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The RNA Transcript, December 19, 2022

TODAY

U-M RNA Innovation Seminar

The Science Behind mRNA Medicines: COVID-19 Vaccines and Beyond

Melissa Moore, Moderna Therapeutics, Emerita


Dr. Moore will be awarded an honorary degree at the University of Michigan Ann Arbor campus’ 2022 Winter Commencement and give this scientific talk to our RNA community.


Reception to follow after seminar.


TODAY, December 19, 2022

12:00 - 1:00 p.m.

BSRB, Kahn Auditorium, Zoom

U-M RNA Innovation Seminar

Antisense oligonucleotides for Ataxia

Hayley McLoughlin, University of Michigan

Assistant Professor of Neurology & Human Genetics


TODAY, December 19, 2022

4:00 - 5:00 p.m.

BSRB, ABC Seminar Rooms, Zoom

POSTPONED Bay Area RNA Club Meeting

Out of respect of our valued trainees and staff on the strike line, the Bay Area RNA Meeting will be postponed until the new year. We are hopeful that a fair negotiation will happen soon, and look forward to a meeting where everyone can participate fully.


For over two decades the BARC has facilitated our ability to come together as a community. We are really looking forward to connecting with you and learning more about your exciting RNA science.


Hoping everyone has a safe and relaxing holidays. Once the strike is resolved, we will send an announcement with a new date in 2023.


Liana, Andy, Michael, Joshua, and Stephen

U-M RNA Innovation Seminar

Genetic Variant Effects on Adipose Gene Expression and Their Role in Cardiometabloic Traits.

Karen Mohlke, UNC, Chapel Hill

Professor of Genetics & Associate Chair for Research

Oliver Smithies Investigator


Monday, January 9, 2023

4:00 - 5:00 p.m.

BSRB, ABC Seminar Rooms, Zoom

RNA Collaborative Seminar Host: University of Michigan RNA Biomedicine

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Speaker: Rachel Niederer

Uncovering Novel Translational Control Elements within 5'-UTRs.


Speaker: Jay Querido

The Structural Basis of Translational Initiation and its Regulation by the RNA Helicase eIF4A


Moderator: Mats Ljungman


Wednesday, January 18, 2023.

Zoom.

7th Nucleic Acids Conference: 09-12 February 2023

In case you are interested in escaping the Michigan winter for a few days and want to help me boost the UM representation at the 7th Nucleic Acids conference. There are some speaker slots still open, and you can bring family and book extra nights.


News

Medical School Research Annual Report 2022

Congratulations to Sundeep Kalantry, Ph.D. Professor, Human Genetics & Marissa Cloutier, Ph.D. Student. For their research and story being published in the Medical School Research Annual Report 2022.


The Why of the Silent X, Sundeep Kalantry & Marissa Cloutier.

The Michigan Institute for Data Science (MIDAS) Fellowship Application

The Michigan Institute for Data Science (MIDAS) is seeking applications for a new AI in Science Postdoctoral Fellowship Program at the University of Michigan (the Schmidt AI in Science program). Funding for the program comes from the Eric & Wendy Schmidt Postdoctoral Fellowship, a program of Schmidt Futures. This program provides outstanding early-career researchers with intensive training & research experience as they ready themselves for independent research in academic & other sectors. We aim to enable the substantive us of AI for breakthroughs in science & engineering, & cultivate global science leaders. Specifically, we will:


1) Catalyze creative & transformative applications of AI with the potential to lead to major scientific breakthroughs carried out by the Fellows and their mentors.

2) Enable a broader U-M research community to adopt AI in imagining, planning, executing, & supporting research applications across a range of science & engineering domains.

3) Provide outstanding traing to the Fellows.

4) Collaborate with other sites to maximize the impact of the program.


Submit Application: here.

Our members' publications are available through Altmetrics. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation.


Below are recent highlights.

Watts, J. A., Grunseich, C., Rodriguez, Y., Liu, Y., Li, D., Burdick, J. T., Bruzel, A., Crouch, R. J., Mahley, R. W., Wilson, S. H., & Cheung, V. G. (2022). A common transcriptional mechanism involving R-loop and RNA abasic site regulates an enhancer RNA of APOE. Nucleic acids research, gkac1107. Advance online publication. https://doi.org/10.1093/nar/gkac1107 https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac1107/6858851?login=true

Liu, Y., Munsayac, A., Hall, I., & Keane, S. C. (2022). Solution Structure of NPSL2, A Regulatory Element in the oncomiR-1 RNA. Journal of molecular biology, 167688. Advance online publication. doi.org/10.1016/j.jmb.2022.167688

Riella, C. V., McNulty, M., Ribas, G. T., Tattersfield, C. F., Perez-Gill, C., Eichinger, F., Kelly, J., Chun, J., Subramanian, B., Guizelini, D., Nephrotic Syndrome Study Network (NEPTUNE), Alper, S. L., Pollak, M. R., Sampson, M. G., & Friedman, D. J. (2022). ADAR regulates APOL1 via A-to-I RNA editing by inhibition of MDA5 activation in a paradoxical biological circuit. Proceedings of the National Academy of Sciences of the United States of America, 119(44), e2210150119. https://doi.org/10.1073/pnas.2210150119

To share your news and comments, please contact rna-communications@umich.edu

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