Registration closes Friday -- secure your spot now! | |
Keynote Speaker - Peter Todd, Ph.D. | | |
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8th Annual Symposium Speaker
"Short Tandem Repeats in Neuronal Function and Neurological Disease"
Peter Todd, M.D., Ph.D.+
Chester and Anne Alecks Sackett Endowed Professor, Professor of Neurology, Associate Chair for Research, Department of Neurology, Medical Director, Neurology and Professor of Human Genetics, Medical School
Abstract: There are over 3 million Short Tandem Repeats in the human genome. Expansions in a small subset (~50) of these repeats are currently linked to human neurological diseases such as Autism, ALS, and FTD, although recent findings suggest more disease-causing repeats await discovery. Our group studies the mechanisms by which repeat expansions cause disease, with a specific focus on toxic RNA gain-of-function mechanisms and the unconventional translation of repeats in the absence of an AUG start codon (“RAN translation”). In this presentation, I will discuss recent data on the mechanisms by which RAN translation occurs and its role in disease pathogenesis in Fragile X-associated disorders. I will also discuss how repeats have important native functions in neurobiology. Our thesis is that emerging disease mechanisms can inform a broader understanding of the native roles of short tandem repeats in neuronal function and that aberrations in these native processes provide clues to novel therapeutic strategies for these currently untreatable disorders.
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Mats Ljungman, Ph.D., awarded watershed $3.7 million grant from NIH for KLIPP cancer therapy study | | |
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We are thrilled to announce that Mats Ljungman, Ph.D., Co-Director of the Center for RNA Biomedicine at the University of Michigan, has just been awarded a $3.7 million grant from the National Institutes of Health (NIH) for the purpose of continuing his groundbreaking work with precision-targeting KLIPP cancer therapy – the project’s highest funding by far to date.
Read more
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Peter Todd to be inaugurated as first Chester and Anne Alecks Sackett Endowed Professor on Monday, March 4, 2024 | |
Peter Todd, M.D., Ph.D., Clinical Director, M-RNA Therapeutics | |
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The community is invited to the inauguration and installation of Peter Todd, M.D., Ph.D., as the first Chester and Anne Alecks Sackett Endowed Professor
Monday, March 4, 2024
5:00 PM Ceremony (live stream available)
D. Dan and Betty Kahn Auditorium
Reception to follow
Please RSVP by February 26
For additional information, please contact Dawn Bednarski at 734‑645‑0705 or dbedski@umich.edu.
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Michelle Hastings to be named first Pfizer Upjohn Research Professor on Tuesday, March 5, 2024 | |
Michelle Hastings, Ph.D., Director, M-RNA Therapeutics | |
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The community is invited to the inauguration and installation of Michelle Hastings, Ph.D., as the first Pfizer Upjohn Research Professor of Pharmacology
Tuesday, March 5, 2024
5:00 PM Ceremony (live stream available)
D. Dan and Betty Kahn Auditorium
Reception to follow
Please RSVP by February 27
For additional information, please contact Karen Fox at karfox@umich.edu
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Upcoming Affiliated Seminars | | |
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For more information and to view the full schedule of upcoming U-M Oral Defenses, please visit the Rackham Graduate School Oral Defenses website. | |
From our sponsor: Lexogen RNA Expertise Blog Series | | |
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The 8th annual symposium will take place on Friday, March 8, 8:30 a.m. - 5:00 p.m. in the A. Alfred Taubman Biomedical Science Research Bldg., Kahn Auditorium at 109 Zina Pitcher Place in Ann Arbor, Michigan. Speakers include:
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Drew Weissman, M.D., Ph.D., University of Pennsylvania, 2023 Nobel laureate for Physiology or Medicine for his work on mRNA vaccines
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Victoria D'Souza, Ph.D., Harvard University
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Brenton R. Graveley, Ph.D., University of Connecticut
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Leemor Joshua-Tor, Ph.D., Cold Spring Harbor Laboratory
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Peter Todd, M.D., Ph.D., University of Michigan
Full Symposium Program Now Available
REGISTER TODAY
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HIRM 2024 Symposium, April 25, 2024 - Registration Open! | | |
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2024 Symposium
HIRM 10 Year Anniversary Symposium
Thursday, April 25, 2024
Joseph B. Martin Conference Center
77 Avenue Louis Pasteur
Boston, MA 02115
Registration & Poster Session is Open
If you wish to submit a poster please reach out to glee8@bidmc.harvard.edu to get a submission form.
Deadline for Poster Submissions is Monday, February 19 at 5 PM EST.
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RNA Society Annual Meeting May 28 - June 2, 2024 | |
6th Annual RNATx Umass June 26-28, 2024 | | |
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2024 RNATx Registration IS NOW OPEN!
