The Core Center for Musculoskeletal Biology & Medicine (CCMBM) defines itself by emphasizing musculoskeletal-specific education and services that are critical to its members but not available elsewhere in the university system | |
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The CCMBM leadership team is excited to announce that we have been awarded another five-year cycle for our P30 grant from NIH/NIAMS. This award supports continuation of the Core Center for Musculoskeletal Biology and Medicine (CCMBM) and the funding and services it provides to our musculoskeletal community. Thanks to your success and involvement, reviewers praised CCMBM for stimulating collaborative publications by 28%, increasing membership by 41%, and fostering a 2.4x increase in grant funding to CCMBM members.
The new P30 enables the CCMBM to continue supporting and growing a robust musculoskeletal research community at UCSF and throughout the UC system. In addition to core services, seminars and workshops, and funding for musculoskeletal research, new initiatives for this next funding cycle include expansion of computational and data science resources for CCMBM members and growth of the UC STRETCH program. Stay tuned for more. Cheers!
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Female athletes are up to 8 times more likely to sustain an ACL rupture compared to males. The goal of this study is to identify cellular and transcriptomic differences between male and female ACL tissue that may be an underlying cause of the higher ACL rupture rate in women.
The rate of ACL tears has increased significantly over the past several decades. One discrepancy not well understood is the differences in tear rate between sexes. Women have been found to experience tear rates that are 2-8 times higher than men. However, the statistically significant difference in terms of tear rate is lost between sex following ACL reconstruction (ACLR) suggesting an intrinsic difference between male and female ACL tissue. We hypothesized there is a biological sex difference in the composition of the ACL at the cellular and transcriptomic level that can help explain the increased ACL tear rate in females.
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Figure: Model of proposed human ACL heterogeneity and fibroblast subpopulations including a ligament progenitor 600 population (LPCs). There are sex based disparities in all ACL cell types as well as significant transcriptomic differences in 601 PDGFRα+/TPPP3+ LPCs. | | |
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Bethany Andoko
Junior Specialist
Department of Orthopaedic Surgery
Award: JIC Grant Development Award
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Verima Pereira, PhD
Postdoctoral Fellow
Department of Hematology and Oncology
Award: JIC Grant Development Award
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Betsy Young, MD
Instructor
Department of Pediatrics
Award: JIC Grant Development Award
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Charlotte Eaton, PhD
Postdoctoral Scholar
Neurosurgery
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Ashutosh Parajuli, PhD
Staff Research Associate III
Endocrine Research Unit, NICRE, SFVAMC
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Zachary Brumm
MD Candidate
School of Medicine
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Amrita Hans, MD
Fellow
Endocrinology & Metabolism
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In an effort to better collect an accurate list of CCMBM member publications, we are asking our members to please alert us to any submitted, accepted, or published manuscripts that either utilized CCMBM funding/core services or resulted from a collaboration with our membership.
Simply complete the our submission form and we will spotlight your publication in a future newsletter and on social media. We are excited to learn about your research!
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The UCSF Musculoskeletal Center convened summer students involved in musculoskeletal research for a lunch social at Genentech Hall on July 19th. High School and undergraduate students were in attendance from labs of Departments of Orthopaedic Surgery, Radiology & Biomedical Imaging, and Physical Therapy & Rehabilitation Science. The overall goal to hosting a summer student is to stimulate interest in health sciences for under-represented students and providing them with professional skills, hands-on research experience, and networking opportunities to improve their likelihood of success in STEM careers. Thank you to the faculty and student mentors who joined us to create a rewarding, networking opportunity for all our summer students! | |
We are excited to host the above upcoming seminars and bring speakers to the UCSF community this 2024-2025 academic year. CCMBM members, including junior investigators, trainees and learners, have priority to meet with visiting faculty speakers. The CCMBM Seminar Committee will provide scheduling details as we near each speaker’s visit. Contact Pui Yee Law if you would like us to consider and invite potential speakers to visit UCSF. | | |
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Submission deadline: September 30, 2024, 2:00pm PST
The Resource Allocation Program (RAP), an umbrella consortium of UCSF funders that coordinates multiple intramural research funding opportunities, is now accepting applications for the Fall 2024 Cycle. Review the grant-specific descriptions/instructions for the grant mechanism you are applying, not the funding agency. Funding agencies will select the awardees by choosing the proposals that best fulfill their programmatic goals. Simultaneous consideration of each application by multiple funding agencies enhances funding likelihood.
Grant Review sessions are available to allow investigators to strengthen their proposals for this cycle. Individuals will who sign up will receive 1:1 feedback and/or live panel review with peers as well as coaching from experienced investigators. The following dates are still available:
Thursday, September 5th, 8:30 am - Radiology
Tuesday, September 10th, 10:00 am - SFVAMC Endocrine Unit
Friday, September 13th, 10:00 am - CCMBM Bone Investigator Group
To have your proposal reviewed, please fill out our sign up form. Please apply as soon as possible to ensure that the committee has time to review your proposal prior to the session date.
Funding results will be available by December 2024. See CCMBM Funding Opportunities for the RFA.
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The Grant Development Award provides funding for a junior CCMBM member to host a meeting (e.g., lunch or dinner) with 1-3 UCSF faculty members who are outside of the trainee’s current lab to:
1) brainstorm/solicit informal feedback on a study idea or research direction
2) learn about the latest methods and techniques used in related fields
3) identify potential collaborators
4) promote inter-disciplinary MSK research
5) expand the trainee’s professional network
If you are not a member, you may concurrently apply for membership while your Grant Development application is being reviewed.
