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Casein kinase 1 alpha (CK1α) is a member of a multi-isoform family of kinases that are involved in several processes in the brain, from Circadian rhythms and Wnt signaling to DNA repair and transcription and even fast synaptic transmission mediated by glutamate, the major excitatory neurotransmitter in the brain(1,2). It is also a major kinase responsible for the pathological hyperphosphorylation of tau protein in the paired helical filaments (PHFs) found in the brain tissue of AD patients(3).
Our antibody, derived from the smallest CKIα isotype, effectively interacts with all CKIα isotypes, exhibiting specificity exclusively for CKIα isoforms, including its four variations. It doesn't cross-react with other members of the CKI family, such as CKI beta, gamma, delta or epsilon proteins. This antibody is suitable for various application, including WB, ICC, IHC-Frozen.
References:
(1) Jiang, S., et al., Cell Commun Signal 16, 23 (2018), PMC5968562 (CK1 alpha review paper).
(2) Chergui, K. et al.,J Neurosci. 2005 Jul 13; 25(28): 6601–6609, PMC6725422 (glutamate fast transmission role ref)
(3) Kuret, J et al.,J Neurochem.1997 Dec;69(6):2506-15, PMID: 9375684 (PHF AD disease ref)
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