The RNA Transcript, November 21, 2022

News

Please join us in welcoming Allison Kintz to the U-M Center for RNA Biomedicine!

Allison has been working in higher education for the past 10 years as an event coordinator/administrative assistant. and will join the RNA Center team as the Administrative Assistant.

U-M RNA Innovation Seminar

RNA:DNA hybrids cause genome instability through nucleobase deamination, genomic rearrangements, and induction of the DNA damage response

Jeremy Schroeder, Biological Chemistry

TODAY Monday, November 21, 2022

4:00 - 5:00 p.m.

BSRB, ABC room with zoom option

U-M Oral Dissertation

Structural and Functional Analysis of Human Dicer

Rachel Torrez, Advisors: A. Garner and M. Ohi

Tuesday, November 28, 2022

10:00 - 11:00 a.m.

LSI Library

RNA Collaborative Seminar host: Penn Institute for RNA Innovation

U-M Oral Dissertation

Biochemical and Structural Studies of the Outer Mitochondrial Membrane Protein, Miro1

Emily Eberhardt, Advisor: M. Cianfrocco

Friday, December 2, 2022

1:00 - 2:00 p.m.

BRSR, Kahn Auditorium

mRNA as Medicine: COVID-19 Vaccines and Beyond

Melissa Moore, Moderna Therapeutics

Dr. Moore will be awarded an honorary degree at the University of Michigan Ann Arbor campus’ 2022 Winter Commencement and give this scientific talk to our RNA community.

Monday, December 19, 2022

12:00 - 1:00 p.m.

BSRB, Kahn Auditorium

Our members' publications are available through Altmetrics. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation.

Below are recent highlights.

McLean, E. K., Nye, T. M., Lowder, F. C., & Simmons, L. A. (2022). The Impact of RNA-DNA Hybrids on Genome Integrity in Bacteria. Annual review of microbiology, 76, 461–480. doi.org/10.1146/annurev-micro-102521-014450

Perera, B., Morgan, R. K., Polemi, K. M., Sala-Hamrick, K. E., Svoboda, L. K., & Dolinoy, D. C. (2022). PIWI-Interacting RNA (piRNA) and Epigenetic Editing in Environmental Health Sciences. Current environmental health reports, Advance online publication. doi.org/10.1007/s40572-022-00372-6

Grayeski, P. J., Weidmann, C. A., Kumar, J., Lackey, L., Mustoe, A. M., Busan, S., Laederach, A., & Weeks, K. M. (2022). Global 5'-UTR RNA structure regulates translation of a SERPINA1 mRNA. Nucleic acids research, 50(17), 9689–9704. doi.org/10.1093/nar/gkac739

Magnuson, B., Bedi, K., Narayanan, I. V., Bartkowiak, B., Blinkiewicz, H., Paulsen, M. T., Greenleaf, A., & Ljungman, M. (2022). CDK12 regulates co-transcriptional splicing and RNA turnover in human cells. iScience, 25(9), 105030. doi.org/10.1016/j.isci.2022.105030

Pham, V. V., Gao, M., Meagher, J. L., Smith, J. L., & D'Souza, V. M. (2022). A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA. Communications biology, 5(1), 819. pubmed.ncbi.nlm.nih.gov/35970937

Liu, Y., Munsayac, A., Hall, I., & Keane, S. C. (2022). Solution Structure of NPSL2, A Regulatory Element in the oncomiR-1 RNA. Journal of molecular biology, 167688. Advance online publication. doi.org/10.1016/j.jmb.2022.167688