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March 11, 2024

Announcements

Giving Blue Day - Wednesday, March 13 - Save the Date

Please join U-M on March 13, 2024 for Giving Blueday, our annual day of giving. We all have something to give. Join in. Make a difference!


Your donation to the Center for RNA Biomedicine will help us develop therapies to treat even the rarest diseases for which no medicines are currently available.


Visit our Giving Blue Day page to read the story, and help turn the dream into reality for so many.

Upcoming Seminars

RNA Innovation Seminar Series | Monday, March 18, 4:00 p.m. - 5:00 p.m.

RNA Innovation Seminar Series


"Transcription-driven DNA repair"


Evgeny Nudler, Ph.D.

Julie Wilson Anderson Professor of Biochemistry

Department of Biochemistry & Molecular Pharmacology

New York University


Monday - March 18, 4:00 p.m. - 5:00 p.m. ET

BSRB ABC Seminar Rooms, Hybrid Link

Affiliated Seminars

HMS Initiative for RNA Medicine Seminar Series

Willeke van Roon-Mom, Ph.D.Professor Translational Slides of Neurodegenerative Disorders

Department of Human Genetics

Leiden University Medical Center

The Netherlands


"RNA targeting therapy for neurological disorders: From treating many to treating one"

 

Tuesday, March 12, 2024 | 3:00 – 4:00 PM EST

Virtual Seminar 

To Join Click this link: https://qrco.de/beqfUn   

 

For questions reach out to Grace Lee at glee8@bidmc.harvard.edu

You can view all recorded seminars on the HIRM video gallery

RNA Collaborative Seminar Series

UMass Chan Medical School, RNA Therapeutics Institute


Speaker Andrei Korostelev, Ph.D., "Tracking assembly and function of single active RNPs in real-time"


Speaker Julia Alterman, Ph., D., "Delivering siRNA to the skin: an investigation of novel chemistry and routes of administration"


Moderator:  Jonathan Watts, Ph.D.Associate Professor, RNA Therapeutics Institute and Department of Biochemistry & Molecular Pharmacology, UMass Chan Medical School, Worcester, MA, USA



Wednesday, March 13, 2024, 10 AM ET

Zoom Registration

RNA Society

From our sponsor: Lexogen RNA Expertise Blog Series

New Blog Post! February 28, 2024: Introducing High-Definition Single-cell RNA-Seq.


Single-cell RNA-Seq has revolutionized the field of transcriptomics, providing unprecedented insight into cellular complexity and heterogeneity. In our first blog post of the RNAEXPERTise Blog Series on Single-Cell RNA-Seq – “Classical Single-Cell RNA Sequencing: a comprehensive overview” we talked about the basic principles, benefits, and most common applications of classical single-cell RNA-Seq.

In the News

Stephen Parker, Ph.D, establishes new Epigenomic Metabolic Medicine Center (EM2C)

Congratulations to Dr. Stephen Parker, Associate Professor of Computational Medicine and Bioinformatics, Human Genetics, and Biostatistics on the formation of the Epigenomic Metabolic Medicine Center (EM2C) at the U-M Medical School. The new Center aims to perform population-scale single-cell multi-omics profiling with the goal of better understanding how genetic variations contribute to common, complex diseases, such as diabetes and related traits. Once new genetic mechanisms are identified, researchers can use this information to develop better strategies to detect, treat, and prevent these diseases.

 

READ about EM2C

Maria Castro and Pedro Lowenstein project selected for STAT Madness Tournament of Science

BioInnovations in Brain Cancer Program


Fellow Biosciences Initiative center, BioInnovations in Brain Cancer, announced on March 4 that the BIBC project, a phase 1 first in human Clinical trial, led by Dr. Pedro Lowenstein and Dr. Maria G. Castro, has been selected as one of the four UofM entries for the STAT Madness tournament of science.


Maria Castro, Ph.D., and Pedro Lowenstein, M.D., Ph.D., are Faculty Members of the Center for RNA Biomedicine.


Please take a few minutes to vote for the BIBC project by clicking on the U-M Rogel Cancer Center project.


Congratulations Maria and Pedro!

In Case You Missed It ...

