Message from the Associate Dean - BCH Oakland
May 2020
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Who Are Our Heroes?
Who are our heroes? Are they the frontline healthcare workers traveling on full flights to help those in New York and the Navajo Nation- exhausted and energized only by their oath and the clanging of pans every evening? Are they the physicians and staff grounded at home who now have to teach school to their young children in between telehealth visits? Are they the educators who put all content on line in a matter of weeks? Are they the researchers who tested tests and sequenced proteins en route to a vaccine?
We no longer have singular heroes. Medicine is now a team sport. The real heroes have humbly collaborated with peers and got the work done to transform all aspects of the mission at record speed: clinical care, education, research and advocacy. A neighbor that I grew up with asked me in March how to get a serology test validated at UCSF and that happened. Another neighbor told me she was waiting for specimens at the state lab and we joked about a saliva test and now that is happening. Science is happening during porch visits. Education is happening in dining rooms. Advocacy is happening on social media and that is not a surprise. Advocacy got us a decent supply of food and PPE.
Our patients are certainly our heroes. They agreed to innovate first with a Zoom app that asks them to get their temperature taken by their parent and stand on the bathroom scale to be roomed. They agree to let me into their living rooms and meet their dog. They agree to show me where it hurts over video. They finally agree at the end of the visit to get exactly thirty minutes of safe exercise every day and even some will meditate - just so they do not go mad. The world will never be the same.
None of us will become heroically famous for the connections made. Heroes now rise up with a clever idea for the cause and asked to be connected and the work gets done. Public health and elected officials ask us how they can be of service in our community and vet their plans on endless calls, honing them to flatten the curve. Global health becomes local.
This past Monday I delivered flowers to my mother and tapped on her window, but eventually opted for a FaceTime visit. Our granddaughter met us at the rose garden safely in a socially distanced pack with masked parents. The sky was blue and the air clear, as best I could tell through my own mask. It was hard to actually smell the roses. But they were there in all their glory as they have been for generations. Look how much our world has changed in four weeks - let alone four generations. Where will we be in the next four weeks or four months? You are my hero as you answer that.
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Essential Workers Searching for Child Care
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If you are an essential worker,
Bananas
has valuable resources to help you find child care.
This information was obtained from Bananasbunch.org
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Congratulations to Our AAP-CA1 CATCH Grant Recipients!
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Residents Receive AAP CATCH
(Community Access to Child Health) Grants!
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Video Based Bridges to ABA (Autism Spectrum Disorders)
Maya Raman, MD, PL-2 and Clarissa Camarillo, MD, PL-2
The prevalence of Autism Spectrum Disorder (ASD) has increased to one in 59 children in the United States. Applied Behavioral Analysis (ABA) therapy has been proven to be effective for children with ASD, however it is difficult to access. Families in the Bay Area typically experience a 3-6 month delay from referral to the time initial ABA assessment is completed. There is often additional delay of weeks to several months until providers begin working with the patient.
Our project aims to support families waiting for access to ABA by demonstrating hands-on strategies for implementing behavioral interventions.
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The VOICE Project
Stephanie Y. Fong Gomez, MD, MS, PL-2 and
Noor Chadha, MS2
Pediatric medical homes have a powerful, underutilized opportunity to promote civic engagement among adolescents and families, resulting in healthier patients and communities. Emerging evidence shows that voting early in life is associated with healthier behaviors, positive mental health outcomes, and economic benefits over the life course. However, young people, low-income people, and people of color face structural, psychological, and logistical barriers to voting.
If you would like more information or are interested in incorporating voter engagement at your clinic, contact
stephanie.fonggomez@ucsf.edu
.
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Addressing Social Health and Early Childhood Wellness (ASHEW) Learning Collaborative
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The California Chapter 1, American Academy of Pediatrics
was awarded a grant to join the Addressing Social Health and Early Childhood Wellness (ASHEW) Learning Collaborative. The chapter leaders for this project are
Dr. Dayna Long
and
Dr. Gena Lewis
, though they will have a team to support them. Look for practice enrollment information in June with the project to begin in July.
