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Li-Huei Tsai, Ph.D.
Director, Picower Institute for Learning and Memory
Picower Professor of Neuroscience
Department of Brain and Cognitive Sciences
Director, The Alana Down Syndrome Center
Director, the Aging Brain Initiative
Massachusetts Institute of Technology
Professor Li-Huei Tsai is the Director of the Picower Institute for Learning and Memory at the Massachusetts Institute of Technology, a Picower Professor of Neuroscience, and an Associate Member of the Broad Institute. She obtained her Ph.D. from the University of Texas Southwestern Medical Center in Dallas and completed her postdoctoral training at Cold Spring Harbor Laboratories and Massachusetts General Hospital. Tsai is interested in elucidating the pathogenic mechanisms underlying neurological disorders that impact learning and memory. She uses multi-omic approach to decipher the pathophysiology of Alzheimer’s dementia. Her team pioneered the use of patient-derived induced pluripotent stem cell (iPSC) to produce cerebral organoids and other brain cell types that model AD pathology. Tsai is a Fellow of the American Association for the Advancement of Science, a Fellow of the National Academy of Inventors, a Member of the National Academy of Medicine, an Academician of the Academia Sinica in Taiwan, and a Member of the American Academy of Arts and Sciences. She is a recipient of the Mika Salpeter Lifetime Achievement Award, and the 2018 Hans Wigzell Research Foundation Science Prize for her research on Alzheimer’s disease. In 2022 she was named a Visiting Professor of the Vallee Foundation.
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