Apply via the online application form today! Contact Noah Bonnheim for questions on this funding opportunity.
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Letter of Intent Deadline: September 4, 2024 at 12:00PM PT
The Burroughs Wellcome Fund's CASI program supports the early career development of researchers who are dedicated to pursuing a career in academic research. The specific target group are researchers who have transitioned from graduate work in thephysical/mathematical/computational sciences or engineering into postdoctoral work in the biological sciences.
Proposals that include deep or machine learning applications of artificial intelligence are particularly encouraged. Special consideration will also be given to proposals that investigate theconnection between climate change and human health.
This program will provide $560,000 over five years to bridge advanced postdoctoral training and the first three years of faculty service.
If you're interested in applying, please email Liz Catalano to announce your intention. Afterwards, follow the application instructions in the RFP, conferring with your Grants Officer as needed.
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Application Deadline: September 18, 2024 & November 6, 2024
The NSF SBIR/STTR and SBIR/STTR Fast-Track pilot programs support moving scientific excellence and technological innovation from the lab to the market. By funding startups and small businesses, NSF helps build a strong national economy and stimulates the creation of novel products, services, and solutions in private, public, or government sectors with potential for broad impact; strengthens the role of small business in meeting federal research and development needs; increases the commercial application of federally supported research results; and develops and increases the US workforce, especially by fostering and encouraging participation by socially and economically disadvantaged and women-owned small businesses.
To learn more, view the program solicitation here.
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Application Deadline: September 30, 2024, 2:00pm PT
The Catalyst Program is UCSF’s translational accelerator focused on advancing UCSF discoveries with clinical impact and commercial potential. The centerpiece of the Catalyst Program are the Catalyst Awards (up to $100,000) that provide both industry advisor mentorship and seed funding to UCSF Principal Investigators (PIs) with promising translational projects. The Catalyst Awards are focused on the development of therapeutics, diagnostics, medical devices, digital health, and biotools. Projects that address important problems with high relevance to clinical or translational neuroscience and human health, that can lead to a tangible benefit to patients, are of special interest thanks to our partnership with the UCSF Weill Institute for Neurosciences. Projects focused on the human microbiome are also of special interest thanks to our partnership with the UCSF Benioff Center for Microbiome Medicine.
To learn more, view the RFA here.
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Application Deadline: October 1, 2024, at 5:00pm ET
The Pilot Award Program is a new component of our NIH-supported U42 program the Human Tissues and Organs for Research Resource (HTORR), and will support individuals that meet at least one of the following three high priority areas:
- Individuals from underrepresented populations in the U.S. biomedical workforce, including women, minorities, persons with disabilities and persons from disadvantaged backgrounds.
- Early-stage investigators that are within 10 years of a terminal degree or completion of clinical residency.
- Established investigators that are transitioning to use human biospecimens.
The 2-year awards provided through our Pilot Award Program will include up to ~10 biological samples per awarded investigator, covering all costs associated with obtaining the biospecimens, including tissue preservation reagents and shipping costs. Beyond the service period and experimental analysis phase, the awardee will also receive supplementary support to develop grant applications to the NIH Institute that supported their award, and only applications that fall into the fields covered by these institutes will be reviewed.
The institutions currently supporting the Pilot Award Program are:
- Office of Research Infrastructure Programs (ORIP)
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Heart, Lung, and Blood Institute (NHLBI)
- National Eye Institute (NEI)
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
To learn more, visit the HTORR website here.
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Application Deadline: October 14, 2024
The PIPE Interprofessional Clinical Opportunities Grant was created to support individual clinical sites in piloting new interprofessional immersive experiences for learners (students, residents and/or fellows) in the health professional programs at UCSF (Dentistry, Medicine, Nursing, Pharmacy, Physical Therapy). Selected proposals will receive one-time funding of $10,000 to create and pilot a new interprofessional immersive experience.
Learn more on the PIPE website, and direct any application-related questions to Wendy Brown.
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Application Deadline: November 19, 2024
This Notice of Funding Opportunity (NOFO) is designed to support highly integrated research teams to address challenging questions with the potential to significantly advance dental, oral and craniofacial (DOC) fields of research. Each project should have a unified and well-defined scientific goal within the NIDCR mission that requires a team with diverse perspectives and expertise in a variety of intellectual or technical areas and is beyond the experience and capabilities of one or two investigators. Teams are encouraged to consider transformative, and disruptive innovative objectives with defined 5-year outcomes/deliverables. This Notice of Funding Opportunity (NOFO) requires a Plan for Enhancing Diverse Perspectives (PEDP).
To learn more, view the NOFO here.
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Recognizing the need for collaboration of MSK scientists with experts outside of the MSK field, we are providing support to MSK Center members to host a meal for a creative and enjoyable in-person networking meeting to stimulate these interactions and to further develop new research ideas and plans to fund them. Faculty, staff, and trainees who are MSKC/CCMBM members are encouraged to apply to host an event.
If you are not a member, you may concurrently apply for membership while your Open MIKE application is being reviewed.
Apply via the online application form today! Contact Cristal Yee for questions on this funding opportunity.
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UCSF Talks is a new resource for anyone interested in learning about the latest seminars happening at UCSF. It lists all seminars open to the entire UCSF community including regular seminar series, special seminars, supergroups, and thesis talks. If you would like to receive weekly event listing emails, you can sign up for the USCF Talks Google Group. To add an event to the website, please contact Jon Zhang. | |
Core Center for Musculoskeletal Biology and Medicine (CCMBM), 513 Parnassus Avenue, S-1161, San Francisco, CA 94143 | | | | |
