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The RNA Transcript, January 23rd 2023

HMS Initiative for RNA Medicine Seminar

RNA "mutations" in Cancer: Are they Silent?

Polly Leilei CHEN, Ph.D. Principal Investigator & Associate Professor

Cancer Science Institute of Singapore

National University of Singapore


Tuesday January 24, 2023

10:00 - 11:00 a.m.

Zoom

Biophysics Seminar

Heterogeneous Structure (and other) of Disordered FUS Condensation

Sapun Parekh, Ph.D. Assistant Professor

Molecular, Cellular & Tissue Biomechanics

The University of Texas at Austin


Friday January 27, 2023

12:00 - 1:30 p.m.

1640 Chem, Zoom (link to follow)

U-M RNA Innovation Seminar

"Role of Circular RNA in Alzheimer's Disease"

Carlos Curchaga, Ph.D.

Director, NeuroGenomics & Informatics Center

Washington University in St. Louis


January 30, 2023

4:00 - 5:00 p.m.

BSRB, ABC Seminar Rooms, Zoom

RNA Collaborative Seminar Host: University of Science & Technology of China

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USTC Complex & UAD-2 Regulate piRNA Transcription in C. elegans

Speaker: Chengming Zhu, Ph.D.

Associate Professor


Exportin 4 in the Nuclear Export of Exonic circRNAs

Speaker: Liang Chen, Ph.D.

Associate Professor


Moderator: Shouhong Guang, Ph.D.


Wednesday, February 1, 2023.

10:00 am.

Zoom.

Chemistry Seminar

Talk Title TBA

Hanadi Sleiman, Ph.D.

Professor Chemistry & Canada Research Chair in DNA Nanoscience

McGill University


Tuesday February 7, 2023

4:00 - 5:30 p.m.

1640 Chem

U-M RNA Innovation Seminar

Why did the RNA Cross the Nanotube? Many questions and (some) answers on tuelling-nantoube medicated RNA transfer between mammalian cells

Gal Haimovich, Ph.D.

Assistant Staff Scientist

Department of Molecular Genetics

Weizmann Institute of Science


Monday, February 13, 2023

12:00 - 1:00 p.m.

Virtual Only, Zoom

News

2023 RNA Institute Annual Symposium (UAlbany & University of Rochester Center for RNA Biology)

The 2023 RNA Institute Symposium will be held March 16th-17th at the University at Albany, in collaboration with the University of Rochester Center Center for RNA Biology.


Links to event details and registration below.


There is a virtual attendee option. Virtual Participant fee: $20.


Abstracts and early-bird registration deadline: February 3rd.


Dates: Thursday, March 16 & Friday 17, 2023.

Venue: University at Albany, 1400 Washington Ave, Albany NY 12222.

U-M Medical School

The Research Operations, Management & Strategy (ROMS) Fellowship Application


The ROMS Fellowship is a two-year, paid, full-time position at the U-M Medical School designed to transition biomedical trainees from the bench to careers in research operations and administration through a series of unit rotations, hands-on learning experiences, and direct mentorship from leaders in the field.


The application will be open January 1 – February 19, 2023. 


Any additional questions can be addressed to ROMS.Fellowship@umich.edu 

6th International Course on "Post-transcriptional Gene Regulation: From Mechanisms to RNA Chemistry & Therapeutics"

The 6th international course on “Post-transcriptional gene regulation: from mechanisms to RNA chemistry and therapeutics" will take place on 24-28 April 2023 at Institut Curie in Orsay (Paris area, France).


We would greatly appreciate if you could transfer this information to your team and colleagues.


For more information, please visit the course webpage: https://training.institut-curie.org/courses/post-transcriptional-gene-regulation-2.


Deadline to register: February 17th


Registration is free but mandatory HERE.


Audience: Master and PhD students coming from European laboratories.


Candidates are selected based on their CV & a letter of motivation (mentioning the research theme and the authorization from the PI).


We would greatly appreciate if you could transfer this information to your team and colleagues.

