The RNA Transcript, November 7, 2022

U-M Pharmacology

TANGO (Targeted Augmentation of Nuclear Gene Output) to restore neuronal excitability of GABAergic interneurons of a mouse model of Dravet syndrome

Yukun Yuan, Associate Research Scientist, Isom Lab

Wednesday, November 9, 2022

3:00 - 4:00 p.m.

BSRB, ABC Seminar room

or via zoom (Zoom Meeting ID: 964 3975 5754, Passcode: 782364)

U-M Human Genetics

Gene Discovery and the Promise of Precision Medicine in Epilepsy Heather Mefford, St. Jude Children’s Research Hospital

Friday, November 11, 2022

12:00 - 2:30 p.m.

BSRB, Kahn Auditorium

U-M Medical School

ROMS Virtual Information Session

The Research Operations, Management & Strategy (ROMS) Fellowship is a two-year, paid, full-time position at the U-M Medical School designed to transition biomedical trainees from the bench to careers in research operations and administration through a series of unit rotations, hands-on learning experiences, and direct mentorship from leaders in the field.

Monday, November 14, 2022

1:00 - 2:00 p.m.

event details and registration

U-M Michigan Institute for Data Science (MIDAS)

Annual Data Science and AI Summit

Don't miss the kick-off of The Eric and Wendy Schmidt AI in Science program, with faculty vision talks, showcase of U-M data science and AI research organizations, and lots of networking opportunities!

November 14-15, 2022

Rackham Building

event details and registration

U-M Oral Dissertation

Elucidation of DNA-Binding and Dimerization Activities of the Master Virulence Transcription Factor, VIRF, From Shigella Flexneri to Aid in Virulence-Targeted Inhibitor Design for Treatment of Shigellosis

Garrett Dow, Advisor: George Garcia

November 16, 2022

1:15 - 2:15 p.m.

Zoom meeting ID: 920 3024 8793, Passcode: 248732

RNA Collaborative Seminar host: RNA Institute, University At Albany

Job Opportunities

Stephanie Moon Lab (U-M) seeking postdoc

to lead a project on molecular mechanisms of aging & neurodegeneration with state-of-the-art microscopy & RNA biology

APPLY HERE

Wilfried Rossoll Lab (Mayo Clinic) seeking postdoc

The Neurobiology of Neurodegenerative Diseases Laboratory at the Mayo Clinic in Jacksonville (FL) is looking for a highly motivated postdoctoral candidate for an NIH-funded study on the role of nuclear import receptors in reducing TDP-43 protein aggregation in amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) and other common neurodegenerative disorders such as Alzheimer’s disease (AD). APPLY HERE

Our members' publications are available through Altmetrics. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation.

Below are recent highlights.

Grayeski, P. J., Weidmann, C. A., Kumar, J., Lackey, L., Mustoe, A. M., Busan, S., Laederach, A., & Weeks, K. M. (2022). Global 5'-UTR RNA structure regulates translation of a SERPINA1 mRNA. Nucleic acids research, 50(17), 9689–9704. doi.org/10.1093/nar/gkac739

Magnuson, B., Bedi, K., Narayanan, I. V., Bartkowiak, B., Blinkiewicz, H., Paulsen, M. T., Greenleaf, A., & Ljungman, M. (2022). CDK12 regulates co-transcriptional splicing and RNA turnover in human cells. iScience, 25(9), 105030. doi.org/10.1016/j.isci.2022.105030

Pham, V. V., Gao, M., Meagher, J. L., Smith, J. L., & D'Souza, V. M. (2022). A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA. Communications biology, 5(1), 819. pubmed.ncbi.nlm.nih.gov/35970937

Liu, Y., Munsayac, A., Hall, I., & Keane, S. C. (2022). Solution Structure of NPSL2, A Regulatory Element in the oncomiR-1 RNA. Journal of molecular biology, 167688. Advance online publication. doi.org/10.1016/j.jmb.2022.167688