Congratulations!
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Pediatric Diversity, Equity & Inclusion Catalysts
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From Jyothi Marbin MD
Associate Residency Program Director, Recruitment & DEI
Associate Clinical Professor, Department of Pediatrics
Director, HEAR Justice (Health Equity and Racial Justice) GME Pathway
University of California, San Francisco
Dear Pediatric Faculty,
Please consider applying to be a
Pediatric Diversity, Equity & Inclusion Catalyst
for the 2020-21 academic year, and be part of a new program funded by a grant from the UCSF BCH-SF Presidential Innovation Fund to promote Diversity, Equity and Inclusion across all of our clinical sites.
We are seeking 10-15 faculty members to actively work towards creating a more inclusive and equitable environment for our faculty, staff, trainees and patients. Our goal is to help faculty develop skills to lead conversations and serve as a resource to other faculty and learners as we increase the emphasis on diversity, equity and inclusion in our clinical environments. Members of this cohort will participate in targeted faculty development offerings to prepare them to lead and support discussions on making our learning climate more inclusive over the course of the 2020-21 academic year.
Total anticipated time commitment is 4-6 hours per month. Participating faculty will be recognized by the Department of Pediatrics as Pediatric Diversity, Equity & Inclusion Catalysts, be part of a community of practice, and have opportunities to get MOC credit and participate in scholarship.
We are seeking a diverse group of faculty from across our clinical sites. If you are interested in joining this exciting new initiative, please fill out
this interest form
by 6/1/20. Anyone is welcome to apply!
You can also nominate faculty members by emailing me directly.
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Office of Sustainability Giveaway
Office of Sustainability is giving away (1) Rainbow Grocery gift card or (1) Farm Fresh to You produce box (both valued at $35). This gift was generously donated by a winner in the Earth Day Challenge.
To enter the random gift drawing, please fill out the form below.
All frontline workers at UCSF campus and medical center are eligible.
Deadline to submit is
May 22nd
.
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UCSF Presents: Conversations on Children's Health 2020
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Wednesday, May 27, 2020
1:00 — 2:00 PM Virtual Event
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05.19.2020
Objectives:
Explain the influence of socioeconomic factors on health both at the neighborhood and individual level. (Holmen) Identify the impact of neighborhood-level poverty on the incidence of RSV-associated hospitalization. (Holmen) Recognize the relationship between severe RSV disease (as defined as need for ICU admission or death) and neighborhood-level poverty. (Holmen) AND Recognize the clinical presentation and natural history of pediatric diffuse midline glioma. (Coleman-Abadi) Assess the curre...
(link to more info)
Objectives:
1. Explain the influence of socioeconomic factors on health both at the neighborhood and individual level. (Holmen)
2. Identify the impact of neighborhood-level poverty on the incidence of RSV-associated hospitalization. (Holmen)
3. Recognize the relationship between severe RSV disease (as defined as need for ICU admission or death) and neighborhood-level poverty. (Holmen)
AND
1. Recognize the clinical presentation and natural history of pediatric diffuse midline glioma. (Coleman-Abadi)
2. Assess the current treatment standards for diffuse midline glioma. (Coleman-Abadi)
3. Identify the challenges in studying diffuse midline glioma and describe some novel therapies being investigated in the treatment of diffuse midline glioma including ONC201. (Coleman-Abadi)
05.26.2020
Objectives
:
Recognize the role of diet in pathogenesis of Inflammatory Bowel Disease (IBD). Compare popular dietary interventions and identify their benefits for patients with IBD. Identify when exclusive enteral nutrition is appropriate for patients with Crohn’s Disease.
(link to more info)
Grand Rounds is by Zoom only 8-9 am
Please follow the instructions below
https://ucsf.zoom.us/webinar/register/WN_dc2luv6gRwihqfgz40aLzw
Meeting ID:
952 8044 6125
Password:
246806
(dial in numbers will appear after one-time registration.)
