RNA Translated 2024
We are pleased to announce the publication of our latest issue of RNA Translated, the University of Michigan Center for RNA Biomedicine annual magazine and brief report. You can view an interactive, digital version of the magazine on our website and also download a pdf copy.
The 2024 issue focuses on our groundbreaking efforts to build a University of Michigan “M-RNA Therapeutics” initiative for “changing tomorrow’s world of medicine, today.”
We hope you find the magazine informative and engaging!
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RNA Innovation Seminar Series | Monday, April 1, 4:00-5:00 p.m. | | |
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“A stem cell approach to human genetics- from CRISPR screens in hPSCs to genes, enhancers and disease.”
Presented by:
Danwei Huangfu, Ph.D.
Professor and Member
Developmental Biology Program
Sloan Kettering Institute
Memorial Sloan Kettering Cancer Center
Today - Monday, March 25, 2024
11:00 AM – 12:00 PM EST
Kahn Auditorium, BSRB
Hosted by: Sundeep Kalantry, Ph.D.
Professor of Human Genetics
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U-M Department of Biological Chemistry Seminar | |
HMS Initiative for RNA Medicine - RNA Technology Showcases | |
RNA Collaborative Seminar Series | | |
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UNC-CH RNA Discovery Center
Speaker Alain Laederach, Ph.D., Professor, Department of Biology, UNC College of Arts and Sciences, Chapel Hill, NC, USA, “pre-mRNA structure change in controlling alternative splicing”
Speaker Mauro Calabrese, Ph.D., Associate Professor and Director of Graduate Studies, Department of Pharmacology, UNC School of Medicine, Chapel Hill, NC, USA, "Ectopically expressed Airn lncRNA recruits Polycomb to chromatin without inducing gene silencing"
Moderator: Chad Pecot, M.D., Associate Professor, Department of Cell Biology and Physiology, Lineberger Comprehensive Cancer Center, UNC School of Medicine, Chapel Hill, NC, USA
March 27, 2024, 10 AM ET
Zoom Registration
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From our sponsor: Lexogen RNA Expertise Blog Series | | |
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Single-cell RNA-Seq has revolutionized the field of transcriptomics, providing unprecedented insight into cellular complexity and heterogeneity. In our first blog post of the RNAEXPERTise Blog Series on Single-Cell RNA-Seq – “Classical Single-Cell RNA Sequencing: a comprehensive overview” – we talked about the basic principles, benefits, and most common applications of classical single-cell RNA-Seq.
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Santhi Ganesh, M.D., publishes results of study focusing on genetic drivers of blood pressure regulation in females | | |
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In a recent study, U-M Center for RNA Biomedicine faculty member Santhi Ganesh, M.D., and colleagues identified specific genetic drivers of blood pressure regulation in females. The results were published in an article in Nature Medicine, and hold significant implications for future development of therapeutic strategies.
"Sex-specific genetic architecture of blood pressure"
Nature Medicine, March 8, 2024, DOI: https://doi.org/10.1038/s41591-024-02858-2
Read the full article by Noah Fromson in Michigan Medicine's Health Lab.
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Eva Feldman, Stephen Goutman, and Stuart Batterman link hobbies and recreational activities such as golf to ALS development risk | | |
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Stephen Goutman, M.D., M.S. | |
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On March 21, 2024, the University Record reported on a Toronto Sun story about a recent ALS risk-factor study by a team of U-M scientists, including CRB faculty members Eva Feldman, Stephen Goutman, and Stuart Batterman, who found that golfing, gardening, and other recreational activities can increase the risk for Lou Gehrig’s disease due to exposure to pesticides and other chemicals.
"Avocational exposure associations with ALS risk, survival, and phenotype: A Michigan-based case-control study"
Journal of the Neurological Sciences, January 22, 2024, DOI: https://doi.org/10.1016/j.jns.2024.122899
See related story, “Stephen Goutman, Stuart Batterman, and Eva Feldman publish paper on blood test to assess ALS development risk”, The RNA Transcript, November 20, 2023.
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8th Annual Symposium Highlights | |
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Read the LIVE Tweets from MiSciWriters correspondents, once again on hand to capture all the stories. For a more in-depth look, check out their Blog posts written live during the event. Follow MiSciWriters' coverage on Twitter with the hashtag #UMichRNA.
