Keynote Speaker - Drew Weissman, M.D., Ph.D. | |
Drew Weissman delivering his Nobel Prize lecture at Aula Medica, Karolinska Institutet in Stockholm on 7 December 2023. © Nobel Prize Outreach. Photo: Nanaka Adachi. | |
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RNA Innovation Seminar Series
"Nucleoside Modified mRNA-LNP Therapeutics"
Drew Weissman, M.D., Ph.D.+
2023 Nobel Prize Laureate in Physiology or Medicine
Roberts Family Professor of Vaccine Research
Perelman School of Medicine
University of Pennsylvania
Abstract: Vaccines prevent 4-5 million deaths a year making them the principal tool of medical intervention worldwide. Nucleoside-modified mRNA was developed over 15 years ago and has become the darling of the COVID-19 pandemic with the first 2 FDA approved vaccines based on it. These vaccines show greater than 90% efficacy and outstanding safety in clinical use. The mechanism for the outstanding immune response induction are the prolonged production of antigen leading to continuous loading of germinal centers and the adjuvant effect of the LNPs, which selectively stimulate T follicular helper cells that drive germinal center responses. Vaccine against many pathogens, including HIV, HCV, HSV2, CMV, universal influenza, coronavirus variants, pancoronavirus, nipah, norovirus, malaria, TB, and many others are currently in development. Nucleoside-modified mRNA is also being developed for therapeutic protein delivery. Clinical trials with mRNA encoded monoclonal antibodies are underway and many other therapeutic or genetic deficient proteins are being developed. Finally, nucleoside-modified mRNA-LNPs are being developed and used for gene therapy. Cas9 knockout to treat transthyretin amyloidosis has shown success in phase 1 trials. We have developed the ability to target specific cells and organs, including lung, brain, heart, CD4+ cells, all T cells, and bone marrow stem cells, with LNPs allowing specific delivery of gene editing and insertion systems to treat diseases such as sickle cell anemia, Nucleoside-modified mRNA will have an enormous potential in the development of new medical therapies.
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RNA Innovation Seminar Series | |
Upcoming Affiliated Seminars | | |
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HMS Initiative for RNA Medicine Seminar Series
"Applications of RNA Activation in Medicine"
Brid Ryan, PhD, MPH, SVP research, MiNA Therapeutics, Translational & Innovation Hub
Tuesday, January 30th, 2023 | 3:00 – 4:00 PM EST
To Join Virtually Click This Link
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Department of Cell & Developmental Biology Seminar Series | |
Department of Neurology Grand Rounds | | |
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For more information and to view the full schedule of upcoming U-M Oral Defenses, please visit the Rackham Graduate School Oral Defenses website. | |
From our sponsor: Lexogen RNA Expertise Blog Series | |
Yan Zhang's Lab Article in Molecular Cell | |
John Prensner Publishes Findings on New Treatment for Medulloblastoma | |
Scientist Will Test a Cancer-Hunting mRNA Treatment | | |
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Stran Therapeutics has figured out a way to turn the molecule on and off in certain tissues to more precisely treat tumors.
Read the full story in WIRED by Emily Mullin, January 22, 2024.
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Nils Walter & Adrien Chauvier publish new review article - and it's about time... literally! | | |
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Center for RNA Biomedicine Co-Director Nils Walter, Ph.D. is excited about sharing some news about yet another fascinating role RNA plays in gene regulation – and it’s about time… literally.
In a new review article, “Regulation of bacterial gene expression by non-coding RNA: It is all about time!” published January 10, 2024, in the journal Cell Chemical Biology, Walter and his colleague Adrien Chauvier, Ph.D., at the Single Molecule Analysis Group and Center for RNA Biomedicine, Department of Chemistry, University of Michigan, discuss the vital role that speed plays in the process of non-coding RNA (ncRNA) folding in bacteria.
