CNPase: Myelin and Beyond

M-1802-100

Rat cerebellum stained with mouse anti-CNP (green, M-1802-100) and chicken anti-NF-M

(red, C-1393-50) by immunohistochemistry.

Blue: DAPI nuclear stain.

The CNP antibody specifically stains oligodendrocyte while NF-M antibody stains axons of neuronal cells.

R-1803-100

Mixed neuron-glial cell cultures stained with rabbit anti-CNP antibody (green, M-1803-100) and mouse anti-GFAP (red, M-1375-100) by immunocytochemistry. Blue is DNA staining.

The CNP antibody specifically stains oligodendrocytes in this part of the CNS, while the GFAP antibody stains astroglia.

C-1804-50

Rat cerebellum section stained with chicken anti-CNP (green,

C-1804-50) and rabbit anti-NF-H antibody (red, C-1393-50) by immunohistochemistry. The anti-CNP antibody detects oligodendrocytes along the axons of neurons visualized by the NF-H antibody.

Cyclic nucleotide phosphodiesterase (CNPase) plays a crucial role in myelin synthesis and degradation, neuronal health and regulating signaling molecules in the nervous system. Beyond myelin-producing cells, CNPase functions extend to non-myelinating cell membranes across various organs such as spleen, liver, heart and skeletal muscles. Some of its common applications are depicted in Figure 1.

Figure 1: Utilizations of CNPase as a Biomarker

Discover more about our CNPase antibodies today to enable effective labeling, visualization, and quantification within tissues or cultures

Biosensis is a company that is passionate about Science