UCSF Benioff Children’s Hospital Oakland is accredited by the California Medical Association
to provide continuing medical education for physicians.
UCSF Benioff Children’s Hospital Oakland designates this live activity for a maximum of
1 AMA PRA Category 1 Credit.™
Physicians should claim only the credit commensurate with the extent of their
participation in the activity.
Previous Grand Rounds (Online)
Did you miss Grand Rounds?
Use password
CHRCO
New recordings are added every few weeks.
Also check out our calendar for educational offerings:
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Here are some wellness resources, compliments of our colleagues at ZSFG, to encourage and strengthen you and your loved ones as we navigate the challenges in responding to COVID-19.
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(
Free subscription requires a NPI# and email address)
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Previously from Ted Chaconas, MD
Chief Medical Officer, BCH Oakland
Broken Places
In case you missed it...
Peabody Award-winning producer/director Roger Weisberg’s new documentary
Broken Places
explores the devastating impact of childhood trauma and stories of remarkable resilience. The film includes interviews with California Surgeon General
Dr. Nadine Burke Harris
, as well as BCH Medical Staff members
Dr. Tom Boyce
and
Dr. Dayna Long
. The program was presented by WNET’s multi-platform public media initiative Chasing the Dream: Poverty and Opportunity in America.
Watch it for free on
PBS
with a KQED Passport membership.
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Get Ready for UC Path - June 1st
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Get ready for UC Path – coming June 1. Here are quick steps you can take to prepare:
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Gradual Ramp Up of Research Begins May 18!
As was announced by Dr. Lindsey Criswell, Vice Chancellor of Research on May 14, we are pleased to share the much anticipated plans for gradually increasing activities in UCSF research units on campus. PIs and their research teams should review the detailed directives and safety information found in documents at the following links:
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UCSF Cross-Bay Collaborative Research Application
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From Mark Walters, MD
Professor of Pediatric Hematology/Oncology
Call for Applications
Research collaboration applications are now available for basic and translational laboratory scientists at UCSF and UCSF BCH Oakland who are committed to establishing collaborations with existing UCSF faculty in Oakland in the 5700 Martin Luther King, Jr. Way (MLK) building.
Details about the opportunity are attached in the RFA description.
Applications are due July 1, 2020
for awards up to $50,000 with funding that will commence on Sept 1, 2020.
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New Treatment Option for Transfusion-Dependent Beta Thalassemia
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From Mark Walters, MD
Professor of Pediatric Hematology/Oncology
New treatment option for transfusion-dependent
β-Thalassemia:
Beta thalassemia is the most common form of transfusion-dependent inherited anemia in the world. An imbalanced synthesis of globin chains constituting the hemoglobin molecule causes late-stage death of erythroid progenitors, which is driven by overactive signaling through activin receptor II. Luspatercept binds to ligands of activin receptor II in the extracellular compartment, and allows erythroblast maturation to proceed to red blood cells. As endogenous red cell production increases, the need for blood transfusion support is reduced.
A phase 3 multi-center clinical trial published in the New England Journal of Medicine demonstrated the efficacy of luspatercept in reducing transfusion burden in patients with thalassemia. The randomized controlled trial treated 336 adult patients with luspatercept or placebo for 48 weeks. Significantly more patients receiving luspatercept reduced their transfusion burden compared with those given placebo. Over any 24-week interval during the study, 41% of patients given luspatercept achieved >33% reduction and 17% achieved >50% reduction in transfusions.
Based on these results, luspatercept received FDA approval for use in patients 18 years of age or older with transfusion-dependent beta thalassemia. It is the first disease modifying therapy approved for thalassemia and represents a significant advance in the field, said Dr. Ashutosh Lal, an investigator on the clinical trial. The department of hematology/oncology has coordinated with BCHO pharmacy to assure the availability of luspatercept to all eligible patients. The drug is given as a subcutaneous injection every 3 weeks in the clinic or infusion center. Patients who respond to luspatercept can be transfused less frequently, thereby reducing the burden of treatment.
