M-1572-100: Analysis of 14-3-3 eta expression in HeLa cells by ICC using mouse antibody to 14-3-3 protein eta (red).

Blue: DAPI nuclear stain. The antibody reveals the diffuse cytoplasmic distribution of 14-3-3 protein with higher concentration in the perinuclear region. 

The 14-3-3 eta protein is abundant in the brain and, through binding, regulates the activity of various proteins in significant signaling-related protein families, such as kinases, phosphatases, and transcription factors, thereby impacting neural signaling, development, protection, and degeneration. More recently, it is also a biomarker for neurological disorders, including ALS and AD.

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Salivary inflammatory biomarkers are predictive of mild cognitive impairment and Alzheimer’s disease in a feasibility study

This article unveils stratifin (SFN) detection using our anti-14-3-3 sigma/SFN antibody

anti-14-3-3 sigma/SFN antibody (R-2115-100) via ELISA.

Flow Cytometry: Analysis of U20S cells SFN expression using anti-14-3-3 sigma/SFN antibody (R-2115-100) far left plot in blue.

Immunofluorescence: Analysis of 14-3-3 sigma/SFN using anti-14-3-3 sigma/SFN antibody in paraffin-embedded section of A431 cells (left), and A 549 cells (right), catalogue number R-2115-100.

Anti-14-3-3 sigma/stratifin (SFN) 

Using the anti-14-3-3 sigma/SFN antibody, researchers can analyze the presence, localization, and expression levels of 14-3-3 sigma protein in brain tissues or cells. This antibody enables investigations into protein-protein interactions, cellular signaling cascades, and potential therapeutic targets for neurological disorders, as well as being linked to the detection of a wide range of cancer cells.

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