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Asian Biotechies Walk Into A Bar


A Newsletter from InScienceWeTrust Community & BioAdvisory


Issue_002, 2023-06-25

In the past 2 weeks, our newsroom has seen the chatter about AstraZeneca's potential spin-off of their China business, the AbbVie lawsuit against BeiGene on Brukinsa, PhRMA's decision to join Merck, BMS, and others to sue the US government over the IRA, and some impressive M&A deals.


The highlight of this newsletter is the @Philly CGT (Cell and Gene Therapy) Annual Conference 2023 attended by many ISWT-C members. Despite being the second time of running the conference, @Philly CGT conference 2023 was so impactful that that it attracted KOLs such as James Wilson and Katherine High, the FDA CBER chief Peter Marks, and many leading CGT companies. The roundtable, hosted by three ISWT-C members and titled Do and Don't in Getting Your Out-Licensing Deal Done, made a strong impression. Check our conference report here.

News & Events That Matter To Asian Biotech


2023-06-23 Biotech Hangout podcast continued to impress! The hosts covered the Eli Lilly/DICE Therapeutics M&A for $2.4B, Riovant's positive data in IBD, eyebrow-raising trading behaviors of biopharma insiders, why FTC's lawsuit against Amgen/Horizon M&A is largely a political play, an investigative article from STAT News on the "unethical" practice of PBM, and drug pricing issue in light of the approval of Sarepta's Elevidys for DMD with a $3.2M price tag. Finally, they elaborated extensively on the performance of those big academia/industries alliances that involved hundreds of millions of dollars.


2023-06-22 PhRMA, the trade group of biopharma companies in the US, joined a few biopharma companies and the U.S. Chamber of Commerce to sue the US government over Inflation Reduction Act's drug pricing practice (IRA). When IRA was passed last year, many experts predicted lawsuits from the industry, and we have been seeing this prediction being realized in recently.


2023-06-18 AstraZeneca is allegedly considering to spin off its China business and list it on HKEX, based on a Financial Times article HERE. Conversely, AstraZeneca's emerging markets head Leon Wang refuted this as a "rumor" in an exclusive Yicai Global article. This is one of the biggest news in China biotech space this week, since AZ's CEO Pascal Soriot has been speaking very highly of China as an important market at AZ's 1Q2023 earnings presentation and a critical source of innovations ASCO2023 corporate event.


In one LinkedIn post, one expert argues that the Financial Times rumor might pan out, based on the similar reports from other leading Western newspapers, the unusually quiet voices from the lawyers who might have insights, and his personal experiences from a similar situation involving another European MNC.


Our ISWT-Community member Bob Ai from Goby Global started a survey to collect the LinkedIn folks' prediction on this one. Give it a try. Additionally, ISWTC-Breakthrough WeChat group has been discussing on this topic, and contact our volunteers to get the copy of the full discussion.


2023-06-16 A recent Topline Podcast episode features our own Angus Liu, who shared interesting news from BIO2023 and ASC02023. Angus Liu hosted two panel discussions at BIO2023 and covered news from Moderna, Jazz Pharmaceuticals, and a BD deal involved Asian biotech Hutchmed's fruqutinib.


2023-06-15 AbbVie sues BeiGene over alleged patent infringement on Imbruvica, reported by ISWT-Community volunteer Angus Liu. The recent Phase 3 ALPINE win of Brukinsa vs Imbruvica triggered the NCCN to recommend Brukinsa over Imbruvica in several indications in the NCCN guideline, the most authoritative guidance in the US. JP Morgan suggested the 10%+ rout of BeiGene stock was "overreacting" and forecast a "...modest royalty and/or one-time payment as a potential worst-case scenario outcome for BeiGene...". It's worth noting that AbbVie sued AstraZeneca in 2017 over its BTK Calquence, which was settled with an undisclosed terms in 2019.

News & Events In ISWT Communities


2023-06-24 In the AtPhilly Annual CGT Conference, organized by SAPA-GP, ISWT-Community members Wendy Pan from Goodwin, Pan Pan from Akeso Bio, Laura Nan from MiG, and Leon Tang from InScienceWeTrust BioAdvisory hosted a well-received BD roundtable titled "The Do and Don't In Getting Your Out-licensing Deals Done".


In this 2.5-hour session, we discussed the encouraging trend of cross-border BD deals between the East and the West, the reason why BD is essential to survive the current capital winter for Asian biotech companies, why early-stage biotech companies and investors need not to worry too much about the seemingly aggressive FTC but do need to pay close attention to CFIUS, the likely continuation of the current ADC boom, and more.


Everyone enjoyed the incredible energy, the high-quality questions & comments from biotech executives, the insightful and sometimes thought-provoking opinions, and the great rapport bubbling up out of the lively discussion. The roundtable session was well received, and kudos to the impressive SAPA-GP team for putting this together.


Please check our conference notes to learn other highlights.


2023-06-18 E药经理人 article 亲历Biotech破产潮:贪婪在左,死亡在右 features ISWT-Community's founder Leon Tang. This article highlights some key challenges facing the China biotech and it also provides some historic references to explain the reasons that might have caused the current stressful situation of China biotech.


Job posts from ISWT Community members


A top private Chinese biopharma company looking for candidates with ADC expertise (chemistry, preclinical) open to consulting or full time position - location flexible. Initially posted on 2023-06-15. Contact us for more information.


一中国知名大型民营企业急招大分子药物研究 SVP/VP,负责生物大分子药物开发及团队管理工作。候选人要求有博士学位,具有10年以上生物大分子药物开发及团队管理经验,独立主持过生物大分子项目研究,应具备国际生物药物公司大分子药物发现与评价、工艺开发等团队及项目管理经验,有开发抗体、重组蛋白类药物、ADC 等大分子药物并成功申报 BLA 的经验。工作地点在上海张江。Initially posted on 2023-06-15. Contact us for more information.


A MNC biopharma is looking for a S&E BD head in China and reports to the SVP of the BD team at the company. Initially posted on 2023-06-15. Contact us for more information.

Previous Newsletters


Issue_001 on 2023-06-15: The inauguration issue of our newsletter "Asian Biotechies Walk Into A Bar".

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