Cappellini, et al. A Phase 3 Trial of Luspatercept in Patients with Transfusion-Dependent β-Thalassemia. New England Journal of Medicine 2020;382:1219–31.
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Pediatric Research Day - May 21, 2020
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Internal COVID-19 Open Proposal Forum
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Open Proposal Forum
Gretchen Kiser
and the Research Development Office just launched an internal COVID-19 open proposal forum, asking researchers to share ideas, current research, and potential research avenues. The forum can be found online at:
This would be a good time to ask researchers to contribute their own ideas, and critically, to offer comments/suggestions to help improve the ideas that have already been proposed.
Some of the proposals involve communicating with the public, and it would be helpful if communicators could weigh in. For example, I just saw this citizen science proposal, which would let folks answer online surveys and (optionally) donate smartphone data to help researchers understand how COVID-19 is spreading or presenting to the public:
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NEW!
Transition of IRB Review for Research Conducted at UCSF Benioff Children’s Hospital Oakland
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Beginning May 1st, 2020, the UCSF HRPP will start receiving transfers of IRB approvals from UCSF Benioff Children’s Hospital Oakland (BCH Oakland) into the iRIS system.
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NEW!
Human Research Protections Program Updates
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Since the beginning of the COVID emergency, the Human Research Protections Program has made rapid adjustments to support the research community.
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Guidance for Researchers: COVID-19
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From Mark C. Walters, MD
Professor of Pediatrics
Interim Director of Research, UCSF BCH Oakland
Jordan Family Director, Blood and Marrow Transplant Program
Dear Clinical Research Community at BCHO:
This is to provide guidance about UCSF clinical research policies as these are being developed in response to the rapidly evolving COVID-19 pandemic. We would like to confirm and emphasize that all UCSF policies about research activities during the COVID-19 pandemic apply to the BCHO campus and to faculty and staff who work in Oakland. The best source of up-to-date information is located on the
UCSF COVID-19 website:
https://coronavirus.ucsf.edu/
There is a pull-down menu at the top of the website for Policies & Guidance, and at the bottom of the webpage, boxes with links for Researchers and Clinicians. Please become familiar with the policies restricting clinical trial enrollment and routine face-to-face clinic visits, study monitor visits, and travel related to clinical trial participation. All research activities should be restricted to visits and enrollments that are necessary to ensure patient safety.
In addition, please refer to the
IRB website
link regarding study protocol deviations and protocol changes with regard to COVID-19. Please feel free to contact the IRB administrator if you still have questions after reviewing the content of this website:
We appreciate the flexibility and cooperation in adhering to these new policies. Please do not hesitate to contact us if you have any questions about how your studies might be impacted.
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National Science Foundation on the Coronavirus Disease 2019 (COVID-19)
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FY20 DoD Pre-Announcements and Funding Opportunities
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Funding Opportunities
This is to notify the research community of recently released
Fiscal Year 2020 (FY20) pre-announcements and funding opportunities
for the Department of Defense (DoD) programs managed by the office of Congressionally Directed Medical Research Programs (CDMRP). CDMRP understands that applicants are impacted by COVID-19. Submission deadlines for pre-applications and full applications will incorporate the maximum time that is feasible for each FY20 program. Thank you for your efforts during this challenging time.
More info can be found
HERE
.
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Clinical Trials Office (CTO)
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Office of Clinical Trial Activation
OnCore at BCHO 2020 - For Research Study Teams
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Do you have ideas or suggestions for newsletter content?
If you have an idea or suggestion for content that you feel would be helpful,
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Benioff Children’s Hospital Oakland Dean’s Office
UCSF School of Medicine
510-428-3726
Mailing Address:
747 52nd Street, Oakland, CA 94609
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