The RNA Transcript, August 23, 2021 |
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Join over 150 faculty in RNA sciences:
The University of Michigan has three tenure-track positions for RNA scientists
Application deadline: September 15, 2021
The University of Michigan (U-M) Center for RNA Biomedicine welcomes applications from outstanding scientists in any area of RNA research, with particular emphasis on RNA drug targeting or as medicine, structural biology of RNA nanomachines, RNA structural in vivo profiling, RNA protein interaction profiling, and in-vivo analysis of long non-coding RNA function.
At the Center for RNA Biomedicine, we are committed to DEI and expect our members and partners to share these values. Women and underrepresented minorities are strongly encouraged to apply. The University of Michigan is supportive of dual-careers and is an equal opportunity/affirmative action employer.
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“Regulation of neurodegeneration-linked RNA-binding proteins by nuclear import receptors and post-translational modifications”
Dorothee Dormann, Ph.D.
"Small RNAs and epigenetic inheritance"
René Ketting, Ph.D.
Moderator: Julian König, Ph.D.
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Monday–Wednesday, September 20–22, RiboClub Meeting (Virtual)
Late registration (no abstract) deadline is September 1, 2021
"Transcriptomics and cancer biology"
Keynote speakers:
Tom Cech, University of Colorado Boulder, USA
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For press releases and blog articles about your upcoming top journal publications, please
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Our members' publications are available through Altmetric. Five queries are currently available: "RNA," "microRNA," "Transcriptome," "Translation," and "Molecule." Please make sure to have at least one of these key words in your title or abstract. Below are recent highlights.
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https://doi.org/10.1038/s41580-021-00382-6
Abstract: .... In this Review, we discuss the four major mechanisms by which expansion of short tandem repeats causes disease: loss of function through transcription repression, RNA-mediated gain of function through gelation and sequestration of RNA-binding proteins, gain of function of canonically translated repeat-harbouring proteins, and repeat associated non-AUG translation of toxic repeat peptides. ... Lastly, we propose that lynchpins tying these disease mechanisms and native functions together offer promising therapeutic targets with potential shared applications across this class of human disorders.
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Sleep loss drives acetylcholine- and somatostatin interneuron-mediated gating of hippocampal activity, to inhibit memory consolidation, James Delorme, Lijing Wang, Femke Roig Kuhn, Varna Kodoth, Jingqun Ma , Jessy D. Martinez, Frank Raven, Brandon A. Toth, Vinodh Balendran, Alexis Vega Medina, Sha Jiang, Sara J. Aton, PNAS,
Abstract: Sleep loss disrupts consolidation of hippocampus-dependent memory. ... Together, our data suggest that state-dependent gating of DG activity may be mediated by cholinergic input and local Sst+ interneurons. This mechanism could act as a sleep loss–driven inhibitory gate on hippocampal information processing.
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High-throughput splicing assays identify missense and silent splice-disruptive POU1F1 variants underlying pituitary hormone deficiency, Peter Gergics, Cathy Smith, Hironori Bando, Alexander A.L. Jorge, Denise Rockstroh-Lippold, Sebastian A. Vishnopolska, Frederic Castinetti, Mariam Maksutova, Luciani Renata Silveira Carvalho, Julia Hoppmann, Julián Martínez Mayer, Frédérique Albarel, Debora Braslavsky, Ana Keselman, Ignacio Bergadá, Marcelo A. Martí, Alexandru Saveanu, Anne Barlier, Rami Abou Jamra, Michael H. Guo, Andrew Dauber, Marilena Nakaguma, Berenice B. Mendonca, Sajini N. Jayakody, A. Bilge Ozel, Qing Fang, Qianyi Ma, Jun Z. Li, Thierry Brue, María Ines Pérez Millán, Ivo J.P. Arnhold, Roland Pfaeffle, Jacob O. Kitzman, Sally A. Camper, The American Journal of Human Genetics (2021), https://doi.org/10.1016/j.ajhg.2021.06.013.
Often overlooked because they might not alter the amino acid production, splicing defects can play an important role in rare genetic pituitary gland diseases.
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The University of Michigan BioInnovations in Brain Cancer Initiative (BIBC) invites applications for a tenure-track position at any level in brain cancer biology and technology research (including, drug/molecular transport/imaging in the brain tissue; translation-focused glioma, epigenetics and/or scRNA-seq research; and non-viral nucleic acid delivery).
Applications will be accepted on a rolling basis, but review of applications will begin on October 1, 2021.
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