January 8, 2024

NRG Oncology Broadcast archives are accessible from our website at any time. Please bookmark this link for your convenience.

The NRG Oncology 2024 Winter Meeting is Open for Registration!

The NRG Winter Meeting will be held in-person only at the World Center Marriott in Orlando, FL from Thursday, February 15, 2024 - Saturday, February 17, 2024 with select virtual session offerings. Please visit our meeting webpage for the agenda and more information. Register here

Winter Symposium - IDEA: Inclusion, Diversity, Equity and Access of Underrepresented Patients to Clinical Trials

Register here for the Winter 2024 Educational Symposium on Thursday, February 15, 2024 from 8am-12pm ET. The symposium will include noted Oncologists and Scientists serving as speakers and moderators. The speakers will focus their presentations on providing a framework for the barriers and solutions to increasing IDEA (Inclusion, Diversity, Equity, and Access) of underrepresented patients to clinical trials. Read more

NRG Oncology Protocol Support Committee – Educational Sessions

Please be sure to sign up to attend the PSC Nurse/CRP Sessions being held during the NRG Oncology Winter Meeting in Orlando. The Protocol Support Committee (PSC) will offer Introduction to Clinical Trials: Principles of NRG Oncology Clinical Trial Management for Nurse/CRPs on Thursday, February 15th; and Continuing Education Session for Nurse/CRPs on Friday, February 16th. These sessions will be held virtually and in-person and are for both seasoned and new research staff. Please refer to the posted flyers and agendas (login required) for more details about the PSC programing offered at #NRG2024.

The PSC is thrilled to announce that the PSC sessions have been approved by the Virginia Nurses Association to award contact hours. The Virginia Nurses Association is accredited as an approver of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.

#NRG2024 Social Media Workshop – Virtual Session

The NRG Oncology Communications Committee is pleased to announce our Social Media Workshop as part of #NRG2024. The workshop, held as a virtual session, is scheduled for Monday, February 12th from 4-5pm ET. Drs. Kristin Higgins and Miriam Knoll, members of the NRG Oncology Communications Committee, are the workshop chairs. The session speakers include Kristen Kimball, advocate for lung cancer awareness and retired physiology instructor from Boston; and Dr. Lucinda Morris, a radiation oncologist and co-chair of the Targeting Cancer initiative, from Sydney, Australia. Please see the session flyer for details. Register here.

ACTIVATIONS

HEAD & NECK

NRG-HN011: Activation Date: January 8, 2024 (posted on CTSU)

LUNG

NRG-LU004: Reopening to Accrual with Amendment 6; version date: October 16, 2023 (posted on CTSU). Study Memorandum dated January 5, 2024 and Forms (posted on NRG Oncology).

AMENDMENTS

BREAST

NRG-BR007/DEBRA: Amendment 1; version date: October 20, 2023 (posted on CTSU)

HEAD & NECK

NRG-HN008: Amendment 4; version date: December 14, 2023 (posted on CTSU). Study Memorandum dated January 8, 2024 (posted on NRG Oncology).

OTHER PROTOCOL NOTICES

1. ALL DISEASE SITES

NRG-GY022: Reminder: Actively Recruiting MALE Patients only Read More

2. BIOSPECIMEN BANK

Printing Biospecimen Transmittal PDFs from Rave

Please note an effort is underway to clarify how to obtain a Biospecimen Transmittal PDF for submission to the NRG Oncology Biospecimen Bank. Read More

3. BREAST

NRG-BR007/DEBRA: Updated Pathology Instructions, version date December 19, 2023 (posted on CTSU) 

4. CANCER PREVENTION & CONTROL

NRG-CC005/FORTE:

• FORTE Friday eNewsletter
• eBlast: NRG Oncology Winter Meeting information (posted on CTSU)
• Mailing Materials: Envelope and AveryPresta942RectangleLabels (posted on CTSU)

NRG-CC010: The study is now open to NRG sites in Japan and South Korea. The optional biospecimen collection does not apply to sites participating in these countries

5. GASTROINTESTINAL

NRG-GI008/CIRCULATE-North America: Memorandum, dated January 4, 2024, re: Important reminders for submitting blood and tissue specimens to Natera for central ctDNA testing (posted on CTSU)

6. GENITOURINARY

NRG-GU012: Reminder! This phase II trial for patients with metastatic unresected renal cell cancer is open to enrollment. The study is open to all NCTN member sites in the U.S and Canada. Please help us enroll. Protocol documents are posted on CTSU.