Postdoctoral & Research Associate Positions in Microbiology & Systems Biology

The Jiang Lab (www.jianglab.org) at Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York invites applications for Postdoctoral Research Scientist and Research Associate positions in microbiology, microbial engineering and systems biology. We welcome individuals with experimental and/or computational backgrounds to apply. Candidates with specialties in antimicrobial resistance, single-cell RNA-sequencing, CRISPR and various systems biology approaches are highly sought after. To apply, please send your CV and the names and contact details of two or three references to wenyanjianglab@gmail.com

  

Over the last decade, the PI (Dr. Wenyan Jiang) developed revolutionary technologies that enhance the precision, throughput and resolution for bacterial genomics and transcriptomics. These include development of the very first CRISPR-Cas9 genome editing (Nature Biotech 2013, >2,000 citation) and gene expression modulation technology (Nucleic Acids Research 2013, >1,000 citation) in bacteria; a high-throughput bacterial functional genomics platform called CALM (Cell 2020); and the first bacterial high-throughput single-cell RNA sequencing (scRNA-seq) technology called PETRI-seq (Nature Microbiol 2020). Using these technologies, Jiang lab aims to study microbiology at a systems-level, such as understanding bacterial genetic architecture, evolution, single-cell behaviors, microbe-phage, and host-microbe interactions. The fundamental principles we learn from these studies could help us develop more effective antimicrobial drugs, and engineer commensal bacteria to promote human health.

SAVE THE DATE University of Michigan Center for RNA Biomedicine's 7th Annual RNA Symposium. March 24th, 2023

2023 Symposium

7th Annual RNA Symposium, “Title TBA”

Friday, March 24, 2022, 8:30am – 4:00pm

A. Alfred Taubman Biomedical Science Research Bldg, Kahn Auditorium

109 Zina Pitcher Pl, Ann Arbor, Michigan



Keynote Speakers:

Steve Henikoff, PhD, Talk Title TBA

Fred Hutchinson Cancer Research Center

Professor, Howard Hughes Medical Institute Investigator


Jody Puglisi, PhD, Talk Title TBA

Stanford University

Professor, Department of Structural Biology

Director, Stanford Magnetic Resonance Laboratory


Geraldine Seydoux, PhD, Talk Title TBA

Johns Hopkins University

Huntington Sheldon Professor in Medical Discovery

Professor of Molecular Biology & Genetics


Amy Gladfelter, PhD, The RNA Code in Condensates

University of North Carolina at Chapel Hill

Associate Professor of Biology


Joe Wedekin, PhD, Talk Title TBA

University of Rochester, Medical School

Professor of Biochemistry & Biophysics


More details of the day's agenda will be available in February

Our members' publications are available through Altmetrics. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation.


Below are recent highlights.

Nemudraia, A., Nemudryi, A., Buyukyoruk, M., Scherffius, A. M., Zahl, T., Wiegand, T., Pandey, S., Nichols, J. E., Hall, L., McVey, A., Lee, H. H., Wilkinson, R. A., Snyder, L. R., Jones, J. D., Koutmou, K. S., Santiago-Frangos, A., & Wiedenheft, B. (2022). Sequence-specific capture and concentration of viral RNA by type III CRISPR system enhances diagnostic. Research square, rs.3.rs-1466718. https://doi.org/10.21203/rs.3.rs-1466718/v1 https://www.nature.com/articles/s41467-022-35445-5

Watts, J. A., Grunseich, C., Rodriguez, Y., Liu, Y., Li, D., Burdick, J. T., Bruzel, A., Crouch, R. J., Mahley, R. W., Wilson, S. H., & Cheung, V. G. (2022). A common transcriptional mechanism involving R-loop and RNA abasic site regulates an enhancer RNA of APOE. Nucleic acids research, 50(21), 12497–12514. https://doi.org/10.1093/nar/gkac1107. doi.org/10.1016/j.jmb.2022.167688

To share your news and comments, please contact rna-communications@umich.edu

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