Efficient in situ Screening of and Data Collection from Microcrystals in Crystallization Plates | |
Image Source: Thompson, A. J., Sanchez-Weatherby, J., Williams, L. J., Mikolajek, H., Sandy, J., Worrall, J. A. R. & Hough, M. A. (2024). Acta Cryst. D80, 279-288.. | |
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In a paper at Acta Crystallographica Section D, Michael A. Hough et al. discuss improving the efficiency of analyzing microcrystals used in crystallography experiments at advanced light sources (XFELs and synchrotrons). The authors introduce a new method where microcrystals are analyzed directly within standard crystallization plates using a raster scanning technique. This method is very sample-efficient, meaning it requires minimal amounts of crystal material, and it saves time compared to traditional methods. The results from this in-plate analysis were comparable to other crystallography techniques. The authors conclude that this technique is valuable for early-stage structural analysis, allowing scientists to optimize their microcrystal production and make better use of valuable beamtime at XFEL facilities.
Our MiTeGen In Situ-1 Crystallography Plates were used as part of this research.
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Have You Tried Our Loops Yet? | | |
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If you are using another brand of loops for your crystallography research, we encourage you to try our loops. Researchers trust our loops, which have been mentioned in over 2,500 research publications.
To start with, visit our loop selection guide. Then, visit our loop department to choose the loop appropriate for your research. We also offer a loop sampler kit that can be customized to your needs.
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Do you need help in selecting the correct loops for your research? Then, please contact us and request a consultation on choosing the appropriate loops for your research. | |
Pacific Northwest Summer Crystallographic Institute | | |
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The Pacific Northwest Summer Crystallographic Institute is a four-day program designed to teach students and faculty about X-ray crystallography, which is used to understand small molecules.
Unlike other programs that train professional crystallographers, this institute focuses on helping researchers better utilize crystallographic data in their work. Registration is still open for this program. MiTeGen is sponsoring the program.
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Cryo-EM Storage and Shipping Systems | | |
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Our MiTeGen Cryo-EM Grid Storage and Shipping Systems offer specialized solutions for organizing, storing, tracking, and shipping samples prepared for Cryogenic Electron Microscopy (Cryo-EM).
Various pre-configured systems cater to labs of different sizes and Cryo-EM usage levels. For labs with unique requirements, custom systems can be designed to provide the perfect storage and shipping solution.
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HWI Crystallization Workshop | |
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The Hauptman-Woodward Medical Research Institute is running a crystallization workshop focused on the practical aspects of setting up optimization trays for diffraction-based experiments. The workshop will include tutorials on designing grid screens using multiple crystallization formats and crystal harvesting. Participants will be encouraged to set up experiments to optimize crystals of their own proteins of interest using cutting-edge crystallization equipment and crystal imagers equipped with SONICC.
The workshop is open to researchers at all levels, including students, postdocs, and PIs. It is segmented into a 4 to 5-hour virtual component on May 23rd and two on-site in-person components in Buffalo, New York, on June 20-21, 2024, or August 20-21, 2024. We are sponsoring this workshop.
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The 9th Annual Hitchhiker's Guide to the Biomolecular Galaxy is May 23rd to 24th at Purdue University. The meeting highlights cutting-edge biophysical research that graduate students, postdocs, and faculty are doing at universities around the Midwest. The event features round-table discussions, faculty-led workshops, and networking events. We are a sponsor of this event. | |  |
The EMBO practical course in time-resolved macromolecular serial crystallography is July 8th to 12th in Grenoble, France. This course will train researchers in sample preparation, crystal delivery methods & data collection and analysis of the electron density map differences used at 4th generation synchrotron serial crystallography beamlines. We are a sponsor of this event. | | |
Events, Workshops and Conferences | | |
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If you are looking for more events, please visit our events page. It lists conferences, workshops, symposiums, user meetings, and more.
Topics include structural biology, material science, crystallography, cryo-EM, beamline research, and more.
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Industry Resources and News | |
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Here is a small selection of industry resources and news for your browsing.
- Paper at Acta Cryst A, The single-atom R1: a new optimization method to solve crystal structures - Learn More
- From the Blog at the CCDC, Remembering Professor Arnold Rheingold - Learn More
- Research article from Wiley Online, Structural dynamics and functional cooperativity of human NQO1 by ambient temperature serial crystallography and simulations - Learn More
- CASP16 call for targets is now open, submit your targets to Critical Assessment of protein Structure Prediction, including structures determined by multiple experimental methods (cryoEM, NMR, X-ray crystallography, SAXS, cross-link) - Learn More
- From the CCDC Blog, CSD in Action: Knowledge-based Cocrystal Design - Learn More
- News from the University of Canterbury, Out of this world: NZ research to fly on ISS for first time - Learn More
- From Oxford University Press, Structure of native four-repeat satellite III sequence with non-canonical base interactions - Learn More
- Commentary at IUCrJ, A new approach for serial electron diffraction data collection - Learn More
- Cambridge University Press call for papers on the Perspectives in Integrated Biophysics - Learn More
- Research Paper at IUCrJ, Dynamical refinement with multipolar electron scattering factors - Learn More
- From the CCDC, outreach activities for exploring the wonders of crystals - Learn More
- Laboratory notes at Appl Cryst JAC, From solution to structure: empowering inclusive cryo-EM with a pre-characterization pipeline for biological samples - Learn More
- Article at Nature Communications, High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design - Learn More
- Research Paper at Acta Cryst D, Tomo Live: an on-the-fly reconstruction pipeline to judge data quality for cryo-electron tomography workflows - Learn More
- Article at Nature, Time-resolved cryo-EM of G-protein activation by a GPCR - Learn More
- Preprint at bioRxiv, Towards Interpretable Cryo-EM: Disentangling Latent Spaces of Molecular Conformations - Learn More
- Paper at Acta Cryst D, From femtoseconds to minutes: time-resolved macromolecular crystallography at XFELs and synchrotrons - Learn More
- The Advanced Photon Source upgrade project in pictures - Learn More
- From ESRF Tech Talk, A new integrated beamline control system called BLISS, now available on 75% of ESRF beamlines. BLISS offers many advantages that allow users to take full advantage of the new capabilities of the EBS - Learn More
- Find beamline proposal deadlines from around the world at Lightsources.org - Learn More
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