Save the Date!
Thank you for joining us on Friday, March 8, and be sure to save the date for next year’s event: the 9th Annual RNA Symposium on March 6-7, 2025!
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In Case You Missed It ... | |
Kathleen Collins publishes findings from a recent study on HIV protein that could help pave way for cure | | |
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University of Michigan Center for RNA Biomedicine faculty member Kathleen Collins, M.D., Ph.D., and colleagues publish findings from recent study, helping to open a promising pathway for the development of a cure for HIV rather than just a treatment.
"Structure–Activity Relationships of Natural and Semisynthetic Plecomacrolides Suggest Distinct Pathways for HIV-1 Immune Evasion and Vacuolar ATPase-Dependent Lysosomal Acidification"
Journal of Medicinal Chemistry, March 7, 2024,
DOI: 10.1021/acs.jmedchem.3c01574
Read the full article in The University Record.
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Pedro Lowenstein develops new model of known brain tumor feature | | |
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Center for RNA Biomedicine faculty member Pedro Lowenstein, M.D., Ph.D., led a team in a recent study of onostreams, a key feature for glioblastoma development, and identified a potential inhibitor that appears to dismantle these aggressors.
"Spatiotemporal Insights into Glioma Oncostream Dynamics: Unraveling Formation, Stability, and Disassembly Pathways"
Published in Advanced Science, 22 February 2024 https://doi.org/10.1002/advs.202309796
Read the full story in Michigan Medicine's Health Lab
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"Structure and Targeting of Precursor MicroRNA-31: From Mechanism to Application"
Sicong Ma, Biophysics
Advisor: Sarah Keane
Wednesday, March 27, 2024
1:00 PM
EARL LEWIS ROOM (RACKHAM) & ZOOM
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"Biophysical Characterization of Polymorphic Amyloid and Lipid Aggregation Associated with Type 2 Diabetes"
Sam McCalpin, Chemistry
Advisors: Magda Ivanova and Sarah Keane
Tuesday, April 2, 2024
2:00 PM
CHEM 1706
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For more information and to view the full schedule of upcoming U-M Oral Defenses, please visit the Rackham Graduate School Oral Defenses website. | |
HIRM 2024 Symposium, April 25, 2024 - Registration Open! | | |
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2024 Symposium
HIRM 10 Year Anniversary Symposium
Thursday, April 25, 2024
Joseph B. Martin Conference Center
77 Avenue Louis Pasteur
Boston, MA 02115
Registration Open
Poster Submissions now closed.
For more information, contact Grace Lee at glee8@bidmc.harvard.edu
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RNA Society Annual Meeting May 28 - June 2, 2024 | |
6th Annual RNATx Umass June 26-28, 2024 | | |
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2024 RNATx Registration
From Concept to Clinic happening both in person and virtually, at the RNA Therapeutics Institute at UMass Chan Medical School
June 26 - June 28, 2024
We invite you to share your work with leading RNA Investigators by submitting your abstracts. We will be evaluating abstracts for a limited number of short talks, so submit yours early!
Oral Abstract submissions now closed.
Poster Abstract submissions now closed.
Early Registration Deadline: April 19, 2024
See abstract guidelines and tips for proper formatting and how to write your abstract.
Please see our symposium website for details and do not hesitate to contact us if you have any questions at RNATherapeutics@umassmed.edu.
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Gordon Conference on Post-transcriptional Gene Regulation July 14-19 | | |
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Check out the scientific program lined up for the July 14-19 Gordon Conference on Post-transcriptional Gene Regulation in beautiful Portland, ME! This year’s theme is The Versatility of RNA in the Living World. Attendance is limited, so we are trying to get the word out that interested folks should apply before March 15th for the best chance of availability. Trainees: see the associated Gordon Research Symposium as well!
For more information and registration, visit https://www.grc.org/post-transcriptional-gene-regulation-conference/2024/
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RiboClub 25th / RiboWest 20th / TREnD 8th Anniversary Celebration in Ottawa: RNA Canada 2024: The future of RNA technology | |
NEW!Non-coding RNA World 2024: Exploring Mechanisms, Designing Medicines | October 7-9, 2024 | | |
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Join us in Basel in October to learn about the latest developments in Non-Coding RNA research. Mingle with the world-leading invited speakers during ample networking opportunities. Present your research at poster sessions and numerous selected oral presentations. Discover the beautiful mediaeval city of Basel.