7. GYNECOLOGIC

GOG-0210: Reminder! Biospecimens, biomarker data, clinical data, and epidemiologic data are available for request. Please visit the NRG Oncology website for more information on this important study with the overall goal of improving the outcome and/or quality of life for patients with endometrial cancer.

NRG-GY031: Please note, there is an error in the section 4.2 table and the Biospecimen Collection and Submission Manual. The Part I PK collection is to be done on Cycle 1, Day 1, and Cycle 1, Day 8. This will be updated with the next amendment.

8. HEAD & NECK

NRG-HN008: Reminder! please update treatment and AE data weekly. This is a Phase I trial and timely data submission is very important. 

9. VTOC TRAINING

The VTOC Webinar Training Series schedule and registration is available for NRG Oncology Research Associates working on RTOG 0924, RTOG 0920, NRG-HN001, NRG-HN002, NRG-CC003, NRG-CC005, NRG-BR009, and NRG/SWOG S1914. Space is limited so register now and reserve your seat. The next webinar training is scheduled for Wednesday, January 17, 2024.

DRUG SAFETY AND INVESTIGATOR’S BROCHURE (IB) UPDATES

Drug Safety and Investigator’s Brochure updates have been issued for the following studies:

*The current version of the Investigator Brochure Documents for Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute (NCI)-sponsored trials are available for access via the Cancer Therapy Evaluation Program (CTEP) Agent Inventory Management System (AURORA) application. Log-in using your Identity and Access Management (IAM) or ID.me credentials and provide the requested information to access the document.

Every site principal investigator is responsible for reviewing this document. The Investigator Brochure is for use by the site principal investigator and any study personnel under his/her supervision who need to know the contents for the conduct of a clinical trial, including Institutional Review Board(s) or Independent Ethics Committee(s).

New Request for Early IRB Closure Form

CTSU’s Request for LPO Approval of Early Closure Form is now available on the CTSU website under Resources > CTSU Operations Information > CTSU Forms. This form will replace the NRG Early IRB Closure form. Additional NRG instructions are located on the NRG website. When a site wants to close a study locally prior to study-wide termination, they must complete and submit this form to NRG. If approved, they must then submit it to the NCICIRB via IRBManager or to the CTSU via the Regulatory Submission Portal, whichever is appropriate per the instructions. The CIRB and the CTSU will not process an early closure without documentation that the LPO has approved it. 

NRG Oncology Confidential Member Survey

Please read our survey FAQ’s. All NRG Members should have received an email from the University of Chicago’s Survey Lab containing a unique survey link. If you have not already completed the survey, please check your inbox and possibly your spam/junk mailbox for the email so that you can help us collect this important information. Please send any additional questions to nrg-broadcasts@nrgoncology.org.

MLK Day Holiday Closures

Please note the following NRG Oncology locations will be closed for the Martin Luther King, Jr. holiday on Monday, January 15, 2024. We will resume regular business hours on Tuesday, January 16, 2024.

• Philadelphia East Operations Center
• Philadelphia West Operations Center
• Pittsburgh Operations Center
• Buffalo SDMC office
• Philadelphia SDMC
• Pittsburgh SDMC
• Biospecimen Bank – San Francisco
• Biospecimen Bank – Pittsburgh
• Serum Bank- Baylor (no shipping restrictions)

 -The Biospecimen Bank in Columbus will be open during regular business hours on Monday, January 15, 2024.

 -McKesson’s Clinical Research Services: In observance of Martin Luther King, Jr. Day, McKesson’s Clinical Research Services will be closed Monday, January 15, 2024. If you have questions regarding the shipment schedule, please contact the Clinical Research Services team at 800.693.4906, or via e-mail at clinicalresearchservices@mckesson.com.

NRG Oncology is pleased to report the scientific articles that have appeared during the previous week as well as an abstract accepted for presentation at the upcoming Multidisciplinary Head and Neck Cancers Symposium (MHNCS) in February.

This publications report includes links, when available, to the article, PubMed abstract, or association abstract.

PUBLISHED ARTICLES

Tchelebi LT, Winter KA, Abrams RA, Safran HP, Regine WF, McNulty S, Wu A, Du KL, Seaward SA, Bian SX, Aljumaily R, Shivnani A, Knoble JL, Crocenzi TS, DiPetrillo TA, Roof KS, Crane CH, Goodman KA. Analysis of Radiation Therapy Quality Assurance in NRG Oncology RTOG 0848. Int J Radiat Oncol Biol Phys. 2024 Jan 1;118(1):107-114. doi: 10.1016/j.ijrobp.2023.08.014. Epub 2023 Aug 19. PMID: 37598723. Read More.

