If there is tzoah on a person’s garment and it is covered, all opinions agree that a davar shebekedusha may be said. Nonetheless, a person should try to always wear clean clothing, especially for davening. Ideally, a person should wear special clothing for davening. In this way his davening will be akin to the Kohanim’s service in the Beis Hamikdosh, which was performed with special clothing.
ס"ק יב ו־טו; ביאורים ומוספים דרשו, 18
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