The bottleneck that is the purification of oligos, peptides, mAbs and other therapeutics has been removed with YMC’s Contichrom continuous chromatography platform. Both bench jockeys and production people now have a proven means to significantly reduce time to market, resin cost and solvent / buffer consumption. Multiple GMP production sites have already employed YMC’s Contichrom systems to save million$ and accelerate product while reducing space – time for you to look into what multi-column technology can do for you.
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BioPharmGuy
Saw a guy on Reddit who started a business teaching people how he landed clients as a life coach. Thus he is now a life coach coach. Soon enough he will be teaching people how to teach people. "It's not a pyramid scheme, it's a reverse funnel system."
I know you've seen and heard enough "got my vaccine" stories to last a lifetime, but since I've been keeping many of you informed on Covid/vaccine info since Jan 2020, I thought it would be prudent to share that I have received dose #1 of that sweet Moderna nectar. There is now modified mRNA, encapsulated in lipid nanoparticles seeping into my body.
I remember my elation the morning the first vaccine data was released showing how well it worked. Receiving the actual vaccine was anticlimactic in comparison. Oh, except when a lady passed out in the post-vaccination observation area. Her husband was quick to allay everyone's concerns - she had an unrelated blood pressure disorder which meant faintings were part of her everyday life. Aaaaand exhale.
25 million Americans have now received at least one dose of Covid vaccine. If there were extreme side effects, they would be transparent by now. Make your appointment!
Addition & Attrition
Spring 'break' this week, so only 12 companies added, five removed. Summary on the downloads page.
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AstraZeneca
Their vaccine has been under fire in Europe with some countries having suspended its use out of fear of blood clots amongst recipients. There were previously issues with their first clinical trial results, including administering the wrong dose to some patients. But hey, why stop there?
This week they released updated trial results based on their US data, which were better than any trial results they had shown before. Almost immediately, the independent Data & Safety Monitoring Board overseeing the trial informed the NIAID it was concerned these results were outdated and inaccurate. AZ followed up and said they would publish the full results shortly, which they did today.
They could have avoided all this by waiting two more days to publish all the results. Ridiculous. Not often you see a good Twitter meme about the drug industry, but one targeting this whole AstraZeneca traveshamockery was solid.
Frequency Therapeutics
A clinical trial for their hearing loss drug was set up with various dosing regimens. Patients received four administrations per week - either 0,1,2 or 4 doses of the actual drug with the remaining doses being placebo. All dosing regimens concluded the same thing - the drug didn't work.
Not that publicly-traded biotech companies are discouraged by such things...Frequency will continue on with their separate single-dose clinical trial.
Nascent Surgical
This company offers an aerosol tent intended to isolate patients in hospital beds. Wow, just look how comfortable and cozy grandma looks here. Maybe get one for home too.
Team Roast
Greywolf Therapeutics went with a color theme for their management team's attire. Since they have an actual color in their company name, I'm sure you've figured out they did not go with grey. But what's even better is they all wore the same shirt. To their credit they mixed it up and the four people opted for 1, 1, 2 & an unknown number of buttons left open. One picture leaves us guessing just how low that shirt gap goes...
Acuity Spatial Genomics
By their own account, this company is working on "Spatial 3D Genomics". Glad they clarified that the three dimensions they were working on were the spatial ones. Wouldn't want anyone to think they were working on length/height/time genomics.
$noo
If you have a baby and an extra $1400 hanging around, you can now buy a smart bassinet that plays white noise and rocks your baby all night. The company says most babies using their Snoo product "sleep 9 hours or more by 2-3 mos". That might sound amazing to a bleary-eyed parent, but in fact most babies sleep 6-8 hours at night by about 3 months. (Cue the limitless fury of parents whose babies did not sleep that much by 12 months).
$1400 for a short-term use product seems steep, but if anyone is easily separated from their cash, it's new parents looking for more sleep.
Deep S**t
uBiome was a start-up doing direct-to-consumer poop testing. They shuttered last October after an FBI-raid over their insurance-billing practices. Their whole business model seems to have been to charge the consumer $89 then bill the customer's health insurance $2500 or so for services not requested.
Jessica Richman & Zachary Apte, the married founders & former co-CEOs are now being indicted for fraud. They're accused of misleading investors about the state of the business, among other things.
Shouldn't be too shocking. After all, Richman was featured in a "30 Most Important Women Under 30 In Tech" list in 2014 after lying about her age. She was 40 at the time. (Random fact: her middle name is Sunshine.)
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Head Like a Hole
More recently she founded a company called Beckley Psytech, which is also working to alter peoples' states of mind, but pharmaceutically this time. Guess the head-drilling business just couldn't get any VC money.
One Sweet Day
In what may be a March Fools' joke, Krispy Kreme is offering a free glazed donut every day to anyone showing their vaccine card. Bye bye Covid, hello diabetes!
Don't Believe in Time
Who would that help? If you want to contact someone across the world it's not the time on their clock that matters, it's what they're doing right now. With time zones, knowing what their clock says gives you information about what is occurring in that place right now. If it's 7:00 pm in Nairobi, people are likely eating dinner. With a universal clock, what information can most people in America glean from knowing it's 21:00 UTC in Mumbai?
The more interesting question here is whether time even exists, or whether it's just a way for people to measure entropy/things happening. Most physicists would have you believe it does exist, others are not as convinced. Considering time has long been shown to be relative, it's fair to wonder if it's simply a useful tool humans have created.
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Featured Job
Studylog - Trainer (Application Scientist) - Pacifica, CA
Studylog is looking for a Trainer (Application Scientist) with a passion for animal research and training to instruct users of our world-class software. In this position you will represent the standards and quality of Studylog Systems, Inc. when training new users on Studylog software remotely and in labs and offices around the world. Join our small team making world-class software! Opening requires that you are familiar with Studylog's software.
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ETC.
For Sushi's Sake
A restaurant chain in Taiwan ran a two-day promotion offering all-you-can-eat sushi to anyone whose name contained the character for salmon. Predictably, over 150 people legally changed their names, sparking the government to request that they please not do that anymore. The Deputy Interior Minister stated: “I hope everyone can be more rational about it”.
What could be more rational than name-change sushi arbitrage? If you don't want people to randomly change their name for a sushi sale, charge more for a name change, dude.
One person even decided to tack on "abalone", "crab" and "lobster" to his new name for good measure, presumably to take advantage of possible future promotions. Kudos to you, young man. Now head on over to Krispy Kreme for dessert.
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