The RNA Transcript, January 3, 2022 |
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Mark your calendars for our Speaker Line-up!
Our seminars will feature:
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Monday, January 10, 4 pm
Yale School of Medicine
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Monday, January 31, 4 pm
University of Cambridge
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Monday, February 14, 4 pm
Johns Hopkins University
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Monday, March 7, 4 pm
Langebio, Cinvestav
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Monday, March 28, 4 pm
Yale School of Medicine
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Monday, April 11, 4 pm
Harvard Medical School
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Monday, April 18, 12pm
Duke University
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Monday, May 9, 4pm
UC Riverside
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Our keynote speakers include:
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Massachusetts
Institute of
Technology
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Rosalind Franklin
University of Medicine and
Science
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National Institute
of Child Health and Human
Development
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University of
Colorado-Boulder
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Our Symposium brings together leaders of the scientific, medical and engineering communities working on recent advances of our understanding of RNA. It provides a means of exchanging new ideas across disciplines, spurring new collaborations, and supporting our rapidly growing RNA community. |
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6th Annual Microbial RNA Meeting "Regulating with RNA in Bacteria and Archaea"
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----Monday - Friday
----January 3 - 7, 2022
----Update: program will be online
----#MicrobialRNAs @MeetingRNA
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University of Michigan, Center for RNA Biomedicine, RNA Faculty Candidate Seminar |
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"Uncovering novel translational control elements within 5′ UTRs"
Postdoctoral Researcher
Yale School of Medicine
Monday, January 10, 2022
4:00 pm - 5:00 pm
BSRB, ABC Seminar Rooms (Hybrid)
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Co-hosted with the Department of Biological Chemistry and Department of Human Genetics |
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----Wednesday, January 12, 2022
----4:00 pm - 5:00 pm
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"Human spliceosomal snRNA sequence variants generate variant spliceosomes"
----Biology
"Characterization of RNA binding protein regulation in neural stem cell quiescence exit"
----Bo Peng, Cellular & Molecular Biology
"Unraveling the multiple key roles of a single RBP in development"
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University of Michigan, Chemistry-Biology Interface (CBI) Program Symposium |
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----February 17 - 18, 2022
The Chemistry-Biology Interface (CBI) Training Program is funded by the National institutes of Health (NIH). The symposium will feature a range of faculty and graduate student speakers and poster sessions focusing on research at the interface of chemistry and biology. The symposium offers a forum for trainees around the University to present their original research and engage in stimulating scientific discussion.
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Our members' publications are available through Altmetric. Sept queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation. Please make sure to have at least one of these keywords in your title. Below are recent highlights.
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Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures
M. Zafferani, C. Haddad , Le Luo , J. Davila-Calderon, Liang-Yuan Chiu, C. Shema Mugisha, A. Monaghanan, D. Kennedy, J. Yesselman, R. Gifford, A. Tai, S. Kutluay, Mei-Ling Li, G. Brewer, B. Tolbert and A. E. Hargrove, Science Advances, 26 Nov 2021, Vol 7, Issue 48, DOI: 10.1126/sciadv.abl6096
Abstract: ... Here, we report on the identification of amiloride-based small molecules that potently inhibit OC43 and SARS-CoV-2 replication through targeting of conserved structured elements within the viral 5′-end. Nuclear magnetic resonance–based structural studies revealed specific amiloride interactions with stem loops containing bulge like structures and were predicted to be strongly bound by the lead amilorides in retrospective docking studies. Amilorides represent the first antiviral small molecules that target RNA structures within the 5′ untranslated regions and proximal region of the CoV genomes. These molecules will serve as chemical probes to further understand CoV RNA biology and can pave the way for the development of specific CoV RNA–targeted antivirals.
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TissueNexus: a database of human tissue functional gene networks built with a large compendium of curated RNA-seq data
Abstract: Mapping gene interactions within tissues/cell types plays a crucial role in understanding the genetic basis of human physiology and disease. Tissue functional gene networks (FGNs) are essential models for mapping complex gene interactions. We present TissueNexus, a database of 49 human tissue/cell line FGNs constructed by integrating heterogeneous genomic data. ...
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Center for RNA Biomedicine
We are pleased to announce the publication of our second annual magazine and report, RNA Translated. This year's issue focuses on RNA therapeutics research. It is, in a way, the continuation of RNA Translated, 2020, The Year of the RNA Virus.
Read more
rna.umich.edu
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