Developing & advancing new HP MRI technology to better
detect, understand, and treat human diseases worldwide
Growing International Efforts
With 65+ human research publications and now 15 sites conducting human research, it is clear across international sites that HP C-13 technology is rapidly expanding. With this exciting growth comes the opportunity to come together as a HP C-13 community to collaborate and create research consensus recommendations.  

In this newsletter, we highlight international updates and recent efforts to discuss how HP C-13 MRI research is conducted and compared across sites. Also, read below for website updates that feature amazing video presentations that focus on clinical translation of HP C-13 imaging.

Best regards,
The HMTRC team & Collaborators


International Milestones & Achievements
HP C-13 MRI Consensus Contributors Group
As one major focus of our P41 Center Renewal we kicked off the HP C-13 Consensus Contributors Group at our March 2022 HMTRC workshop. Since then, we have been gathering with members of the community, structuring leadership roles, and establishing the process of reaching a consensus.

Interested in becoming part of the HP C-13 Contributors Group? Email [email protected]. This group meets monthly Thursdays (timing varies) and there are opportunities to contribute virtually. Watch our three most recent meetings below:

6/2/22 Consensus Meeting
(20 min)

(22 min)

6/23/22 Consensus Meeting
(60 min)
Human C-13 Research - Now at 15 Sites Strong!
We are excited to celebrate with the Copenhagen group their first Human HP C-13 MRI study! This now totals 15 sites worldwide that are conducting human research studies!
International Clinical Publication Highlights
International articles
to inspire & drive your basic and clinical research
HP 13C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell Carcinoma
Ursprung S, Woitek R, McLean MA, Priest AN, Crispin-Ortuzar M, Brodie CR, Gill AB, Gehrung M, Beer L, Riddick ACP, Field-Rayner J, Grist JT, Deen SS, Riemer F, Kaggie JD, Zaccagna F, Duarte JAG, Locke MJ, Frary A, Aho TF, Armitage JN, Casey R, Mendichovszky IA, Welsh SJ, Barrett T, Graves MJ, Eisen T, Mitchell TJ, Warren AY, Brindle KM, Sala E, Stewart GD, Gallagher FA


Predicting Response to Radiotherapy of Intracranial Metastases with Hyperpolarized 13C MRI

Lee CY, Soliman H, Bragagnolo ND, Sahgal A, Geraghty BJ, Chen AP, Endre R, Perks WJ, Detsky JS, Leung E, Chan M, Heyn C, Cunningham CH

with 65+ Human Publications!

The HMTRC Website. What's New?
New Seminar Presentations
Visit or re-visit some recent video presentations on
advances in HP 13C MRI Research for Clinical Translation.
Call for Seminar Presenters
We are currently looking for March presenters for our International HP C-13 MRI Seminar. Present new findings, publications, or other work in preclinical and human research. Presentations are 25 minutes with a
5-minute Q&A. Email us at [email protected].
New People. New Roles. One Great Mission.
The center welcomes 2 amazing team members to support the mission to better detect, understand, and treat human diseases using HP MRI technology. Details below on how they work to support you & the center.
Recent HMTRC Publications
 Check out these recently published articles to
inspire & drive your basic and clinical research.

Kinetic analysis of multi-resolution hyperpolarized 13C human brain MRI to study cerebral metabolism

Hu JY, Kim Y, Autry AW, Frost MM, Bok RA, Villanueva-Meyer JE, Xu D, Li Y, Larson PEZ, Vigneron DB, Gordon JW


Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [13C,15N2]urea + [1-13C]pyruvate simultaneous perfusion and metabolic imaging

Liu X, Tang S, Mu C, Qin H, Cui D, Lai YC, Riselli AM, Delos Santos R, Carvajal L, Gebrezgiabhier D, Bok RA, Chen HY, Flavell RR, Gordon JW, Vigneron DB, Kurhanewicz J, Larson PEZ

Whole-Abdomen Metabolic Imaging of Healthy Volunteers Using Hyperpolarized
[1- 13C]pyruvate MRI

Lee PM, Chen HY, Gordon JW, Wang ZJ, Bok R, Hashoian R, Kim Y, Liu X, Nickles T, Cheung K, Alas FL, Daniel H, Larson PEZ, von Morze C, Vigneron DB, Ohliger MA

Hyperpolarized 1-[ 13C]-Pyruvate Magnetic Resonance Imaging Detects an Early Metabolic Response to Immune Checkpoint Inhibitor Therapy in Prostate Cancer

de Kouchkovsky I, Chen HY, Ohliger MA, Wang ZJ, Bok RA, Gordon JW, Larson PEZ, Frost M, Okamoto K, Cooperberg MR, Kurhanewicz J, Vigneron DB, Aggarwal R

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The Hyperpolarized MRI Technology Resource Center (HMTRC) is supported by the National Institute of Biomedical Imaging and Bioengineering
(NIH P41EB013598) and focuses on the development and dissemination of new advances in dissolution DNP techniques and instrumentation, specialized data acquisition methodology, and analysis software for biomedical research. 
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