From Concept to Clinic happening both in person and virtually, at the RNA Therapeutics Institute at UMass Chan Medical School
June 26 - June 28, 2024
We invite you to share your work with leading RNA Investigators by submitting your abstracts. We will be evaluating abstracts for a limited number of short talks, so submit yours early!
Oral Abstract Submission Deadline: March 8, 2024
Poster Abstract Submission Deadline: March 22, 2024
Early Registration Deadline: April 19, 2024
See abstract guidelines and tips for proper formatting and how to write your abstract.
Please see our symposium website for details and do not hesitate to contact us if you have any questions at RNATherapeutics@umassmed.edu.
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Exciting News! RiboClub 25th / RiboWest 20th / TREnD 8th Anniversary Celebration in Ottawa: RNA Canada 2024: The future of RNA technology | | |
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Our members' publications are available through Altmetric. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation.
Below are recent highlights. Bold denotes CRB member.
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Chauvier A, Walter NG. Regulation of bacterial gene expression by non-coding RNA: It is all about time! Cell Chem Biol. 2024 Jan 18;31(1):71-85. doi: 10.1016/j.chembiol.2023.12.011. Epub 2024 Jan 10. PMID: 38211587.https://doi.org/10.1016/j.chembiol.2023.12.011 | |
Wilhelm CA, Mallik L, Kelly AL, Brotzman S, Mendoza J, Anders AG, Leskaj S, Castillo C, Ruotolo BT, Cianfrocco MA, Koutmos M. Bacterial RNA-free RNase P: structural and functional characterization of multiple oligomeric forms of a minimal protein-only ribonuclease P. J Biol Chem. 2023 Oct 6:105327. doi: 10.1016/j.jbc.2023.105327. Epub ahead of print. PMID: 37806495. https://doi.org/10.1016/j.jbc.2023.105327 | |
Brase, L., Dunn, A.R., Morris, J.C., Perrin, R.J., Dumitrescu, L., Kaczorowski, C.C., Hohman, T.J., Karch, C.M., Harari, O. and Benitez, B.A. (2023), Leveraging systems biology approaches and single-nucleus RNA-seq to study sex differences in AD. Alzheimer's Dement., 19: e076877. https://doi.org/10.1002/alz.076877 | |
Kharytonchyk S, Burnett C, Gc K, Telesnitsky A. Transcription start site heterogeneity and its role in RNA fate determination distinguish HIV-1 from other retroviruses and are mediated by core promoter elements. J Virol. 2023 Sep 28;97(9):e0081823. doi: 10.1128/jvi.00818-23. Epub 2023 Sep 8. PMID: 37681957; PMCID: PMC10537674. https://doi.org/10.1093/nar/gkad866 | |
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The Department of Molecular Genetics in the College of Arts and Sciences at The Ohio State University invites applications for the position of Ohio Eminent Scholar in Molecular Genetics, an endowed, tenure-track position at the Associate or Full Professor level. The Ohio Eminent Scholars (OES) Program, created by the Ohio General Assembly and administered by the Ohio Board of Regents, aims to enhance the national eminence of selected outstanding academic programs at Ohio universities by attracting internationally recognized scholars. Applications are sought from those with a distinguished track record of investigating fundamental biological questions in any system.
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University of Michigan BIBC Tenure Track Faculty Search
The University of Michigan has launched a Tenure Track Faculty Search for the BioInnovations in Brain Cancer Initiative (BIBC), led by Center for RNA Biomedicine Faculty Member Dr. Maria G. Castro and Dr. Steven Schwendeman. Learn more.
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The University of California Irvine (UCI), Department of Ophthalmology
Full-Time Position
Inviting applicants focused on the development of genetic engineering and genome editing technologies. Learn more.
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Postdoctoral Research Fellow and Graduate Research Assistants
Dr. Guizhi (Julian) Zhu Lab | University of Michigan
Multiple full-time openings for Postdoctoral Research Fellow and Graduate Research Assistants. Learn more.
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Research Technician and Post-Doctoral Research Fellow | Fred Hutchinson Cancer Center | The Lapointe Lab
Seeking to fill two positions: Research Technician and Post-Doctoral Research Fellow. Learn more.
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Research Technician - Yadavalli Lab
Seeking full-time technician or research scientist to perform cutting-edge research in RNA biology using high-throughput sequencing methods. Learn more.
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Postdoctoral Position - Maquat Lab
A postdoctoral position is open. Applicants should hold a PhD or MD/PhD degree(s) and have expertise in molecular, cellular, or structural biology. Learn more.
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Postdoctoral Position - Cooperman Laboratory
Seeking postdoctoral student with a strong interest in understanding the mechanism and regulation of cytoplasmic eukaryotic protein synthesis. Learn more.
| | For complete details on current openings and how to apply for these positions, visit the Recruitment Opportunities page on our website | | | | |