More details and abstract submission here: https://sciforum.net/event/ncRNA2024
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Our members' publications are available through Altmetric. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation.
Below are recent highlights.
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Feldstein LR, Britton A, Grant L, Wiegand R, Ruffin J, Babu TM, Briggs Hagen M, Burgess JL, Caban-Martinez AJ, Chu HY, Ellingson KD, Englund JA, Hegmann KT, Jeddy Z, Lauring AS, Lutrick K, Martin ET, Mathenge C, Meece J, Midgley CM, Monto AS, Newes-Adeyi G, Odame-Bamfo L, Olsho LEW, Phillips AL, Rai RP, Saydah S, Smith N, Steinhardt L, Tyner H, Vandermeer M, Vaughan M, Yoon SK, Gaglani M, Naleway AL. Effectiveness of Bivalent mRNA COVID-19 Vaccines in Preventing SARS-CoV-2 Infection in Children and Adolescents Aged 5 to 17 Years. JAMA. 2024 Feb 6;331(5):408-416. doi: 10.1001/jama.2023.27022. PMID: 38319331; PMCID: PMC10848053. | |
Tseng YJ, Krans A, Malik I, Deng X, Yildirim E, Ovunc S, Tank EMH, Jansen-West K, Kaufhold R, Gomez NB, Sher R, Petrucelli L, Barmada SJ, Todd PK. Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats. Nucleic Acids Res. 2024 Feb 27:gkae137. doi: 10.1093/nar/gkae137. Epub ahead of print. PMID: 38412259. | |
Wells AE, Wilson JJ, Heuer SE, Sears JD, Wei J, Pandey R, Costa MW, Kaczorowski CC, Roopenian DC, Chang CH, Carter GW. Transcriptome analysis reveals organ-specific effects of 2-deoxyglucose treatment in healthy mice. PLoS One. 2024 Mar 7;19(3):e0299595. doi: 10.1371/journal.pone.0299595. PMID: 38451972; PMCID: PMC10919611. | |
Taylor AS, Mannan R, Pantanowitz L, Chinnaiyan AM, Dhanasekaran SM, Hrycaj S, Cao X, Chan MP, Lucas D, Wang XM, Mehra R. Evaluation of TRIM63 RNA in situ hybridization (RNA-ISH) as a potential biomarker for alveolar soft-part sarcoma (ASPS). Med Oncol. 2024 Feb 23;41(3):76. doi: 10.1007/s12032-024-02305-9. PMID: 38393424; PMCID: PMC10891236. | |
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The Department of Molecular Genetics in the College of Arts and Sciences at The Ohio State University invites applications for the position of Ohio Eminent Scholar in Molecular Genetics, an endowed, tenure-track position at the Associate or Full Professor level. The Ohio Eminent Scholars (OES) Program, created by the Ohio General Assembly and administered by the Ohio Board of Regents, aims to enhance the national eminence of selected outstanding academic programs at Ohio universities by attracting internationally recognized scholars. Applications are sought from those with a distinguished track record of investigating fundamental biological questions in any system.
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University of Michigan BIBC Tenure Track Faculty Search - Deadline: Mar 31, 2024 at 11:59 PM EDT
The University of Michigan has launched a Tenure Track Faculty Search for the BioInnovations in Brain Cancer Initiative (BIBC), led by Center for RNA Biomedicine Faculty Member Dr. Maria G. Castro and Dr. Steven Schwendeman. Learn more.
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The University of California Irvine (UCI), Department of Ophthalmology Full-Time Position
Inviting applicants focused on the development of genetic engineering and genome editing technologies. Learn more.
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Postdoctoral Research Fellow and Graduate Research Assistants
Dr. Guizhi (Julian) Zhu Lab | University of Michigan
Multiple full-time openings for Postdoctoral Research Fellow and Graduate Research Assistants. Learn more.
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For complete details on current openings and how to apply for these positions, visit the Recruitment Opportunities page on our website | | | | |
