The RNA Transcript, November 14, 2022

U-M Department of Chemistry Gomberg Lecture

Divergent Roles of Dicer’s Helicase Domain in Antiviral Defense Brenda Bass, University of Utah

Monday, November 14, 2022

4:00 - 5:00 p.m.

Chemistry 1640

U-M Medical School

The Research Operations, Management & Strategy (ROMS) Fellowship Virtual Information Session

Monday, November 14, 2022

1:00 - 2:00 p.m.

event details and registration

U-M Michigan Institute for Data Science (MIDAS)

Annual Data Science and AI Summit

Kick-off of The Eric and Wendy Schmidt AI in Science program, with faculty vision talks and data science showcase

November 14-15, 2022

Rackham Building

event details and registration

U-M Oral Dissertation

The Molecular Basis of Improbable Enzymatic Chemistries

Meredith Purchal, Advisors: M. Koutmos & K. Koutmou

Tuesday, November 15, 2022

9:00 - 10:00 a.m.

Chemistry 1706

Harvard Initiative for RNA Medicine

RNA Delivery for Cancer Immunotherapy and Beyond

Jinjun Shi, Brigham and Women’s Hospital,Harvard Medical School

Tuesday, November 15, 2022

3:00 - 4:00 p.m.

event details and registration

U-M Oral Dissertation

Elucidation of DNA-Binding and Dimerization Activities of the Master Virulence Transcription Factor, VIRF, From Shigella Flexneri to Aid in Virulence-Targeted Inhibitor Design for Treatment of Shigellosis

Garrett Dow, Advisor: George Garcia

Wednesday, November 16, 2022

1:15 - 2:15 p.m.

Zoom meeting ID: 920 3024 8793, Passcode: 248732

RNA Collaborative Seminar host: RNA Institute, University At Albany

U-M RNA Innovation Seminar Series

RNA:DNA hybrids cause genome instability through nucleobase deamination, genomic rearrangements, and induction of the DNA damage response

Jeremy Schroeder, Biological Chemistry

Monday, November 21, 2022

4:00 - 5:00 p.m.

BSRB, ABC room with zoom option

U-M RNA Therapeutics Special Event

RNA as medicine

Melissa Moore, Moderna Therapeutics

Dr. Moore will be awarded an honorary degree at the University of Michigan Ann Arbor campus’ 2022 Winter Commencement and give this scientific talk to our RNA community.

Monday, December 19, 2022

12:00 - 1:00 p.m.

BSRB, Kahn Auditorium

Our members' publications are available through Altmetrics. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation.

Below are recent highlights.

McLean, E. K., Nye, T. M., Lowder, F. C., & Simmons, L. A. (2022). The Impact of RNA-DNA Hybrids on Genome Integrity in Bacteria. Annual review of microbiology, 76, 461–480. doi.org/10.1146/annurev-micro-102521-014450

Perera, B., Morgan, R. K., Polemi, K. M., Sala-Hamrick, K. E., Svoboda, L. K., & Dolinoy, D. C. (2022). PIWI-Interacting RNA (piRNA) and Epigenetic Editing in Environmental Health Sciences. Current environmental health reports, Advance online publication. doi.org/10.1007/s40572-022-00372-6

Grayeski, P. J., Weidmann, C. A., Kumar, J., Lackey, L., Mustoe, A. M., Busan, S., Laederach, A., & Weeks, K. M. (2022). Global 5'-UTR RNA structure regulates translation of a SERPINA1 mRNA. Nucleic acids research, 50(17), 9689–9704. doi.org/10.1093/nar/gkac739

Magnuson, B., Bedi, K., Narayanan, I. V., Bartkowiak, B., Blinkiewicz, H., Paulsen, M. T., Greenleaf, A., & Ljungman, M. (2022). CDK12 regulates co-transcriptional splicing and RNA turnover in human cells. iScience, 25(9), 105030. doi.org/10.1016/j.isci.2022.105030

Pham, V. V., Gao, M., Meagher, J. L., Smith, J. L., & D'Souza, V. M. (2022). A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA. Communications biology, 5(1), 819. pubmed.ncbi.nlm.nih.gov/35970937

Liu, Y., Munsayac, A., Hall, I., & Keane, S. C. (2022). Solution Structure of NPSL2, A Regulatory Element in the oncomiR-1 RNA. Journal of molecular biology, 167688. Advance online publication. doi.org/10.1016/j.jmb.2022.167688