutionary biology, without tenure, LSA
Jun Hee Lee, professor of molecular and integrative physiology, with tenure; and research professor, Institute of Gerontology
Sarah Veatch, professor of biophysics, with tenure, and professor of physics, without tenure
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Kay Beattie retired from the LSA Dean’s Office in 2007, after 40 years of service to the University. This award was established in her honor by former Dean Terry McDonald. Presented to an outstanding employee with more than 3 years of service at the University who has been contributing beyond the ordinary fulfillment of duties and taking on increasing levels of responsibility with a significant portion of their career in LSA. |
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>> TODAY <<
U-M Center for RNA Biomedicine Innovation Seminar
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A miRNA-mediated approach to dissect the complexity of cancer progression and identify anti-cancer drugs
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The Role of piRNA in Environmental Epigenetics
Monday, May 23, 2022
4:00 pm - 5:00 pm
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U-M Oral Dissertation Defense |
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Shared Regulators of Axon Degeneration and Synaptic Structure
advisor: Catherine A Collins
Friday, May 27, 2022
10:00 - 11:00 AM
BSB 550
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27th Annual RNA Society Meeting
May 31 to June 5, 2022
Boulder, Colorado (in-person)
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----Wednesday, June 1, 2022
----10:00 pm - 11:00 am
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SARS-CoV-2 nucleocapsid protein-RNA interactions encode viral functions
Counterbalanced interactions between DNA regulatory elements control long-distance epigenetic silencing by the Airn lncRNA
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U-M Mary H. Weiser Food Allergy Center |
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Advancing the Science of Food Allergy
Offers an outstanding program featuring 15 esteemed biomedical experts and thought leaders in clinical and basic research
June 1-2, 2022
BSRB
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U-M CRYO-EM Summer Workshop |
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I have my data set — Now what?
Participants will be introduced to common image processing packages used to analyze cryo-EM data.
June 5 - 9, 2022
LSI Building
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U-M RNA Innovation Seminar |
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Long non-coding RNAs as evolutionarily fluid chromatin weavers
Monday, June 6, 2022
4:00 pm - 5:00 pm
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U-M RNA Student Postdoc Council event |
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The RNA Function
A networking event designed for U-M students and postdocs from across the university to hear what other groups are doing around campus
Thursday, June 9, 2022
12:00 pm - 3:00 pm
BSRB, ABC Seminar rooms
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Pfizer is seeking proposals for the advancement of therapeutics in renal disorders
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Open for Submissions: April 25th - June 13th, 2022 |
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Catalyzing translational research efforts by supporting preclinical and commercial clinical development |
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Innovation Partnerships at the University of Michigan manages Great Lakes Discovery, a ten-year collaboration with Deerfield Management Company, L.P to fund U-M drug discovery from early-stage research to clinical development.
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Deerfield has committed up to $130 million over the next decade to invest in biomedical research at U-M with the aim of developing potentially life-saving drugs and disease treatments.
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Projects selected by Great Lakes Discovery will be provided funding and operational support through a development plan aimed at achieving Investigational New Drug (IND) readiness.
GET STARTED WITH A CONSULTATION There is no open Request for Proposal (RFP) - the first step for an interested researcher is to schedule a consultation with the program’s Scientific Collaboration Manager Dr. Seohee You (shyou@umich.edu).
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Pfizer is looking for a Senior Scientist
in mRNA Vaccine Development
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We are looking for a Senior Scientist who will work on various aspects of mRNA production for the Upstream Development Group within Early Bioprocess Development at VRD in Pearl River, NY. The incumbent will work on current generation mRNA production, but also innovate, develop and optimize methods to further the state of the art in generating high quality mRNA. This development work will be pursued in the context of producing RNA both at lab scale and upwards. A strong, hands-on background in mRNA generation is required, including in vitro transcription, as well as in general molecular biology and biochemistry. There would be special interest in candidates with a strong biochemical, biophysical, and/or structural biology background in the context of mRNA. The incumbent would be joining a team of scientists well-versed in mRNA production, and would both lead and support efforts with the team. Apply here
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Our members' publications are available through Altmetrics. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation. Below are recent highlights.
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Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP, S. W. Olson, A. W. Turner, J. W. Arney, I. Saleem, C. A. Weidmann, D. M. Margolis, K. M. Weeks, A. M. Mustoe, (2022) Molecular Cell. 10.1016/j.molcel.2022.02.009
Highlights
- DANCE-MaP enables complete characterization of RNA structural ensembles in cells
- The 7SK RNA encodes a large-scale structural switch that modulates P-TEFb binding
- 7SK structure switches dynamically in response to cell growth and stress
- The 7SK switch is a potential therapeutic target for modulating transcription
Keywords: DANCE-MaP; ensemble deconvolution; noncoding RNA; transcriptional regulation; cancer; HIV
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