The RNA Transcript, June 6, 2022 |
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Michael McMillan is a Ph.D. student in the Sami Barmada lab. His research focuses on identifying molecular mechanisms of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Specifically within ALS, Michael is focused on how RNA modifications influence RNA stability that may contribute to disease pathogenesis. Read more about Michael in this week's RNA Featured Researcher.
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>> TODAY <<
U-M RNA Innovation Seminar
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Long non-coding RNAs as evolutionarily fluid chromatin weavers
LANGEBIO, Cinvestav
Monday, June 6, 2022
4:00 pm - 5:00 pm
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U-M Oral Dissertation Defense |
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Molecular Mechanisms of Subcellular Development: Down Syndrome-Related Genetic Interactions and Axon-Dendrite Coordination During Neurodevelopment
Monday, June 6, 2022
10:00 - 11:00 AM
Palmer Commons, Forum Hall
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Harvard Medical School Initiative for RNA Medicine |
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Microfabricated hydrogel technologies for quantitative, multiplexed profiling of miRNA
Tuesday, June 7, 2022
3:00 - 4:00 PM
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U-M Center for Cell Plasticity and Organ Design (CPOD) |
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Genetic regulation of epithelial homeostasis and injury
Tuesday, June 7, 2022
4:00 - 5:00 PM
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>> THURSDAY <<
U-M RNA Student Postdoc Council's The RNA Function
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A networking event designed for U-M students and postdocs from across the university to hear what other groups are doing around campus.
Thursday, June 9, 2022
12:00 - 3:00 pm
BSRB, ABC Seminar rooms
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U-M Oral Dissertation Defense |
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Consequences of Uridine mRNA Modifications on Translation
Monday, June 13, 2022
10:00 - 11:00 AM
East Conference Room, Rackham
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U-M Oral Dissertation Defense |
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Mechanisms of Nutrient Sensing and Gene Regulation by the E. Coli Leucine-Responsive Regulatory Protein, a Global Feast-Famine Transcriptional Regulator Christine Ziegler, advisor: Peter Freddolino
Tuesday, June 14, 2022
2:00 - 3:00 PM
North Lecture Hall, Med Sci II
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U-M Oral Dissertation Defense |
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4D Nucleome-Guided Cellular Reprogramming Gabrielle Dotson, advisor: Indika Rajapakse
Wednesday, June 15, 2022
10:00 - 11:00 AM
West Lecture Hall, Med Sci II
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RNA Collaborative Seminar Series |
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----Wednesday, June 15, 2022
----10:00 pm - 11:00 am
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Catalyzing tRNA, mRNA or others? The multifaceted role of tRNA modifying enzymes
Structural insights into substrate targeting and inhibition of CRISPR-Cas systems
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Toronto RNA Enthusiasts' Day (TREnD)
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TREnD will be held online via Zoom/Fourwaves. Poster session & trainee talks on both days.
July 27 – 28, 2022
Toronto, Canada
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RiboClub Annual Meeting - Travel Fellowship |
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The RiboClub Society has set aside a limited amount of funds for fellowships to support students and postdoctoral fellows who otherwise would not be able to attend the meeting for financial reasons.
September 18 – 22, 2022
Quebec, Canada
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Pfizer is seeking proposals for the advancement of therapeutics in renal disorders
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Open for Submissions: April 25th - June 13th, 2022 |
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Catalyzing translational research efforts by supporting preclinical and commercial clinical development |
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Innovation Partnerships at the University of Michigan manages Great Lakes Discovery, a ten-year collaboration with Deerfield Management Company, L.P to fund U-M drug discovery from early-stage research to clinical development.
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Deerfield has committed up to $130 million over the next decade to invest in biomedical research at U-M with the aim of developing potentially life-saving drugs and disease treatments.
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Projects selected by Great Lakes Discovery will be provided funding and operational support through a development plan aimed at achieving Investigational New Drug (IND) readiness.
GET STARTED WITH A CONSULTATION There is no open Request for Proposal (RFP) - the first step for an interested researcher is to schedule a consultation with the program’s Scientific Collaboration Manager Dr. Seohee You (shyou@umich.edu).
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Our members' publications are available through Altmetrics. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation. Below are recent highlights.
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Highlights
- Long noncoding RNAs (lncRNAs) are tissue- and context-specific modulators of immune cell development, differentiation, activation, and function.
- lncRNA molecular mechanisms are diverse and challenging to predict.
- lncRNAs impact on the outcomes of protective and pathogenic immune responses in a variety of diseases.
- lncRNA genes outnumber protein-coding genes, but comparatively few lncRNAs have been functionally or mechanistically characterized.
- Further unlocking the role of lncRNAs in immunity may lead to improved outcomes for diseases that are influenced by protective and pathogenic immune responses.
Despite an ever-increasing appreciation of how protein-coding genes shape immune responses, the molecular underpinnings of immune regulation remain incompletely understood. This incomplete picture impedes the development of more precise therapeutics and diagnostics for immune-mediated diseases. Long noncoding RNAs (lncRNAs) are versatile cell- and context-specific regulators of gene expression and cellular function. The number of lncRNA genes rivals that of protein-coding genes; however, comparatively little is known about their function. Even though the functions of most lncRNA genes are unknown, multiple lncRNAs have recently emerged as important immune regulators. Therefore, further unlocking the role of lncRNAs in the mammalian immune system coupled with their tissue-specific expression might lead to more precise therapeutics and diagnostics for immune disorders in general.
Keywords: long noncoding RNA, immunity, autoimmunity, inflammatory immune disorders, alloimmunity, antitumor immunity
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Tsoi, L.C., Xing, X., Kahlenberg, J. M., Scott, V. E., & Gudjonsson, J. (2022). Noninvasive Tape-Stripping with High-Resolution RNA Profiling Effectively Captures a Preinflammatory State in Nonlesional Psoriatic Skin. Journal of Investigative Dermatology, 142(6), 1587–1596. https://doi.org/10.1016/j.jid.2021.09.038
Tape stripping is a minimally invasive, nonscarring method that can be utilized to assess gene expression in the skin but is infrequently used given technical constraints. By comparing different tape stripping technologies and full-thickness skin biopsy results of lesional and nonlesional psoriatic skin from the same patients, we demonstrate that tape stripping with optimized high-resolution transcriptomic profiling can be used to effectively assess and characterize inflammatory responses in the skin. Upon comparison with single-cell RNA-sequencing data from psoriatic full-thickness skin biopsies, we illustrate that tape-stripping efficiently captures the transcriptome of the upper layers of the epidermis with sufficient resolution to assess the molecular components of the feed-forward immune amplification pathway in psoriasis. Notably, nonlesional psoriatic skin sampled by tape stripping demonstrates activated, proinflammatory changes when compared to healthy control skin, suggesting a prepsoriatic state, which is not captured on full-thickness skin biopsy transcriptome profiling. This work illustrates an approach to assess inflammatory response in the epidermis by combining noninvasive sampling with high throughput RNA-sequencing, providing a foundation for biomarker discoveries and mechanism of action studies for inflammatory skin conditions.
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