The RNA Transcript, November 2, 2020 |
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In this video (5' 28"), they present their research topic, respectively on ovarian cancer and prostate cancer, as well as their motivation and interests in RNA research.
The Alumkal lab is also recruiting a postdoc and a senior scientist: https://alumkal.lab.medicine.umich.edu/
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“Tumors taking the short cut: CDK12 and CDK13 in early transcription termination and nuclear RNA surveillance”
“Targeting U2AF: A vulnerable rheostat of pre-mRNA splicing”
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Tuesday, November 10, 3:00 PM EST | Harvard Medical School RNA Medicine Seminar
“Y Chromosome LncRNAs and Radiation Sensitivity in Lung Cancer: Don’t Lose Your Maleness!”
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Registration and abstract submission for the 2020 Bay Area RNA Conference are now open: https://barc.ucsf.edu
Once you are registered, you may submit speaker/poster presentation abstracts on your profile page, ie “Submit a New Presentation.” Deadline for abstract submissions has been extended to November 21.
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SAVE THE DATE: Thursday, December 10, 1:00-4:45 | University of Michigan Nobel Prize Symposium
1:15-1:50: Nils G. Walter, Francis S. Collins Collegiate Professor of Chemistry, Biophysics and Biological Chemistry, Professor of Chemistry, Professor of Biophysics, College of LSA, and co-director of the Center for RNA Biomedicine
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Our members' publications are available through Altmetric. Five queries are currently available: "RNA," "microRNA," "Transcriptome," "Translation," and "Molecule." Please make sure to have at least one of these key words in your title or abstract. Below is a recent highlight.
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High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance
David B. Lombard, William J. Kohler, Angela H. Guo, Christi Gendron, Melissa Han, Weiqiao Ding, Yang Lyu, Tsui-Ting Ching, Feng-Yung Wang, Tuhin S. Chakraborty, Zaneta Nikolovska-Coleska, Yuzhu Duan, Thomas Girke, Ao-Lin Hsu, Scott D. Pletcher, and Richard A. Miller, Science Advances, 02 Oct 2020, Vol. 6, no. 40, eaaz7628,
Abstract
Aging is the dominant risk factor for most chronic diseases. Development of antiaging interventions offers the promise of preventing many such illnesses simultaneously. Cellular stress resistance is an evolutionarily conserved feature of longevity. Here, we identify compounds that induced resistance to the superoxide generator paraquat (PQ), the heavy metal cadmium (Cd), and the DNA alkylator methyl methanesulfonate (MMS). Some rescue compounds conferred resistance to a single stressor, while others provoked multiplex resistance. Induction of stress resistance in fibroblasts was predictive of longevity extension in a published large-scale longevity screen in Caenorhabditis elegans, although not in testing performed in worms and flies with a more restricted set of compounds. Transcriptomic analysis and genetic studies implicated Nrf2/SKN-1 signaling in stress resistance provided by two protective compounds, cardamonin and AEG 3482. Small molecules identified in this work may represent attractive tools to elucidate mechanisms of stress resistance in mammalian cells.
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A new, multidisciplinary cancer research grant is available to U-M graduate students and postdocs.
The Richard G. Hankett Memorial Grant Foundation (RGHG) supports university-level multidisciplinary scientific studies on viral and bacterial infection-induced cancers. We welcome graduate student and postdoctoral scientists from chemistry, pharmacology, biochemistry, engineering, biology, and any related disciplines to apply for our 2021 grant.
The RGHGF is a crowd-funded research grant started by four U-M alumni. It offers approximately $13,500-14,000 to support academic research projects. Applications for the Fall 2021 grant are due by April 1, 2021.
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