ACCEPTED ABSTRACTS

Gharzai L, Morris E, Nguyen-Tan P, Rosenthal DI, Gillison ML, Harari PM, Garden AS, Zanotti KM, Caudell JJ, Jones CU, Mitchell DL, Krempl G, Ridge JA, Gensheimer MF, Bonner JA, Le Q, Torres-Saavedra P, Schipper MJ, Mierzwa M. Surrogate endpoints in p16-positive squamous cell carcinoma of the oropharynx. MHNCS (Multidisciplinary Head and Neck Cancers Symposium). 2/29/2024. Poster Presentation.

Please note the following upcoming meeting and abstract submission deadline dates

UPCOMING MEETINGS

American Association for Thoracic Surgery (AATS); Apr 27-30, 2024; Toronto, ON

American College of Radiology (ACR); Apr 13-17, 2024; Washington, DC

American Head & Neck Society (AHNS); May 15-16, 2024; Chicago, IL

American Radium Society (ARS); May 2-5, 2024; Palm Springs, CA

American Society of Breast Surgeons (ABS); Apr 10-14, 2024; Orlando, FL

American Society of Clinical Oncology (ASCO) GI; Jan 18-20, 2024; San Francisco, CA

American Society of Clinical Oncology (ASCO) GU; Jan 25-27, 2024; San Francisco, CA

American Society of Colon and Rectal Surgeons (ASCRS); Jun 1-4, 2024; Baltimore, MD

Society for Clinical Trials (SCT); May 19-22, 2024; Boston, MA

Society of Gynecologic Oncology (SGO); Mar 16-18, 2024; San Diego, CA

Society of Surgical Oncology (SSO); Mar 20-23, 2024; Atlanta, GA

Society of Surgical Oncology (SSO) - Advanced Cancer Therapies (ACT); Feb 16-19, 2024; San Juan, Puerto Rico

UPCOMING ABSTRACT SUBMISSION DEADLINES

American Association for Cancer Research (AACR); Apr 5-10, 2024; San Diego, CA; LBA Jan 8, 2024, 11:59 pm ET

American Society of Clinical Oncology (ASCO); Chicago, IL; due to publications committee Jan 23, 2024; submission deadline Feb 6, 2024, 11:59 pm ET; LBA Mar 11, 2024, 11:59 pm ET (placeholder required)

American Society for Radiation Oncology (ASTRO); Sep 29-Oct 2, 2024; Washington, DC; due to publications committee Feb 27, 2024; submission deadline Mar 12, 2024; LBA Jul 12, 2024

EORTC-NCI-AACR Symposium on Molecular Targets and therapies; Oct 23-25, 2024; Barcelona, Spain; due to publications committee Jun 13, 2024; submission deadline Jun 27, 2024; LBA Sep 26, 2024

European Society of Gynaecological Oncology (ESGO); Mar 7-10, 2024; Barcelona, Spain; LBA Jan 15, 2024

European Society for Medical Oncology (ESMO); Sep 13-17, 2024; Barcelona, Spain; due to publications committee Apr 23, 2024; submission deadline May 7, 2024, 21:00 CET; LBA Aug 7, 2024, 21:00 CET (placeholder required)

European Society for Medical Oncology (ESMO) Breast Cancer; May 15-17, 2024; Berlin, Germany; due to publications committee Jan 30, 2024; submission deadline Feb 13, 2024, 21:00 CET; LBA Apr 17, 2024, 21:00 CET (placeholder required)

European Society for Medical Oncology (ESMO) Gastrointestinal; Jun 26-29, 2024; Munich, Germany; due to publications committee Jan 30, 2024; submission deadline Apr 9, 2024, 21:00 CET; LBA Jun 6, 2024, 21:00 CET (placeholder required)

European Society for Medical Oncology (ESMO) Gynaecological; Jun 20-22, 2024; Florence, Italy; due to publications committee Mar 20, 2024; submission deadline Apr 3, 2024, 21:00 CET (placeholder required)

European Society for Radiotherapy and Oncology (ESTRO); May 3-7, 2024; Glasgow, Scotland; LBA Jan 24, 2024