The RNA Transcript, May 9, 2022 |
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Jay Querido, University of Michigan RNA Faculty this Fall!
We are thrilled to announce that Jay as agreed to join us as a faculty member in Biological Chemistry, the Center for RNA Biomedicine, and the LSI.
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About Dr. Brito Querido:
A native of Cape Verde, Dr. Querido received undergraduate and M.S. degrees at the University of Lisbon. For his Ph.D., Dr. Querido worked with Dr. Yaser Hashem in Strasbourg, France using cryo-EM to study parasite-specific ribosomal proteins. Dr. Querido then moved to Dr. Venki Ramakrishnan’s lab at the MRC Laboratory of Molecular Biology for post-doctoral work, where he has tackled longstanding questions surrounding translation initiation on eukaryotic mRNAs. Most prominently, Dr. Querido determined the structure of a 48S translation initiation complex and suggested a novel mechanism for ribosome recruitment and mRNA scanning (Brito Querido et al., Science 2020).
Future Scientific Plans:
Currently, Dr. Querido is exploring translation initiation on structured mRNAs and the role of the human tumor suppressor protein Pdcd4 in regulating translation. Dr. Querido has exciting plans to continue in this field, with a goal of understanding the many ways in which RNA helicases regulate gene expression in health and disease.
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The objective of the RNA council is to work collaboratively across disciplines, build a scientific community, and generate ideas and activities that advance RNA research and education across U-M. The RNA Council is sponsored by The RNA Society. |
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>> Next event: The RNA Function
Thursday, June 9, 2022
12:00-3:00 PM
BSRB, ABC Seminar rooms
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Agenda
12:00 -1:30 Lunch and poster sessions
1:30 - 1:45 Break
1:45 - 3:00 Scientific-Speed-Networking
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U-M RNA Innovation Seminar |
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Unexpected determinants of neuronal identity and properties: the curious cases of PTBP1, PTBP2, and neuronal splicing
TODAY Monday, May 9, 2022
4:00 pm - 5:00 pm
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U-M Variations In Biology Seminar Series |
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Genetics of spectacular diversity in the rock pigeon
Tuesday, May 10, 2022
4:00 pm - 5:00 pm
co-hosted by COPD, MCDB, and EEB
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Non-coding RNA Journal Webinar Series |
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Unexpected Noncoding Roles of RNA in the Regulation of Cancer
Tuesday, May 10, 2022
4:00 pm - 5:00 pm
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U-M Oral Dissertation Defense |
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Associative Learning Circuits Regulate Meal Size Through Dopamine Plasticity
advisor: Monica Dus
Wednesday, May 11, 2022
12:30 - 1:30 PM
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Viral Pathogens: Us vs. Them
Friday, May 13, 2022
8:45 am - 4:10 pm
Kahn Auditorium, BSRB
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U-M Oral Dissertation Defense |
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mRNA Modifications Modulates Translation Rate and Fidelity
advisors: Kristin Koutmou and Kaushik Ragunathan
Monday, May 16, 2022
9:00 - 10:00 AM
Chemistry 1640
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U-M RNA Innovation Seminar |
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An Academic Approach to Oligonucleotide Therapeutics
Monday, May 16, 2022
4:00 pm - 5:00 pm
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----Wednesday, May 18, 2022
----10:00 pm - 11:00 am
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TRMT112, a master regulator of RNA methyltransferases modifying factors involved in mRNA translation
Fluorescent nanoparticles for amplified detection and imaging of RNA in solution and cells
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U-M Department of Molecular, Cellular and Developmental Biology |
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The Regulation of Signal Transduction by Phase Separated Biomolecular Condensates
Friday, May 20, 2022
12:00 pm - 1:00 pm
1060 BSB
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Pfizer is seeking proposals for the advancement of therapeutics in renal disorders
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Open for Submissions: April 25th - June 13th, 2022 |
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Catalyzing translational research efforts by supporting preclinical and commercial clinical development |
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Innovation Partnerships at the University of Michigan manages Great Lakes Discovery, a ten-year collaboration with Deerfield Management Company, L.P to fund U-M drug discovery from early-stage research to clinical development.
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Deerfield has committed up to $130 million over the next decade to invest in biomedical research at U-M with the aim of developing potentially life-saving drugs and disease treatments.
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Projects selected by Great Lakes Discovery will be provided funding and operational support through a development plan aimed at achieving Investigational New Drug (IND) readiness.
GET STARTED WITH A CONSULTATION There is no open Request for Proposal (RFP) - the first step for an interested researcher is to schedule a consultation with the program’s Scientific Collaboration Manager Dr. Seohee You (shyou@umich.edu).
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Our members' publications are available through Altmetrics. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation. Below are recent highlights.
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Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP, S. W. Olson, A. W. Turner, J. W. Arney, I. Saleem, C. A. Weidmann, D. M. Margolis, K. M. Weeks, A. M. Mustoe, (2022) Molecular Cell. 10.1016/j.molcel.2022.02.009
Highlights
- DANCE-MaP enables complete characterization of RNA structural ensembles in cells
- The 7SK RNA encodes a large-scale structural switch that modulates P-TEFb binding
- 7SK structure switches dynamically in response to cell growth and stress
- The 7SK switch is a potential therapeutic target for modulating transcription
Keywords: DANCE-MaP; ensemble deconvolution; noncoding RNA; transcriptional regulation; cancer; HIV
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