Something the Lord Made tells the story of the 34-year partnership that begins in Depression Era Nashville in 1930 when Blalock (Alan Rickman) hires Thomas (Mos Def) as an assistant at his Vanderbilt University lab, expecting him to perform janitorial work. But Thomas’ remarkable manual dexterity and intellectual acumen confound Blalock’s expectations, and Thomas rapidly becomes indispensable as a research partner to Blalock in his forays into heart surgery.