Is the damage beyond repair by tau?

Dear Researcher,

  

 Tau proteins, microtubule-associated proteins, are predominately found in the brain. Several diseases are associated with the accumulation of tau protein in neurons, including Alzheimer’s disease (AD). Western blot (WB) and immunofluorescence (IF) analyses remain popular techniques for detecting tau in the human CSF cohorts.


  Biosensis' tau antibodies are used in WB, ICC, and IHC applications (see here).   

Left image: IF analysis of cortical neuron and glial cultures from rat stained with Chicken pAb to tau

(C-1691; green)costained with MAP2 Ab (red), and nuclear DNA (blue)

Right images:

TopWB analysis of tissue lysates using Chicken pAb to tau (C-1691; green) and protein standard (red).

BottomE18 hippocampal neurons stained with Mouse mAb (M-1703; red) and Chicken pAb to alpha Internexin (green), and DNA (blue).

Antibodies for tau research

  Biosensis offers two tau antibodies: Chicken Polyclonal (C-1691) and Mouse Monoclonal (M-1703). These antibodies have been epitope mapped for distinct regions of the molecule and recognize the unphosphorylated forms of tau.  

Is the damage beyond repair by tau?

 In a recent paper published by Nature, Utsugi et al. (2022) used tau antibodies in IF and WB to show how both phosphorylated and unphosphorylated tau accumulates upon severe DNA double-strand breakage.

IF images using mouse antibodies against tau (green) of mice primary neuron.

WB analysis of tau in cytoplasm and nucleus from mice primary neuron lysates.

For easy online ordering, head to our new website, or contact our friendly sales team at sales@biosensis.com.


For more information about our products email biospeak@biosensis.com.


Best wishes for your research,



The Biosensis Team



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