The RNA Transcript, September 26, 2022

Please join us TODAY as we welcome our guest speaker David Shechner, University of Washington at 4 PM BSRB, ABC room. This is an *internal event* with zoom option for U-M researchers only.

U-M Oral Dissertation Defense

Mechanistic Evaluation of Early Phases of Drug Release From Polymer Microparticles Prepared by Atomization Techniques

Richard Schutzman, advisor: Steve Schwendeman

Wednesday, September 28, 2022

10:00 - 11:00 a.m.

NCRC Building B10-G063/G064

U-M DCMB 10th Anniversary Symposium and Celebration

Science Talks and the 8th Annual Gilbert S. Omenn Lecture

Data Science and Medicine in the Age of Open Data, Open Code, and Open Access: From Protein Structure Prediction to COVID Origins

Holden Thorp, Ph.D., Editor-in-Chief, Science 

Thursday, September 29, 2022

1:15 - 6:30 p.m.

event details and registration

NCCAT CryoEM Current Practices Webinar

Using Cryo-EM to Solve the Structures of Conformationally Dynamic RNAs 

Steve Bonilla, University of Colorado Anschutz Medical Campus

Thursday, September 29, 2022

12:00 - 1:00 p.m.

event details and registration

U-M Department of Chemistry Promotion Seminar

Incorporation and molecular level consequences of mRNA modifications

Kristin Koutmou, Seyhan N. Ege Assistant Professor of Chemistry

Thursday, September 29, 2022

4:00 - 5:00 p.m.

Chemistry room 1640

U-M Structure Seminar

Conformational Change of Methylenetetrahydrofolate Reductase in the Allosteric Regulation: Crystal Structure of Eukaryotic MTHFR in Complex with S-Adenosylmethionine

Kazuhiro Yamada, Markos Koutmos Lab

Friday, September 30, 2022

10:00 - 11:00 a.m.

LSI Library

U-M Precision Health Symposium

Present and future users of Michigan Genomics Initiative (MGI) data can meet fellow MGI researchers and learn about the breadth and scope of ongoing MGI-supported research.

Friday, September 30, 2022

11:00 a.m. - 5:00 p.m.

SPH I, room 1655

event details and registration

U-M Bioinnovations in Brain Cancer Symposium

U-M Oral Dissertation Defense

Development and Analytical Characterization of Lipid-Based Nanoparticles

Minzhi Yu, advisors: Anna Schwendeman and Steve Schwendeman

Monday, October 3, 2022

1:00 - 2:00 p.m.

NCRC Building 10-G065

RNA Collaborative Seminar, NUS-CSI Singapore RNA Biology Center

U-M Structure Seminar

Novel Structure of a Type I Polyketide Synthase Reductive Cassette

Tyler McCullough, Janet Smith Lab

Friday, October 7, 2022

10:00 - 11:00 a.m.

LSI Library

Roadblocks on mRNAs? Gene Expression Regulation by Upstream Open Reading Frames in Plants

Polly Hsu, Michigan State University

Monday, October 10, 2022

4:00 - 5:00 p.m.

BSRB, ABC with zoom option

Co-sponsored by Neurology, Human Genetics, and the Center for RNA Biomedicine

Monday, October 10, 2022

6:30 - 9:00 p.m.

Michigan Theatre

Ann Arbor, MI

U-M Structure Seminar

The "structural" journey of a ribonucleoprotein complex: From molecules to droplets

Rishav Mitra, James Bardwell Lab

Friday, October 14, 2022

10:00 - 11:00 a.m.

LSI Library

Job Opportunities

DNA/RNA/biologics at UMass Amherst

The Department of Chemistry at the University of Massachusetts Amherst, along with the Center for Bioactive Delivery within the Institute for Applied Life Sciences (IALS) invites applications for a full-time, tenure track faculty position. As the development of new therapeutic molecules shifts toward biologics, we seek applicants who will develop an innovative translational research program focused on therapeutic nucleic acids (RNA/DNA), proteins, or other functional biologics. Apply HERE by October 15, 2022.

Our members' publications are available through Altmetrics. Queries are currently available: CRISPR, microRNA, molecule, RNA, RNA therapeutics, transcriptome, and translation.

Below are recent highlights.

Magnuson, B., Bedi, K., Narayanan, I. V., Bartkowiak, B., Blinkiewicz, H., Paulsen, M. T., Greenleaf, A., & Ljungman, M. (2022). CDK12 regulates co-transcriptional splicing and RNA turnover in human cells. iScience, 25(9), 105030. doi.org/10.1016/j.isci.2022.105030

McLean, E. K., Nye, T. M., Lowder, F. C., & Simmons, L. A. (2022). The Impact of RNA-DNA Hybrids on Genome Integrity in Bacteria. Annual review of microbiology, 76, 461–480. doi.org/10.1146/annurev-micro-102521-014450

Pham, V. V., Gao, M., Meagher, J. L., Smith, J. L., & D'Souza, V. M. (2022). A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA. Communications biology, 5(1), 819. pubmed.ncbi.nlm.nih.gov/35970937

Liu, Y., Munsayac, A., Hall, I., & Keane, S. C. (2022). Solution Structure of NPSL2, A Regulatory Element in the oncomiR-1 RNA. Journal of molecular biology, 167688. Advance online publication. doi.org/10.1016/j.jmb.2022.167688