DOTE Volume 34, Issue 8 | Editor's Choice
Free Article
Variation in the approach, radicality, and quality of gastroesophageal surgery impacts patient outcomes. Pathological outcomes such as lymph node yield are routinely used as surrogate markers of surgical quality, but are subject to significant variations in histopathological evaluation and reporting. A multi-society consensus group was convened to develop evidence-based recommendations for the standardized assessment of gastroesophageal cancer specimens.
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DOTE Volume 34, Issue 8 | Editor's Choice
Free Article
In complex systems standardization prevents avoidable unintended deviations and specifically reduces error rates. In the health system there seems to be gap between rigid standardization with all its positive merits and the actual executed standardization. Standardization is regarded as the key aim in quality assurance but it is still very subjective how to reach it.
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DOTE Volume 34, Issue 8 | Editor's Choice
Free Article
Oesophageal cancer is the sixth commonest cause of overall cancer mortality. Clinical staging utilizes multiple imaging modalities to guide treatment and prognostication. T2N0 oesophageal cancer is a treatment threshold for neoadjuvant therapy. Data on accuracy of current clinical staging tests for this disease subgroup are conflicting.
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DOTE Volume 34, Issue 8 | Quick Shot Review
Members-Only Article
Achalasia is a rare primary motor dysfunction of the esophagus without cure. Treatment for achalasia include surgery, pneumatic dilation or per-oral endoscopic myotomy (POEM). About 10-15% of patients with achalasia will eventually develop end-stage sigmoid shaped mega esophagus. This adds treatment complexity. Multiple guidelines have recommended esophagectomy as treatment for these patients, however, esophagectomy is associated with high morbidity and mortality (0-5.4%, 19-50%). In this article, systematic review and meta-analysis, the safety and efficacy of the Heller myotomy as first line in the treatment of sigmoid megaesophagus was evaluated. This study included 16 articles, a total of 350 patients (36 to 61 years old, 74 laparotomy and 276 laparoscopy). The success rate was 0.762 (CI: 0.703–0.812), reintervention rate was 0.128 (CI: 0.031–0.409), postoperative complications rate was 0.080 (CI: 0.040–0.153) and postoperative mortality was 0.008 (CI: 0.004–0.015). These findings are comparable to prior studies; however, this study did not find direct comparative outcomes of myotomy vs esophagectomy or any comparisons with the POEM technique.
In the March 2021 issue, Qiu, S et al, evaluated safety and efficacy of treating advanced achalasia (esophagus >/= 6 cm) using the POEM technique. A total of 112 patients were included. The technical success rate was 99.1% (median tunnel length 12cm, 7cm myotomy) and the clinical success rate was 93.1% (median follow-up 31 month), 8.9% post-procedure adverse events. There was no mortality. Our institution also recently successfully performed POEM for patient with end-stage mega esophagus (type 1 achalasia) with excellent clinical outcome.
Although the current literature using POEM in the treatment of advanced end-stage achalasia is scarce; however, with increasing acceptance of POEM, future studies directly comparing POEM vs surgery in the treatment of advance end-stage achalasia will continue to provide valuable insight.
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