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CCMBM Cores:
Featured Services
The Core Center for Musculoskeletal Biology & Medicine (CCMBM) defines itself
by emphasizing musculoskeletal-specific education and services that are critical to its members but not available elsewhere in the university system.
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“As a member of the CCMBM, I utilized the Skeletal Biology and Biomechanics (SBB) Core to section and stain bone, and to assay for key markers of resorption and deposition. The SBB Core also played a key role in imaging these samples, which allowed us to obtain critical data for an R01 renewal and a manuscript submission.”
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How strong is YOUR skeleton?
The musculoskeletal system has the functional task of withstanding substantial stress during the course of locomotion and strenuous activities such as weightlifting or sprinting. However, its remarkable biomechanical behavior is impaired by aging and in certain diseases. The Skeletal Biology and Biomechanics (SBB) Core offers testing for measuring the biomechanical behavior of load-bearing tissues, including bone.
SBB Core Service - Bending Test
Bending tests are useful for measuring the flexural properties of femurs or other long bones from rodents and other small animals. The SBB core includes electromechanical (BOSE ELF 3200) testing capabilities, which allow ex vivo testing in 3-point bending using standardized protocols. The SBB Core also offers comprehensive data analysis and interpretation.
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Left: Diagram of 3-point bending test performed on excised rat ulna. The ulna is placed on two supports and a third point applies a downward load to the mid-diaphysis. Center: Typical load data acquired during 3-point bending are converted to bending moments and then plotted versus normalized displacement. This allows determination of ulnar rigidity, yield moment, and ultimate moment. Right: Yield moment data for a recent study of diabetic bone fragility conducted by Aaron Fields’ lab. Type 2 diabetes is a risk factor for fragility fractures. Ulnae from a rat model of type 2 diabetes have 23% lower yield moments compared to ulnae from obese non-diabetic rats (ap < 0.01) and lean control rats (bp < 0.01). Data are mean ± SEM for 6 rats/group.
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February 28-March 1, 2023, Mission Bay, Genentech Hall
Join this scientific event, entitled “A Picture of Pain: Advances in Management and Treatment” to explore the mechanistic foundations of pain science and how they intersect with musculoskeletal biology. RSVP now to secure your spot!
Remote participation is available by request.
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Application Deadline: February 27, 2:00 PM
Established Investigators - $50,000 max; Early Career Investigators - $40,000 max. Research topics should be translational in nature and related to musculoskeletal disease. If you have any research questions in regards to applying, please contact Pui Yee Law.
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March 3, 12:30-2:00pm PT / 3:30-5:00pm ET, Virtual Event
Zehra Akkaya, PhD, Postdoctoral Scholar of Radiology, UC San Francisco. "Body Compositional Changes in Long Term HIV Infection under Effective Antiretroviral Treatment: Decoupling of Spinal and Femoral Bone Marrow Adiposity in People Living with HIV"
Seanna Yoon, PhD, Postdoctoral Research Fellow, Endocrine Unit, Mass General Hospital. "The role of salt inducible kinases in renal fibrosis"
Hosted by CCMBM & CSR
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March 10, 10:00-11:00am; Virtual Event
Investigators can present their clinical research grants or data and receive feedback and informal consultation from peers and senior investigators. Members are invited to join to learn from this session. RSVP for Zoom details.
Hosted by CCMBM EBSD & Imaging Cores
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Did you miss our last seminar, technical workshop, or other event? Or are you looking for imaging equipment or skeletal biology standard operating protocols? Members have access to workshops, seminars and retreat session recordings, protocols, and archived newsletters on the CCMBM Members Only Site. Never miss out on all things related to the Center!
Contact Tom Sullivan f or login assistance or questions on the members only site.
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The Imaging Core is offering service discounts to Early Stage Investigator and Trainee members. The Epidemiology, Biostatistics and Study Design Core is also offering up to 6 hours of free UCSF Clinical and Translational Institute (CTSI) consultation time for all CCMBM members. Please contact each Core to utilize these member discounts.
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February 22, 7:30am; Mission Bay, GenHall - Byers Auditorium
Hunter Warwick, MD, Resident at Department of Orthopaedic Surgery, UCSF
Efficiency in Orthopaedics: Strategies to Optimize the Surgical Process
Hosted by UCSF Department of Orthopaedic Surgery
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February 22, 11:00am-12:00pm; Virtual Event
Grace O'Connell, PhD, Associate Professor and Associate Dean in the College of Engineering, University of California, Berkeley
Hosted by L.I.S. BioConsulting
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February 22, 11:00am; Mission Bay, Mahley Auditorium
Bart De Strooper, MD, PhD, Professor at University of Leuven and University College London, Director at UK Dementia Research Institute
Microglia and astroglia contributions to Alzheimer’s Disease
Hosted by UCSF Weill Institute for Neurosciences & Gladstone Institutes
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February 22, 11:30am-1:00pm; Mission Bay, HD-291
Hosted by Helen Diller Family Comprehensive Cancer Center
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February 22, 12:00pm; Mission Bay, Rock Hall, Auditorium RH102
Jesse Dixon, MD, PhD, Assistant Professor, Gene Expression Laboratory, Salk Institute
Hosted by Program in Pharmaceutical Sciences and Pharmacogenomics
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February 22, 4:00pm; Parnassus, N-225
Elaine Lim, PhD, Assistant Professor of Molecular, Cell, and Cancer Biology, UMass Chan Medical School
"Transcriptomics-based dissection of cell type interactions using cerebral organoids in Autism and Alzheimer’s Disease"
Hosted by Biomedical Sciences Graduate Program
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February 22, 5:00-7:00pm; Mission Bay, MH-1407
Ricardo Espinosa Lima, PhD Student, UCSF
Rose Zhou, DSCB Rotation Student, UCSF
RSVP to receive Zoom details.
