Update on SARS-CoV-2 Omicron Variant of Concern
December 6, 2021
The Omicron variant continues to spread and has now been identified in over 50 countries, and in 17 states within the US. No Omicron cases have been detected, at this time, in Orange County. The Delta variant continues to be the predominant variant of SARS-CoV-2 identified in the US. Available data continues to support the use of existing mitigation measures (vaccination, including boosters, masking, testing, and hand washing) against the Omicron variant.
Recommendations for Providers
Existing COVID-19 diagnostic tests (PCR and antigen) can detect infection caused by the Omicron variant. Omicron can only be specifically identified via whole genome sequencing (WGS). Mutations in the Omicron variant produce a pattern of PCR results termed S gene dropout or S gene target failure (SGTF) with the ThermoFisher TaqPath SARS-CoV-2 Combo RT-PCR assay. Providers receiving positive SARS-CoV-2 results indicating SGTF should report them immediately to OCHCA.
 
Providers should ask about international travel in patients when assessing or testing for COVID-19. While all positive COVID-19 cases are reportable, positive cases who traveled internationally in the last 14-days or had exposure to persons with recent international travel should be reported immediately to OCHCA. PCR testing is preferred at this time for suspect cases with recent international travel, as it affords an opportunity to do WGS on the initial specimen.
 
On Friday CDPH released an updated statement on Omicron via CAHAN and will update information as needed on its Omicron Variant Fact Sheet page.
Guidance for Returning Travelers
  • All returning international travelers should be tested for SARS-CoV-2 3-5 days after return, regardless of immunization status.
  • Travelers who are not fully vaccinated should self-quarantine for 7 days, even if they test negative.
  • Travelers should monitor for COVID-19 symptoms and get tested if symptoms occur.

For questions or concerns, please contact the Communicable Disease Control Division at 714-834-8180.
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