Updates in Pediatrics
Editor: Jack Wolfsdorf, MD, FAAP

header with photos of various children
September 21, 2022 | Volume 13 | Issue 38
Blood-based brain injury biomarker concentrations with outcomes after pediatric cardiac arrest 
“Approximately 10,000 children experience in-hospital or out-of-hospital cardiac arrest annually in the US”. Of those that survive with return of spontaneous circulation, neurologic damage due to hypoxic-ischemic brain injury is common.

In small studies blood-based brain injury biomarkers (Glial fibrillary acid protein: GFAP; ubiquitin carboxyl terminal esterase L1: UCH-L1; neurofilament light: NfL) appear to be associated with neurological morbidity/mortality outcomes after pediatric cardiac arrest.

A multicenter prospective blinded cohort study (The Personalized Outcomes After Child Cardiac Arrest) which included 120 children (ages 48 hours – 17 years) who were resuscitated after cardiac arrest analyzed the association between blood-brain injury biomarkers concentrations and death/neurological outcomes at 1 year.


1 year after surviving a pediatric cardiac arrest 58.3% of children are alive with a favorable neurological outcome. Higher blood-based brain injury biomarkers, especially NfL are associated with unfavorable outcomes (primarily death). 
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