Hosted by Developmental & Stem Cell Biology Graduate Program
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February 23, 11:00am; Mission Bay, Mahley Auditorium
Anne Brunet, PhD, Professor of Genetics, Stanford University
Hosted by UCSF Weill Institute for Neurosciences & Gladstone Institutes
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February 23, 12:00-1:00pm; Virtual Event
Tingting Yang, PhD, Associate Professor of Ophthalmic Sciences, Columbia University
The structure and function of bestrophins
Hosted by Biophysics Graduate Program
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February 23, 12:00-1:00pm; Parnassus, N-225
Jingwen Ding, BMS Student, UCSF
Maddie Urbanek, BMS Student, UCSF
Hosted by Biomedical Sciences Graduate Program
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February 24, 12:00pm; Parnassus, HSW-302
Emily Corrigan, DSCB Student, UCSF
Sneha Rao, DSCB Rotation Student, Crouch Lab, UCSF
RSVP to receive Zoom details.
Hosted by Developmental & Stem Cell Biology Graduate Program
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February 24, 3:00-4:00pm; Mission Bay, HD-160
Henry Kim, MD, PhD, Professor of Pharmacology, Yonsei University College of Medicine
Prediction of genome editing tool efficiencies and functional evaluation of genetic variants
Hosted by Helen Diller Family Comprehensive Cancer Center
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February 27, 9:00-10:00am; Parnassus, N-225
Aviv Regev, PhD, Head and Executive Vice President, Genentech Research and Early Development
Hosted by ImmunoX
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February 28, 9:00am-12:00pm; Mission Bay, Genentech Hall, Byers Auditorium
QBI and Institute Pasteur scientists talk facilitating research innovation at the interface of infectious biology and quantitative sciences.
Hosted by Institut Pasteur and the Quantitative Bioscience INstitute
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February 28, 10:00-11:00am; Virtual Event
Rosa Rodriguez, Graduate Student, Microbiology and Immunology, Sil Lab, UCSF
"Discovery of a new family of virulence factors in the human fungal pathogen Histoplasma capsulatum"
Hosted by iMicro
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February 28, 11:30am-1:00pm; Virtual Event
Haley Ogasawara, CCB Student, UCSF
Thu Pham, PSPG Student, UCSF
Dani Rodea, Biophysics Student, UCSF
Connie Silva, PSPG Student, UCSF
RSVP to receive Zoom details.
Hosted by PhD Degree Program in Biophysics
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February 28, 12:00-1:00pm; Virtual Event
Hosted by UCSF Center for Faculty Educators
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February 28, 1:00-2:30pm; Parnassus, HSW-300
Lydia Finley, PhD, Associate Member, Cell Biology Program Memorial Sloan Kettering Cancer Center
“Metabolic regulation of cell fate decisions”
Hosted by UCSF Broad Stem Cell Center
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Application Deadline: March 17, 2023
Applications should be mailed as a single PDF to LTI@ucsf.edu by close of day March 17, 2023.
If you have any questions, please reach out to Cammie Edwards, Director, Living Therapeutics Initiative: cammie.edwards@ucsf.edu.
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Application Deadline: March 31, 2023
The HHMI Investigator Program competition is open to basic researchers and physician scientists in basic biological and biomedical sciences in many scientific disciplines, at hundreds of institutions. Candidates apply directly to HHMI. Applications must be received by March 21, 2023. Information about this program and competition, including benefits of becoming an HHMI Investigator, may be found on the program page.
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Application Deadline: April 1, 2023
The Grant Development Award provides funding for a junior CCMBM member to host a meeting (e.g., lunch or dinner) with 2–3 UCSF faculty members who are outside of the trainee’s current lab to:
1) brainstorm/solicit informal feedback on a study idea or research direction
2) learn about the latest methods and techniques used in related fields
3) identify potential collaborators
4) promote inter-disciplinary MSK research
5) expand the trainee’s professional network
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Recognizing the need for collaboration of MSK scientists with experts outside of the MSK field, we are providing support to MSK Center members to host a meal for a creative and enjoyable in-person networking meeting to stimulate these interactions and to further develop new research ideas and plans to fund them. Faculty, staff, and trainees who are MSKC/CCMBM members are encouraged to apply to host an event.
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ACKNOWLEDGING THE CCMBM
If you have received a CCMBM grant, used one of our cores, or formed a collaboration at one of our events that led to a publication, please acknowledge our Center in related publications and presentations. We suggest stating:
Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number P30AR075055. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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