Faculty Scholar Jay Brito Querido, Ph.D., publishes new review article focusing on the RNA translation initiation process

In the review, Jay Brito Querido, Ph.D., and colleagues Irene Díaz-López, Ph.D., and Vinki Ramakrishnan, Ph.D., from Cambridge University, United Kingdom, discuss the current state of knowledge on eukaryotic translation initiation. They focus specifically on recent advances in understanding the processes involved in assembling the pre-initiation complex, and ribosome scanning along the 5′ untranslated region of mRNA. Congratulations Jay!


"The molecular basis of translation initiation and its regulation in eukaryotes"


Review Article | 05 December 2023 Nature Reviews Molecular Cell Biology 25 | doi:10.1038/s41580-023-00624-9

Oral Defenses

U-M Oral Dissertations

"Diagnostic and Prognostic Profiling of Infectious Diseases Through Multiplexed Protein Assays"


Krista Meserve, Chemistry

Advisor: Ryan Castle Bailey


Thursday, March 14, 2024

11:00 AM

WEISER HALL, 5TH FLOOR SEMINAR ROOM

"Interrogating Stem Cell Niche Factors in the Developing Human Gut to Advance in Vitro Models"


Charlie Childs, Cell & Developmental Biology

Advisor: Benjamin Allen


Friday, March 15, 2024

2:20 PM

MED SCI II 3699 SOUTH LECTURE

"Substrate Recognition and Specificity of a Minimal Protein-Only RNase P"


Catherine Wilhelm, Chemistry

Advisor: Markos Koutmos


Friday, March 15, 2024

3:00 PM

CHEM 1706

For more information and to view the full schedule of upcoming U-M Oral Defenses, please visit the Rackham Graduate School Oral Defenses website.

Upcoming Meetings

HIRM 2024 Symposium, April 25, 2024 - Registration Open!

2024 Symposium

 

HIRM 10 Year Anniversary Symposium

Thursday, April 25, 2024

 

Joseph B. Martin Conference Center

77 Avenue Louis Pasteur

Boston, MA 02115


Registration & Poster Session is Open


If you wish to submit a poster please reach out to glee8@bidmc.harvard.edu to get a submission form.


Deadline for Poster Submissions is Friday, March 1 at 5 PM EST.

RNA Society Annual Meeting May 28 - June 2, 2024

RNA Society Annual Meeting 2024

 

May 28 - June 2, 2024

Edinburgh, Scotland


Organizers:

David Tollervey (Edinburgh)

Atlanta Cook (Edinburgh)

Ben Blencowe (Canada)

Markus Bohnsack (Germany)

Yue Wan (Singapore)


Registration is Open


Participants who wish to submit an abstract must first register to attend the meeting. Immediately after completing registration, you will receive a confirmation email with a link to submit your abstract. More information can be found on the registration page.


Present Registration Deadlines:


Oral abstract submitters – March 4, 2024

Poster-only abstract submitters – April 1, 2024


Any questions email RNA2024@RNASociety.org

6th Annual RNATx Umass June 26-28, 2024

2024 RNATx Registration IS NOW OPEN!

From Concept to Clinic happening both in person and virtually, at the RNA Therapeutics Institute at UMass Chan Medical School

 

June 26 - June 28, 2024


We invite you to share your work with leading RNA Investigators by submitting your abstracts. We will be evaluating abstracts for a limited number of short talks, so submit yours early!


Oral Abstract Submission Deadline: March 8, 2024

Poster Abstract Submission Deadline: March 22, 2024

Early Registration Deadline: April 19, 2024


See abstract guidelines and tips for proper formatting and how to write your abstract.


Please see our symposium website for details and do not hesitate to contact us if you have any questions at RNATherapeutics@umassmed.edu. 

RiboClub 25th / RiboWest 20th / TREnD 8th Anniversary Celebration in Ottawa: RNA Canada 2024: The future of RNA technology

RiboClub 25th / RiboWest 20th / TREnD 8th Anniversary Celebration, taking place in Ottawa from September 30 to October 4, 2024

 

This milestone event promises to be extraordinary, with over 100 speakers, at least half of whom will be selected from submitted abstracts, ensuring a diverse and inclusive representation of leaders in the field.

 

As we celebrate 25 years of friendship, collaboration, and networking, This gathering marks the inauguration of RNA Canada, a new initiative aimed at strengthening the bonds between the international RNA community and our Canadian colleagues.


