Protein-to-structure Pipeline for Ambient Temperature in situ Crystallography at VMXi | |
Image Source: Mikolajek et al. (2023). IUCrJ, 10, 420-429, https://doi.org/10.1107/S2052252523003810 | |
In a paper at IUCrJ, Halina Mikolajek et al. present the "current status of the fully automated ambient-temperature beamline VMXi at Diamond Light Source." In addition, "the capability of the pipeline is illustrated using a range of user case studies representing different challenges, and from high and lower symmetry space groups and varied crystal sizes. It is also demonstrated that very rapid structure determination from crystals in situ within crystallization plates is now routine with minimal user intervention." | |
Room Temperature Screening Products | | |
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In the above paper, the utility of X-ray crystal structures determined under (room) ambient-temperature conditions are discussed.
If you are considering or already are conducting research under (room) ambient-temperature conditions, we offer a range of supplies, tools and instruments that will support your research.
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New Product - High Contrast CryoEM Grid Storage Boxes | | |
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Now available, high contrast cryoEM grid storage boxes for holding your clipped or unclipped grids. These grid boxes are easily seen when in LN.
The core is made out of a biologically degradable and durable polymer which can easily be cleaned with ethanol. Has unique & enlarged grid chambers. Transparent lid is rotatable and helps protect grids from ice contamination. Available individually or as a convenient starter kit.
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ACA Video Library Contest | | |
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The ACA Video Library Contest is underway. The contest is designed to solicit video content from ACA members that will be used to enhance the ACA Video Library.
The ACA Video Library is a repository of educational materials concerning crystallography. The goal is to curate content relevant to all levels of interest in crystallography. The first 10 submissions before the October 31, 2023 deadline will be automatically eligible for a $100 (USD) prize.
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Don't Forget, We Are At The IUCr Meeting | | |
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Reminder we will be at the IUCr meeting in Melbourne. Our booth numbers are 33 and 34. (See IUCr Floorplan)
If you are attending the meeting please stop by and say hello. We are exhibiting and will have a range of innovations you can see in person. These include our Manual Plunge Cooler and Temperature Controlled Cryostat, SSRL Plate Kit, Crystallography Sample Support System, High Contrast Grid Storage Boxes and much more. We are also conducting a raffle of fun prizes.
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At MiTeGen, we sponsor numerous events, conferences, workshops and symposiums throughout the year. These events include fields such as structural biology, crystallography, cryo-EM, beamline research and more. We believe in supporting researchers and our industry. Listed below are two upcoming events you might find interesting. | |
The CCP4 Northern Structural Biology Meeting is October 26th to the 27th in Nottingham, UK. Designed for early career researchers, and students to come together and share their knowledge and ideas in the field of structural biology. We are sponsoring and exhibiting at this event. | |  |
The PSDI 31st Protein Structure Determination in Industry meeting is November 12th to the 14th in Cambridge, UK. Themes include synergy of structural and computational approaches, structural biology across modalities and more. Features workshops, talks, and more. We are sponsoring and exhibiting at this event. | | |
Events, Workshops and Conferences | | |
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If you are looking for more events visit our events page. It lists conferences, workshops, symposiums, user meetings and more.
Topics include structural biology, material science, crystallography, cryo-EM, beamline research and more.
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Industry Resources and News | |
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Here is a small selection of industry resources and news for your browsing.
- Paper at Acta Cryst E, Foreword to the special virtual issue on Modern approaches and tools for teaching crystallography - Learn More
- CrystalNets vs TopCryst: A competition with a selection of 100 MOFs. See which tool performed better - Learn More
- CCDC Cambridge is now offering the CSD Landscape Generator as a standalone product. It can be used to inspire ideas about interactions you may expect to see in an unknown structure - Learn More
- Paper at Journal of Chemical Information and Modeling, Best Practices of Using AI-Based Models in Crystallography and Their Impact in Structural Biology - Learn More
- Paper at Acta Cryst D, LifeSoaks: a tool for analyzing solvent channels in protein crystals and obstacles for soaking experiments - Learn More
- Paper at Acta Cryst A, Crystal search – feasibility study of a real-time deep learning process for crystallization well images - Learn More
- Paper at Nature, Revealing protonation states and tracking substrate in serine hydroxymethyltransferase with room-temperature X-ray and neutron crystallography - Learn More
- Free online course offered by CCDC Cambridge will take you through the CSD Python API to carry out in-depth searching and chemical analyses of the chemistry data in the Cambridge Structural Database - Learn More
- Paper at Acta Cryst D, A standard descriptor for fixed-target serial crystallography - Learn More
- Listen to the DataVerse Podcast in which Tom Burnley speaks about his work with cryo-EM and how computational science can be used to help fight diseases such as Alzheimer's and diabetes - Learn More
- In the latest edition of ThermoFisher Scientifics Cryo-Talk, Dr. Peter Shen from University of Utah School of Medicine talks about cryo-EM, and merit badges for National Cryo-EM Centers - Learn More
- From Biophysical Journal, a new computational tool for rapid and accurate cryo-EM data refinement of membrane protein structures, using density-guided molecular dynamics simulations in diverse conditions - Learn More
- From bioRxiv, read about how Smart Leginon enables cryoEM screening automation across multiple grids - Learn More
- Watch video Smart Leginon Tutorial from SEMC - Learn More
- Paper at IUCrJ, MRC2020: improvements to Ximdisp and the MRC image-processing programs - Learn More
- From Cornell High Energy Synchrotron Source, see a picture from the 1966 construction on the CESR tunnel which began with a machine intended to dig subway tunnels - Learn More
- Read about the upgrades in process at Advanced Photon Source - Learn More
- Paper at Acta Cryst D, Raynals, an online tool for the analysis of dynamic light scattering - Learn More
- Paper at Acta Cryst A, Machine learning for classifying narrow-beam electron diffraction data - Learn More
- Find beamline proposal deadlines from around the world at Lightsources.org - Learn More
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A reminder that Our New Lab Program is available for those planning a new lab or are expanding their lab. It offers special discounts, startup bundles, and expert support and service. If you are starting or expanding your lab contact us and we'll explain the program in detail. Or if you know someone who is starting or expanding their lab please share this information with them. | |
Have your lab be the first to know. Follow us on social media! | | | | |
