UCSF CCMBM Core Services Newsletter - July 2022
“As a longtime member of the CCMBM and Orthopaedic Surgeon Investigator interested in musculoskeletal research, the Center has helped me significantly with networking through the Imaging Core. With the support of the CCMBM, I was able to complete publications and related analyses. As a result, I was awarded a $50,000 Seed Grant and am primed for NIH funding.”
 
-- Alan Zhang, MD, Associate Professor of Orthopaedic Surgery at UCSF, Director of UCSF Sports Medicine Fellowship Program and the Hip Preservation Center.
Interested in exploring relationships between muscle size, fat distribution, and bone structure? The Imaging Core supports Soft Tissue Analysis (STA) on High Resolution peripheral Quantitative CT (HR-pQCT) scan data. STA is a technique for automated segmentation and analysis of muscle and fat within CT data. The Imaging Core can help analyze existing data or design a new study to evaluate soft tissue and bone parameters. Contact Galateia Kazakia, Imaging Core Co-Director, for more information.     
Above image: Muscle, fat, and bone separation in the tibia of a human subject. Data were acquired and analyzed on a Scanco HR-pQCT system.
Did you miss our last seminar, technical workshop, or other event? Or are you looking for imaging equipment or skeletal biology standard operating protocols? Members have access to workshops, seminars and retreat session recordings, protocols, and archived newsletters on the CCMBM Members Only Site. Never miss out on all things related to the Center!

Contact Pui Yee Law for login assistance or questions on the members only site.
The Imaging Core is offering service discounts to Early Stage Investigator and Trainee members. The Epidemiology, Biostatistics and Study Design Core is also offering up to 6 hours of free UCSF Clinical and Translational Institute (CTSI) consultation time for all CCMBM members. Please contact each Core to utilize these member discounts.

Please contact Pui Yee Law for eligibility questions. 
A Picture of Pain: Advancement in Management and Treatment

Mark your calendars for the CCMBM/REACH/Orthopaedic Surgery Spring Scientific Retreat scheduled for February 28 - March 1, 2023. Location and event details will be forthcoming as we draw closer to the retreat.
September 28, 4:00pm; Virtual Event
Jason Daniel Buenrostro, PhD, Assistant Professor of Stem Cell and Regenerative Biology, Harvard University
Single-cell Epigenomics: Gene regulation at unprecedented resolution
Hosted by Biomedical Sciences Graduate Program
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September 28, 6:00pm; InterContinental Hotel, San Francisco
Learn new and evolving concepts in trauma and fracture management through didactic lectures, case presentations, and hands-on practice with the latest implants from international leaders in the field of orthopaedic traumatology. This course is of substantial value in the preparation for board and recertification examinations.
Hosted by Orthopaedic Trauma Institute
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September 28, 6:00pm; Virtual Event
This session will present the latest understanding of atypical femoral fracture management, including pathological mechanisms, surgical strategies, and future research directions. Atypical femoral fractures provide us with a continual challenge in orthopedics. These fractures have both mechanical and biological issues which until recently were poorly recognized, yet complications remain common. Registration required.
Hosted by ORS International Fracture Repair Section and Orthopaedic Trauma Association
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September 29-October 1, 7:00am; InterContinental Hotel, San Francisco
Learn new and evolving concepts in trauma and fracture management through didactic lectures, case presentations, and hands-on practice with the latest implants from international leaders in the field of orthopaedic traumatology. This course is of substantial value in the preparation for board and recertification examinations.
Hosted by Orthopaedic Trauma Institute
September 29, 12:00-1:00pm; Virtual Event
James Ferrell, MD, PhD, Professor of Chemical and Systems Biology and of BiochemistryStanford University
Cytoplasmic self-organization and dynamics
RSVP to receive Zoom details.
Hosted by Biophysics Graduate Program
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October 19, 11:00am; Mission Bay, HD-160
This mini-symposium will focus on pre-clinical imaging and therapeutic capabilities as well as access to high-end, clinically translatable pre-clinical imaging technology in order to improve research, innovation, and clinical impact of grant proposals. Key Presenters: Juan Antonio Camara Serrano, DVM, PhD; Renuka Sriram, PhD; and Youngho Seo, PhD.
Hosted by Helen Diller Family Comprehensive Cancer Center
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October 26, 2:00-3:00pm; Parnassus, N-217
Warren Grayson, PhD, Inaugural Director of the Atlantic Charter Discovery Center for Musculoskeletal Recovery at the Spaulding Research Institute, Harvard Medical School.
"Decoding Neurovascular Interactions to Promote Musculoskeletal Regeneration"
Hosted by CCMBM and HIVE
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October 27, 8:00am-5:00pm & October 28, 8:00am-12:00pm; Parnassus, Millberry Union Conference Center, MUE-136A/B
The NSF Center for Disruptive Musculoskeletal Innovations (CDMI) is hosting its annual Fall Symposium next month. Our two-day hybrid event will be held in-person and via Zoom. Please join us for a variety of presentations and speakers from both industry and academia, IAB industry discussion, and voting on new CDMI projects. See the CDMI website for more info. RSVP required.
Hosted by CDMI
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October 27, 11:00am; Virtual Event
Presented by Lamya Karim, PhD, University of Massachusetts Dartmouth; and Ann Schwartz, PhD, UCSF
Advanced Glycation Endproducts and Skeletal Health
Hosted by ASBMR
FUNDING OPPORTUNITIES

LOI Deadline: October 4, 2:00pm 

This targeted PCORI Funding Announcement is seeking to fund high-quality, comparative clinical effectiveness research (CER) projects that focus on multimodal interventions to prevent fractures in people with osteoporosis and a history of a fracture.
The Program for Breakthrough Biomedical Research (PBBR) seeks to stimulate and support highly innovative basic science research at UCSF. The focus is on basic science projects of potentially high impact that are creative, risky, and transformative. We seek novel ideas for basic science projects that go beyond those that receive funding from NIH and other traditional funding mechanisms.

Proposal deadline: Friday November 4th, 2022 5:00 pm PDT

NFR - New Frontier Research - $25,000 - $150,000 for one year
• Supports basic science research projects at levels of risk and innovation that substantially exceed those
supported by NIH; multiple awards annually
• Both single-PI and multiple-PI applications are welcomed

TMC - Technologies, Methodologies & Cores - $50,000 - $500,000 for one year in matching funds
• Strong emphasis on invention and development of new technologies, methodologies, and/or establishment of
technology cores and acquisition of shared instruments; multiple awards annually
• Both single-PI and multiple-PI applications are welcomed

Please send inquiries to Linda Reilly, PBBR Program Manager.
ACKNOWLEDGING THE CCMBM

If you have received a CCMBM grant, used one of our cores, or formed a collaboration at one of our events that led to a publication, please acknowledge our Center in related publications and presentations. We suggest stating:

Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number P30AR075055. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.