Download the complete program.

NEW! Non-coding RNA World 2024: Exploring Mechanisms, Designing Medicines | October 7-9, 2024

Join us in Basel in October to learn about the latest developments in Non-Coding RNA research. Mingle with the world-leading invited speakers during ample networking opportunities. Present your research at poster sessions and numerous selected oral presentations. Discover the beautiful mediaeval city of Basel.

 

More details and abstract submission here: https://sciforum.net/event/ncRNA2024

Our members' publications are available through Altmetric. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation.


Below are recent highlights.

Taylor AS, Mannan R, Pantanowitz L, Chinnaiyan AM, Dhanasekaran SM, Hrycaj S, Cao X, Chan MP, Lucas D, Wang XM, Mehra R. Evaluation of TRIM63 RNA in situ hybridization (RNA-ISH) as a potential biomarker for alveolar soft-part sarcoma (ASPS). Med Oncol. 2024 Feb 23;41(3):76. doi: 10.1007/s12032-024-02305-9. PMID: 38393424; PMCID: PMC10891236.

Emery T. Usher, Rishav Mitra, James C. Bardwell, Alex S. Holehouse, Computational study of RNA binding by a short intrinsically disordered protein, Biophysical Journal, VOLUME 123, ISSUE 3, SUPPLEMENT 1, 216A, FEBRUARY 08, 2024, DOI:https://doi.org/10.1016/j.bpj.2023.11.1370

Feldstein LR, Britton A, Grant L, Wiegand R, Ruffin J, Babu TM, Briggs Hagen M, Burgess JL, Caban-Martinez AJ, Chu HY, Ellingson KD, Englund JA, Hegmann KT, Jeddy Z, Lauring AS, Lutrick K, Martin ET, Mathenge C, Meece J, Midgley CM, Monto AS, Newes-Adeyi G, Odame-Bamfo L, Olsho LEW, Phillips AL, Rai RP, Saydah S, Smith N, Steinhardt L, Tyner H, Vandermeer M, Vaughan M, Yoon SK, Gaglani M, Naleway AL. Effectiveness of Bivalent mRNA COVID-19 Vaccines in Preventing SARS-CoV-2 Infection in Children and Adolescents Aged 5 to 17 Years. JAMA. 2024 Feb 6;331(5):408-416. doi: 10.1001/jama.2023.27022. PMID: 38319331; PMCID: PMC10848053.

Yang S, Zhou X. SRT-Server: powering the analysis of spatial transcriptomic data. Genome Med. 2024 Jan 26;16(1):18. doi: 10.1186/s13073-024-01288-6. PMID: 38279156; PMCID: PMC10811909.

Job Postings

Ohio Eminent Scholar in Molecular Genetics


The Department of Molecular Genetics in the College of Arts and Sciences at The Ohio State University invites applications for the position of Ohio Eminent Scholar in Molecular Genetics, an endowed, tenure-track position at the Associate or Full Professor level. The Ohio Eminent Scholars (OES) Program, created by the Ohio General Assembly and administered by the Ohio Board of Regents, aims to enhance the national eminence of selected outstanding academic programs at Ohio universities by attracting internationally recognized scholars. Applications are sought from those with a distinguished track record of investigating fundamental biological questions in any system.  

University of Michigan BIBC Tenure Track Faculty Search - Deadline: Mar 31, 2024 at 11:59 PM EDT


The University of Michigan has launched a Tenure Track Faculty Search for the BioInnovations in Brain Cancer Initiative (BIBC), led by Center for RNA Biomedicine Faculty Member Dr. Maria G. Castro and Dr. Steven Schwendeman. Learn more.

The University of California Irvine (UCI), Department of Ophthalmology Full-Time Position


Inviting applicants focused on the development of genetic engineering and genome editing technologies. Learn more.

Postdoctoral Research Fellow and Graduate Research Assistants

Dr. Guizhi (Julian) Zhu Lab | University of Michigan


Multiple full-time openings for Postdoctoral Research Fellow and Graduate Research Assistants. Learn more.

Recruitment Opportunities

For complete details on current openings and how to apply for these positions, visit the Recruitment Opportunities page on our website

To share your news and comments, please contact

rna-communications@umich.edu

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