The RNA Transcript, April 17th 2023 | |
U-M RNA Innovation Seminar | |
RNA Collaborative Seminar | | |
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Unveiling the RNA Modification Landscape Through Bioanalytical and Biochemical Analyses
Joshua Jones, Advisors: R. Kennedy & K.Koutmou
Monday, April 17, 2023.
10:00 - 11:00 AM
Chem 1706
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Massively Parallel Screens to Identify Splice Disruptive Variants in Human Disease Genes
Cathy Smith, Advisors: J. Kitzman
Friday, April 21, 2023.
9:00 - 10:00 AM
MED SCI II 3813/3817
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Decoding Regulatory Variants With Computational Methods in Non-coding Regions of the Human Genome
Nanxiang Zhao, Advisors: A. Boyle
Monday, April 24, 2023.
10:00 - 11:00 AM
East Conference Room, Rackham
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Protein Phosphatase 2A Modulation Selectively Targets Cancer Cells by Activating Non-Canonical Pathways That Regulate Cell Fate in Response to Cellular Stress
Rita Avelar, Advisors: A. DiFeo
Monday, April 24, 2023.
1:30 - 2:30 PM
ABC Seminar Rooms, BSRB
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Lexogen RNA Expertise Blog Series | | |
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We are happy to introduce you to the LEXOGEN RNA EXPERTISE blog series, in which we will talk about various topics from the world of RNA and RNA-Seq, focusing on best practices, exciting applications, and more.
Inspired by the RNA journal's April 2023 special edition, we dedicate our newest blog post to RNA therapeutics.
RNA Therapeutics: The Future is Bright
RNA therapeutics are a rapidly expanding category of drugs based on RNA molecules aimed at treating or preventing diseases. Recent clinical success and primarily the breakthrough of a series of fast-tracked and effective messenger RNA (mRNA)-based vaccines helping to conquer the COVID-19 pandemic did not only make “RNA” a household name but also reignited and propelled research interest in RNA therapeutics.
This blog article will discuss the advantages of RNA therapeutics, concepts, and modes of action of different classes of RNA-based therapeutics. We will also give a glimpse into the RNA therapeutics currently being evaluated in clinical trials or having received approval.
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28th Annual Meeting of the RNA Society: May 30th thru June 4th | | |
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Abstract: “RNA therapeutics” refers to a disease treatment or drug that utilizes RNA as a component. In this context, RNA may be the direct target of a small-molecule drug or RNA itself may be the drug, designed to bind to a protein, or to mimic or target another RNA. RNA has gained attention in the drug-development world, as recent clinical successes and breakthrough technologies have revolutionized the drug-like qualities of the molecule or its usefulness as a drug target. In this special issue of RNA, we gathered expert perspectives on the past, present, and future of the field, to serve as a primer and also a challenge to the broad scientific community to incorporate RNA into their experimental design and problem-solving process, and to imagine and realize the potential of RNA as a therapeutic drug or target.
Michelle L. Hastings1 and Adrian R. Krainer2
Corresponding author: krainer@cshl.edu
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RNA Function Trainee Networking Event: May 17 2023 | | |
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The Center for RNA Biomedicine's Student and Postdoc Council is hosting the second annual RNA Function event on Wednesday, May 17 from 11 AM to 2 PM in the BSRB ABC Seminar Rooms.
This is a low-stress environment where we invite trainees of all levels who are interested in RNA biology to come together to make connections with other trainees from across the university. The event will include a casual poster session as well as facilitated networking, with lunch provided for registered participants.
Please register here by May 10. We are looking forward to seeing you there!
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Congratulation Jingxuan Tang - PPG Summer Research Fellowship Award | | |
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Jingxuan Tang has been selected as the department winner for the PPG Summer Research Fellowship Award.
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Biophysical Society - Postdoctoral Reviewer Program | | |
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Biophysical Journal is accepting applications from postdocs who are members of The Biophysical Society to be Postdoctoral Reviewers. Successful Applicants will be paired with an Editor of the journal working in your research area to receive guidance and mentorship in learning how to review articles submitted for consideration by the journal. This program will give postdocs the opportunity to engage with the editorial board of the Biophysical Society’s flagship journal and to learn how to provide a complete and useful review of a paper, an essential task that contributes to the biophysics community.
Applications are due by July 1, 2023 for selected individuals to begin reviewing in September 2023.
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2023 NCI RNA Biology Symposium: April 27 - 28 | | |
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RNA biology has emerged as one of the most influential areas in modern biology and biomedicine. The discovery of new classes of RNAs and their functions in a wide spectrum of biological processes has revolutionized molecular biology and has profound implications for clinical sciences. Key areas include the elucidation of RNA biogenesis and structure, the identification of functions for various classes of RNAs, the roles of RNA in disease and the emergence of RNA-based-and RNA-targeted therapies.
The symposium offers the opportunity to learn more about the current status of RNA biology in development and disease and share research with leading figures in the field and discuss the use and implications of these advances for clinical applications.
We hope you join us for the 2023 NCI RNA Biology symposium!
Registration is free but is required to attend. There will be no onsite registration.
For conference-related questions, please contact ccrconferences@mail.nih.gov.
April 27-28, 2023
National Institutes of Health 9000 Rockville Pike Bethesda, Maryland 20892
Building 45 Natcher Auditorium
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2023 RiboClub Annual Meeting: September 24 - 28 | | |
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The RiboClub Annual Meeting aims at encouraging the exchange of ideas and stimulates collaborations between RNA biologists around the world. The meeting covers different topics related to the chemistry, structure and biology of RNA with emphasis on upcoming and debatable biological questions. In addition, every year the RiboClub puts the focus on a local or regional RNA group to highlight their efforts and introduce them to the international community.
The meeting format provides principal investigators the opportunity to present their point of views on the current state of knowledge and ignite the curiosity of young scientists. The meeting size and its format give ample opportunity for discussions and interactions, so bring your thinking hat to uncover the next big idea.
Registration fees are subsidized to encourage the participation of students and upcoming researchers. All laboratory members are invited to attend, listen to the presentations of leading scientists and participate in poster competition.
Annual Meeting September 24-28, 2023
Chéribourg Hotel, Orford, Quebec, Canada
Register by: June 30th, 2023
More Inforamtion :www.riboclub.org
Questions: riboclub@riboclub.org
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Our members' publications are available through Altmetrics. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation.
Below are recent highlights.
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Mustoe AM, Weidmann CA, Weeks KM. Single-Molecule Correlated Chemical Probing: A Revolution in RNA Structure Analysis. Acc Chem Res. 2023 Apr 4;56(7):763-775. doi: 10.1021/acs.accounts.2c00782. Epub 2023 Mar 14. PMID: 36917683; PMCID: PMC10078950. https://pubs.acs.org/doi/10.1021/acs.accounts.2c00782 | |
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Mandal, S., Khanna, K., Johnson-Buck, A., & Walter, N. G. (2022). A guide to accelerated direct digital counting of single nucleic acid molecules by FRET-based intramolecular kinetic fingerprinting. Methods (San Diego, Calif.), 197, 63–73. Highlighted in NCI's Epidemiology & Genomics Research Program (EGRP) https://doi.org/10.1016/j.ymeth.2021.06.014
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Wang, E. T., Freudenreich, C. H., Gromak, N., Jain, A., Todd, P. K., & Nagai, Y. (2023). What repeat expansion disorders can teach us about the Central Dogma. Molecular cell, 83(3), 324–329. https://doi.org/10.1016/j.molcel.2022.12.017 | | | | |