Read the full review article: Science Direct
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Dr. Rao's Michigan Answer: Finding New Hope for People with Vision Loss | | |
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"Unmasking the Power of RNA: From Structure to Medicine"
The 8th annual symposium will take place on Friday, March 8, 8:30 a.m. - 5:00 p.m. in the A. Alfred Taubman Biomedical Science Research Bldg., Kahn Auditorium at 109 Zina Pitcher Place in Ann Arbor, Michigan. Speakers include:
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Drew Weissman, M.D., Ph.D., University of Pennsylvania, 2023 Nobel laureate for Physiology or Medicine for his work on mRNA vaccines
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Victoria D'Souza, Ph.D., Harvard University
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Brenton R. Graveley, Ph.D., University of Connecticut
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Leemor Joshua-Tor, Ph.D., Cold Spring Harbor Laboratory
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Peter Todd, M.D., Ph.D., University of Michigan
Download the 2024 RNA Symposium Flyer
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HIRM 2024 Symposium, April 25, 2024 | | |
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2024 Symposium
HIRM 10 Year Anniversary Symposium
Thursday, April 25, 2024
Joseph B. Martin Conference Center
77 Avenue Louis Pasteur
Boston, MA 02115
Registration & Poster Session Applications will open in January 2024.
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RNA Society Annual Meeting May 28 - June 2, 2024 | |
Exciting News! RiboClub 25th / RiboWest 20th / TREnD 8th Anniversary Celebration in Ottawa: RNA Canada 2024: The future of RNA technology | | |
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Our members' publications are available through Altmetric. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation.
Below are recent highlights. Bold denotes CRB member.
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Hatfield BM, Weidmann CA, Weeks KM. Measuring Proximity-Mediated Function of mRNA Regulatory Proteins by Engineered Tethering. Methods Mol Biol. 2024;2723:143-159. doi: 10.1007/978-1-0716-3481-3_9. PMID: 37824069; PMCID: PMC10621603. https://doi.org/10.1007/978-1-0716-3481-3_9 | |
Goutman SA, Boss J, Jang DG, Mukherjee B, Richardson RJ, Batterman S, Feldman EL. Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort. J Neurol Neurosurg Psychiatry. 2023 Sep 27:jnnp-2023-332121. doi: 10.1136/jnnp-2023-332121. Epub ahead of print. PMID: 37758454. https://doi.org/10.1136/jnnp-2023-332121 | |
Smith TJ, Giles RN, Koutmou KS. Anticodon stem-loop tRNA modifications influence codon decoding and frame maintenance during translation. Semin Cell Dev Biol. 2024 Feb 15;154(Pt B):105-113. doi: 10.1016/j.semcdb.2023.06.003. Epub 2023 Jun 28. PMID: 37385829. https://doi.org/10.1016/j.semcdb.2023.06.003 | |
Wilhelm CA, Mallik L, Kelly AL, Brotzman S, Mendoza J, Anders AG, Leskaj S, Castillo C, Ruotolo BT, Cianfrocco MA, Koutmos M. Bacterial RNA-free RNase P: structural and functional characterization of multiple oligomeric forms of a minimal protein-only ribonuclease P. J Biol Chem. 2023 Oct 6:105327. doi: 10.1016/j.jbc.2023.105327. Epub ahead of print. PMID: 37806495. https://doi.org/10.1016/j.jbc.2023.105327 | |
Hou Q, Chatterjee S, Lund PE, Suddala KC, Walter NG. Single-molecule FRET observes opposing effects of urea and TMAO on structurally similar meso- and thermophilic riboswitch RNAs. Nucleic Acids Res. 2023 Oct 19:gkad866. doi: 10.1093/nar/gkad866. Epub ahead of print. PMID: 37855661. https://doi.org/10.1093/nar/gkad866 | |
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Postdoctoral Research Fellow and Graduate Research Assistants
Dr. Guizhi (Julian) Zhu Lab | University of Michigan
Multiple full-time openings for Postdoctoral Research Fellow and Graduate Research Assistants. Learn more.
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Research Technician and Post-Doctoral Research Fellow | Fred Hutchinson Cancer Center | The Lapointe Lab
Seeking to fill two positions: Research Technician and Post-Doctoral Research Fellow. Learn more.
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Research Technician - Yadavalli Lab
Seeking full-time technician or research scientist to perform cutting-edge research in RNA biology using high-throughput sequencing methods. Learn more.
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Postdoctoral Position - Maquat Lab
A postdoctoral position is open. Applicants should hold a PhD or MD/PhD degree(s) and have expertise in molecular, cellular, or structural biology. Learn more.
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Postdoctoral Position - Cooperman Laboratory
Seeking postdoctoral student with a strong interest in understanding the mechanism and regulation of cytoplasmic eukaryotic protein synthesis. Learn more.
| | For complete details on current openings and how to apply for these positions, visit the Recruitment Opportunities page on our website | | | | |
